A5101822396- Nanoparticle-Based Drug Delivery
- Estrogen and related hormone effects
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Proteoglycans and glycosaminoglycans research
- Chemotherapy-induced cardiotoxicity and mitigation
China Pharmaceutical University
2019-2023
State Key Laboratory of Natural Medicine
2019
Programmable drug delivery systems hold great promise to enhance cancer treatment. Herein, a programmable system using chondroitin sulfate (CS)-based composite nanoparticle was developed for enhancing and sensitizing chemotherapy drug-resistant cancer. The composed of cross-linked CS hydrogel shell hydrophobic cores containing both free drugs CS-linked prodrugs. Interestingly, the could mediate tumor-specific CD44 targeting. After specific cellular uptake, payloads were suddenly released...
<p>PDF file - 206K, Supporting information includes fluorescence images of Bel-7402, MDA-MB-231 and MCF-7 cells after incubation with 2DG-SUC-ADM or free ADM at different time points, dynamics tumor-targeting ability 2DG-ICG-Der-01 in nude mice</p>