A5084279372- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Receptor Mechanisms and Signaling
- Respiratory and Cough-Related Research
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Pediatric health and respiratory diseases
- Neuroscience of respiration and sleep
- Pharmaceutical studies and practices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Cystic Fibrosis Research Advances
- T-cell and B-cell Immunology
- Pharmacological Effects and Assays
- Child and Adolescent Health
- Pineapple and bromelain studies
- Protein Kinase Regulation and GTPase Signaling
- Food Allergy and Anaphylaxis Research
- Ion Channels and Receptors
- Delphi Technique in Research
- Biochemical Analysis and Sensing Techniques
Connecticut Children's Medical Center
2012-2024
University of Connecticut
1999-2019
UConn Health
2007-2018
Universität Hamburg
2013
University Medical Center Hamburg-Eppendorf
2013
Hartford Financial Services (United States)
2010
GTx (United States)
2009
Johannes Gutenberg University Mainz
2005
Boehringer Ingelheim (United States)
2000
University of Massachusetts Chan Medical School
2000
Childhood obesity contributes to a wide array of medical conditions, including asthma. There is also increasing evidence in adult patients admitted the intensive care unit (ICU) that increased morbidity and prolonged length stay. We hypothesized associated with need for duration therapy children ICU status asthmaticus.Retrospective cohort study.A tertiary pediatric university-affiliated children's hospital.We retrospectively examined data from all older than 2 yrs asthmaticus between April...
Abstract Mice sensitized to OVA and subjected acute aerosol exposures develop allergic airway disease (AAD). However, chronic continuous Ag exposure results in resolution of AAD the development local inhalational tolerance (LIT). Because we have previously observed persistence B cells bronchoalveolar lavage (BAL) hilar lymph nodes (HLN) at stage this model, investigated role modulation AAD. Although cell-deficient mice developed LIT, adoptive transfer HLN from LIT OVA-sensitized recipients...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Abstract Parental phenotype is known to influence the inheritance of atopic diseases, such as allergic asthma, with a maternal history being more significant risk factor for progeny than paternal history. We hypothesized that recall Th1- or Th2-type immune responses during pregnancy would result in transfer factors differentially impact development responsiveness offspring. Following weaning, susceptibility and severity airway disease (a murine model human asthma) was evaluated progeny,...
OBJECTIVE. The purpose of this work was to determine whether oral prednisolone is effective in weaning infants with bronchopulmonary dysplasia, after 36 weeks' postmenstrual age, off supplemental oxygen and identify factors associated successful weaning. METHODS. Data were abstracted from a standardized prospectively collected database at the John Dempsey Hospital NICU. Logistic regression receiver operating curve analyses used. RESULTS. Of 385 infants, 131 (34%) received 254 (66%) did not....
Background: Allergic asthma is a major cause of worldwide morbidity and results from inadequate immune regulation in response to innocuous, environmental antigens. The need exists understand the mechanisms that promote nonreactivity human-relevant allergens such as house dust mite (HDM) order develop curative therapies for asthma. aim our study was compare effects short-, intermediate- long-term HDM administration murine model determine ability exposure suppress allergic inflammation....
Wolfram syndrome is a rare autosomal recessive disorder affecting approximately 1 in 500,000 individuals. The most commonly caused by mutations the
Bromelain, a widely used pineapple extract with cysteine protease activity, has been shown to have immunomodulatory effects in variety of immune system models. The purpose the present study was determine orally administered bromelain an ovalbumin (OVA)‐induced murine model acute allergic airway disease (AAD). To establish AAD, female C57BL/6J mice were sensitized intraperitoneal (i.p.) OVA/alum and then challenged OVA aerosols for 3 days. Mice gavaged either (phosphate buffered saline)PBS or...
Status asthmaticus is a common cause of admission to pediatric intensive care unit (PICU). Children unresponsive medical therapies may require endotracheal intubation; however, this treatment carries significant risk, and thresholds for intubation vary. Our hypothesis was that children who sought at community hospitals received less aggressive more frequent than children's hospital.Retrospective cohort study.A university-affiliated hospital PICU.We retrospectively examined data from all...
Mice sensitized to ovalbumin develop allergic airway disease (AAD) with short-term aerosol challenge; however, inflammation resolves long-term challenge, referred as local inhalational tolerance (LIT).We sought determine if resolution of correlated increases in lymphocyte subsets lung compartments, including putative regulatory T cells.At the AAD stage, total numbers and B lymphocytes bronchoalveolar lavage (BAL) were significantly increased above controls; at LIT, reduced compared AAD. In...
Children are frequently admitted to hospitals for treatment of severe asthma exacerbations. Anecdotally, a cohort these children thought have multiple readmissions the intensive care unit (ICU), yet this group has not been characterized. The purpose study was examine factors related recurrent ICU admissions in with asthma.The authors conducted retrospective all pediatric between April 1997 and December 2007. more than one admission were defined as having near-fatal exacerbations.During...
Background. Asthma exacerbations are one of the most common causes hospitalization in children and account for approximately 10,000 intensive care unit (ICU) admissions per year United States. Despite prevalence this disease children, factors associated with development these severe largely unknown. Methods. A retrospective case–control study was conducted involving all eligible admitted to hospital asthma a 1-year period. Potential outcomes ICU exacerbation (cases) were compared those acute...
Corticosteroids enhance β-adrenergic responses by actions at both β-adrenoceptor (β-AR) and post-β-AR sites. The present study investigated the effects of dexamethasone on β-AR density, high-affinity β-agonist binding, G s α i protein expression, cAMP in bovine tracheal smooth muscle (bTSM). Dexamethasone treatment cultured bTSM cells increased total density 1.6- to 1.9-fold as assessed saturation binding [ 3 H]CGP-12177 displacement radioligand with isoproterenol. Isoproterenol bound two...