A5036496045- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Fluorine in Organic Chemistry
- Organic and Inorganic Chemical Reactions
- Inorganic Fluorides and Related Compounds
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Crystallography and molecular interactions
- Journalism and Media Studies
- Synthesis and Reactions of Organic Compounds
- Neuroscience of respiration and sleep
- Synthesis and Catalytic Reactions
- Diet, Metabolism, and Disease
- Radical Photochemical Reactions
- Organic Chemistry Cycloaddition Reactions
- Synthesis of β-Lactam Compounds
- Chemical Reactions and Isotopes
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Carbon dioxide utilization in catalysis
- Cannabis and Cannabinoid Research
Czech Academy of Sciences, Institute of Experimental Botany
2022
Palacký University Olomouc
2020-2022
St Petersburg University
2014-2019
ITMO University
2018
Lomonosov Moscow State University
2016
CF<sub>3</sub>-enones react with arenes in TfOH to give<italic>trans</italic>-1,3-diaryl-1-CF<sub>3</sub>indanes.
Reaction of 4-aryl-1,1,1-trifluorobut-3-en-2-ols [CF3-allyl alcohols, ArCH═CHCH(OH)CF3] with arenes under activation anhydrous FeCl3 or FSO3H was studied. We found that the transformation led to trifluoromethylated alkenes [Ar(Ar')CHCH═CHCF3] 1-trifluoromethylated indanes (CF3-indanes). The formation these two types reaction products strongly depends on nucleophilicity starting arene and electrophilicity cationic intermediates generated from CF3-allyl alcohols conditions. Benzene, anisole,...
Heteroaryl sulfonamides are important structural motifs in the medicinal and agrochemical industries. However, their synthesis often relies on use of heteroaryl sulfonyl chlorides, which unstable toxic reagents. Herein, we report a protocol that allows direct oxidative coupling thiols primary amines, readily available inexpensive commodity chemicals. The transformation proceeds under mild reaction conditions yields desired N-alkylated good yields. N-alkyl can be further transformed using...
The reactions of 3‐bromo‐ and 3,4‐dibromo‐CF 3 ‐enones with superacids were studied. Protonation these CF FSO H resulted in the formation cationic species that subsequently cyclized at –60 °C to give corresponding mono‐ dibromoindenols up 98 % yield. indenol products room temperature triflic acid (CF SO H) provided highly electrophilic trifluoromethylated indenyl cations. Subsequent reaction various arenes gave access 1‐CF ‐substituted indenes 84 yields. DFT calculations carried out obtain...
Reactions of (di-)bromo-substituted CF<sub>3</sub>-allyl alcohols with/without arenes with TfOH lead to CF<sub>3</sub>-alkenes or CF<sub>3</sub>-indenes.
2,4-Diaryl-1,1,1-trifluorobut-3-en-2-oles and their TMS-ethers in H<sub>2</sub>SO<sub>4</sub> at room temperature just 2 min are quantitatively cyclized into 1-aryl-3-trifluoromethyl-1<italic>H</italic>-indenes.
3-Aryl-2H-azirines react with acylketenes, generated by thermolysis of 5-arylfuran-2,3-diones, to give bridged 5,7-dioxa-1-azabicyclo[4.4.1]undeca-3,8-diene-2,10-diones and/or ortho-fused 6,6a,12,12a-tetrahydrobis[1,3]oxazino[3,2-a:3',2'-d]pyrazine-4,10-diones. The latter compounds, a new heterocyclic skeleton, are the result coupling two molecules azirine and acylketene can be prepared only from 3-aryl-2H-azirines having no electron-withdrawing groups in aryl substituent. Calculations at...
Photoactivated metal free deuteration of a double bond was developed in an environmentally friendly manner.
The reaction of trifluoroacetyl alkynes [ArC≡C(C=O)CF 3 ] with H 2 SO 4 or TfOH affords products addition the acids to acetylene bond. Hydrolysis these adducts results in formation corresponding 1,3‐diketones existing form enols [Ar(HO)C=CH(C=O)CF up 98 % yield. application less acidic TfOH‐pyridine system permits transformation into vinyl triflates 76 Moreover, this is totally stereoselective give only Z‐configured triflates. arenes under action HUSY zeolites CBV‐720 gives rise...
Abstract In the presence of FeCl 3 trifluoromethylated allyl alcohols undergo an electrophilic dimerization to indane derivatives.
Abstract gem‐Dichlorocyclopropane (I) reacts with benzene or electron rich methylbenzenes in the presence of superacidic TfOH to afford ring‐opened 3‐arylpent‐1‐enes.
Abstract Depending on the nucleophilicity of arene and electrophilicity cationic intermediates, title reaction leads either to aryl alkenes or indanes.