A5043759443- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Pharmacology and Obesity Treatment
- Sexual function and dysfunction studies
- Renal and related cancers
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Muscle metabolism and nutrition
- Testicular diseases and treatments
- Urinary Bladder and Prostate Research
- Cancer Immunotherapy and Biomarkers
- Biosensors and Analytical Detection
- Molecular Biology Techniques and Applications
- Cancer Diagnosis and Treatment
- Genital Health and Disease
- Tannin, Tannase and Anticancer Activities
- Urologic and reproductive health conditions
- Advanced biosensing and bioanalysis techniques
- Metastasis and carcinoma case studies
Japanese Red Cross Kanazawa Hospital
2017-2024
Kanazawa University
2010-2023
Osaka University
2023
Nippon Medical School Hospital
2023
Kanazawa University Hospital
2015
Iwate Medical University
2007
Emory University
2004-2006
Winship Cancer Institute
2005
Abstract One of the most critical issues in prostate cancer clinic is emerging hormone-refractory cancers (HRPCs) and their management. Prostate usually androgen dependent responds well to ablation therapy. However, at a certain stage, they eventually acquire androgen-independent more aggressive phenotype show poor response any anticancer therapies. To characterize molecular features clinical HRPCs, we analyzed gene expression profiles 25 HRPCs 10 hormone-sensitive (HSPCs) by genome-wide...
Purpose. We performed a randomised controlled study regarding the effects of androgen replacement therapy (ART) on lower urinary tract symptoms (LUTS) in hypogonadal men with benign prostate hypertrophy (BPH).
Abstract Osteocalcin and bone sialoprotein are the most abundant noncollagenous matrix proteins expressed by osteoblasts. Surprisingly, osteocalcin also malignant but not normal prostate epithelial cells. The purpose of this study is to investigate how expression regulated in cancer Our investigation revealed that (a) human promoter activities an androgen-independent cell line LNCaP lineage, C4-2B, were markedly enhanced 7- 12-fold a concentration-dependent manner conditioned medium...
Abstract The ADAM (a disintegrin and metalloprotease) family is a group of transmembrane proteins containing cell adhesive proteolytic functional domains. Microarray analysis detected elevated ADAM9 during the transition human LNCaP prostate cancer cells from an androgen-dependent to androgen-independent metastatic state. Using tissue array (N = 200), levels protein expression were also in malignant as compared with benign tissues. was found 43% glands light staining 87% increasing intensity...
Abstract BACKGROUND: The authors elucidated an etiologic role of human papillomavirus (HPV) infection in carcinoma the bladder. METHODS: One hundred seventeen 224 patients with bladder who were treated between 1997 and 2009 enrolled this study. presence HPV DNA was tested on frozen tissues that obtained by transurethral resection using a polymerases chain reaction‐based method. Localization observed archival tissue specimens situ hybridization (ISH) for high‐risk DNA. Cyclin‐dependent kinase...
Abstract BACKGROUND Prostate‐specific antigen (PSA) is a useful biomarker for risk classification in patients with prostate cancer. However, it unclear whether correlation exists between low PSA levels (<10 ng/ml) at diagnosis and prognosis. METHODS Of the 642 Japanese who underwent biopsy were diagnosed cancer Kanazawa University Hospital from 2000 to 2010, 406 level <20 ng/ml retrospectively reviewed. RESULTS 275 (68%) <10 ng/ml. Although percentage of Gleason score 8–10 <3.5...
Abstract BACKGROUND Tranilast is a therapeutic agent used in treatment of allergic diseases, although it has been reported to show anti‐tumor effects on some cancer cells. To elucidate the tranilast prostate cancer, we investigated mechanisms its effect cancer. METHODS The and related were both vitro cell lines bone‐derived stromal cells, vivo severe combined immunodeficient (SCID) mice. We verified clinical patients with advanced hormone refractory (HRPC). RESULTS inhibited proliferation...
Patients with high Gleason score, elevated prostate specific antigen (PSA) level, and advanced clinical stage are at increased risk for both local systemic relapse. Recent data suggests higher radiation doses decrease recurrence may ultimately benefit biochemical, metastasis-free disease-specific survival. No randomized is available on the benefits of long-term hormonal therapy (HT) in these patients. A prospective study efficacy safety trimodality treatment consisting HT, external beam...
BACKGROUND The matricellular protein secreted acidic and rich in cysteine (SPARC) plays an important role on tumor metastasis progression several cancers. However, the roles of SPARC prostate cancer (PCa) remain unclear. METHODS To identify tissue, immunohistochemical analysis was conducted using human tissue microarray. detect expression (LNCaP, DU145, PC-3) stromal cells, RT-PCR, western blot analysis, ELISA conducted. reveal function exogenous PCa AKT phosphorylation confirmed by after...
Androgen replacement therapy (ART) efficacy on late-onset hypogonadism (LOH) has been widely investigated in Western countries; however, it remains controversial whether ART can improve health and prolong active lifestyles. We prospectively assessed long-term effects the physical mental statuses of aging men with LOH Japan. The primary endpoint was health-related quality life by questionnaires. Secondary endpoints included glycemic control, lipid parameters, blood pressure, waist...
To measure changes in penile length (PL) over time before and after radical prostatectomy (RP), to investigate the underlying mechanisms for these changes.The stretched PL (SPL) of 102 patients was measured before, 10 days after, at 1, 3, 6, 9, 12, 18 24 months RP. The perpendicular distance from distal end membranous urethra midline pelvic outlet on mid-sagittal magnetic resonance imaging (MRI) slice three points: preoperatively; RP; 12 Pre- postoperative SPLs were compared using paired...
Cytosine deaminase (CD) activates prodrug 5-FC to 5-FU and is used for suicide gene therapy (the CD/5-FC system). E. coli uracil phosphoribosyltransferase (UPRT) a pyrimidine salvage enzyme that directly converts into 5-fluorouridine monophosphate improves the antitumoral effect of 5-FU. This study demonstrates effectiveness transduction UPRT in addition cancer therapy.We investigated combined human hormone independent prostate cell line DU145 using two separate adenovirus vectors expressing...
To evaluate the biomarkers of sexual function, we investigated relationship between questionnaire responses and biological hormones such as testosterone (T) cortisol (F) in serum saliva. The study population included 105 men aged 30–72 years (mean: 49±4.5, median: 49). Levels all (Total-T, Free-T, Bioavailable-T, Total-F Bioavailable-F) salivary (Saliva-T Saliva-F) were measured directly by liquid chromatography/tandem mass spectrometry. International Index Erectile Function (IIEF) was used...
Objective: The present subanalysis of the EARTH study investigates effects one year testosterone replacement therapy (TRT) on sleep disturbance among hypogonadal men without obstructive apnea.Methods: Sleep was defined as three or more points in question 4 aging males symptoms (AMS) questionnaire. All participants completed AMS scale, International Prostatic Symptoms Score (IPSS), Sexual Health Inventory for Men (SHIM) and Short Form 36 (SF-36) health survey at baseline after 12 months. were...
Objective: We investigated the effects of testosterone replacement therapy (TRT) on bone mineral density (BMD) among hypogonadal men with osteopenia/osteoporosis.Methods: From our previous EARTH study population, 74 patients a clinical diagnosis osteopenia or osteoporosis and hypogonadism were included in this study, as TRT (n = 35) control 34) groups. The group was administered 250 mg enanthate injection every 4 weeks for 12 months. BMD, waist circumference, body mass index, fat percentage,...
Abstract The status of human papillomavirus (HPV) infection in urothelial inverted papilloma was examined the present study. Formalin‐fixed and paraffin‐embedded tissues from eight cases bladder were studied. presence HPV‐DNA by modified GP5/6+PCR using archival tissue sections microdissection. HPV genotype determined with a Hybri‐Max genotyping kit. Immunohistochemical analysis for p16‐INK4a, mcm7, HPV‐E4, L1, situ hybridization genome performed. detected seven (87.5%) papilloma. Three...
Study Type – Prognosis (case series) Level of Evidence 4 What’s known on the subject? and What does study add? Bone turnover markers such as BAP 1CTP in patients with SRE or metastatic bone progression were significantly higher at a later phase after starting treatment zoledronic acid compared those without progression. However, there are no evident biomarkers predicting survival an early treatment. The increase serum levels predicts short SRE‐free overall survival. measurement may be useful...
We investigated the effects of testosterone replacement therapy (TRT) on nocturia and general health among men with hypogonadism nocturia.From our previous EARTH study population, 64 patients a clinical diagnosis (two or more times per one night) hypogonadism, comprising TRT group (n = 31) controls 33), were included in this analysis. The was administered 250 mg enanthate as an intramuscular injection every 4 weeks for 6 months. All responded to following questionnaires: International...