A5103199661- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- Hormonal and reproductive studies
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Genital Health and Disease
- Pharmacology and Obesity Treatment
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Renal and related cancers
- Bone health and treatments
- Infectious Disease Case Reports and Treatments
- Cancer Immunotherapy and Biomarkers
- Sexual function and dysfunction studies
- Metastasis and carcinoma case studies
- Multiple and Secondary Primary Cancers
- Testicular diseases and treatments
- Cancer Diagnosis and Treatment
- Ureteral procedures and complications
- Health Promotion and Cardiovascular Prevention
- RNA Interference and Gene Delivery
Komatsu (Japan)
2017-2024
Secretaria de Planejamento e Gestão
2018
Kanazawa University
2005-2017
Kanazawa University Hospital
2017
Ishikawa Prefectural Central Hospital
2006
BioChem Technology (United States)
1998
Diminished expression of Raf kinase inhibitor protein (RKIP), an the signaling cascade, promotes prostate cancer (PCa) metastasis in a murine model, suggesting that it is suppressor gene. However, prognostic significance RKIP and its association with PCa patients unknown.To investigate marker we performed immunohistochemical staining for tissue microarrays consisting 758 non-neoplastic tissues, primary tumors metastases from 134 patients. The Cox proportional-hazards model was used to adjust...
Abstract Human prostate cancer has a high predisposition to metastasize bone, resulting in the formation of osteoblastic metastases. The mechanism through which cells promote lesions is undefined. Vascular endothelial growth factor (VEGF) been implicated as mediator osteoblast activity. In present study, we examined if activity VEGF. We found that LNCaP and C4-2B cell lines primary tumor metastatic tissues from patients expressed Bone morphogenetic proteins (BMPs), are normally bone...
Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of human and critical determinant the enzymatic activity telomerase. Expression hTERT known to be regulated mainly at transcriptional level. In present study, using transient expression assays, we identified 400 bp silencer promoter between -776 -378 upstream proximal core promoter. The inhibitory effects this were enhanced with cellular differentiation. A computer-assisted homology search multiple binding motifs for...
Abstract Background Oropharyngeal squamous cell carcinoma (OSCC) has shown a gradual increase in male predominance due to the increasing incidence of human papillomavirus (HPV)-associated OSCC. However, mode HPV transmission oral cavity is poorly understood, and little known about epidemiology infection men. The prevalence rates HPV, Neisseria gonorrhoeae , Chlamydia trachomatis Mycoplasma spp., Ureaplasma spp. were compared oropharynx (oral cavity) urine Japanese patients attending sexually...
BACKGROUND The matricellular protein secreted acidic and rich in cysteine (SPARC) plays an important role on tumor metastasis progression several cancers. However, the roles of SPARC prostate cancer (PCa) remain unclear. METHODS To identify tissue, immunohistochemical analysis was conducted using human tissue microarray. detect expression (LNCaP, DU145, PC-3) stromal cells, RT-PCR, western blot analysis, ELISA conducted. reveal function exogenous PCa AKT phosphorylation confirmed by after...
To measure changes in penile length (PL) over time before and after radical prostatectomy (RP), to investigate the underlying mechanisms for these changes.The stretched PL (SPL) of 102 patients was measured before, 10 days after, at 1, 3, 6, 9, 12, 18 24 months RP. The perpendicular distance from distal end membranous urethra midline pelvic outlet on mid-sagittal magnetic resonance imaging (MRI) slice three points: preoperatively; RP; 12 Pre- postoperative SPLs were compared using paired...
Partial nephrectomy is effective for preserving renal function, but temporary clamping of the artery hemorrhagic control may impair function due to ischemia/reperfusion injury. Anatrophic partial (APNx) has been proposed minimize injury by only feeding artery. We aimed evaluate whether anatrophic useful in and assess variations anatomy determine feasibility selective segmental clamping.We performed preoperative angiography utility APNx. Perioperative changes were compared between APNx group...
Cytosine deaminase (CD) activates prodrug 5-FC to 5-FU and is used for suicide gene therapy (the CD/5-FC system). E. coli uracil phosphoribosyltransferase (UPRT) a pyrimidine salvage enzyme that directly converts into 5-fluorouridine monophosphate improves the antitumoral effect of 5-FU. This study demonstrates effectiveness transduction UPRT in addition cancer therapy.We investigated combined human hormone independent prostate cell line DU145 using two separate adenovirus vectors expressing...
Objective: We investigated the effects of testosterone replacement therapy (TRT) on bone mineral density (BMD) among hypogonadal men with osteopenia/osteoporosis.Methods: From our previous EARTH study population, 74 patients a clinical diagnosis osteopenia or osteoporosis and hypogonadism were included in this study, as TRT (n = 35) control 34) groups. The group was administered 250 mg enanthate injection every 4 weeks for 12 months. BMD, waist circumference, body mass index, fat percentage,...
The 150-kDa oxygen-regulated protein ORP150, a new member of the heat shock family that functions as molecular chaperone in endoplasmic reticulum, was found to increase infiltrating cancer cells. Since enhancement ORP150 expression and presence vascular endothelial growth factor (VEGF) human prostate glands were immunohistochemically demonstrated, we examined whether transduced antisense cDNA can reduce angiogenicity tumorigenicity through suppression VEGF secretion.Human specimens stained...
Abstract The status of human papillomavirus (HPV) infection in urothelial inverted papilloma was examined the present study. Formalin‐fixed and paraffin‐embedded tissues from eight cases bladder were studied. presence HPV‐DNA by modified GP5/6+PCR using archival tissue sections microdissection. HPV genotype determined with a Hybri‐Max genotyping kit. Immunohistochemical analysis for p16‐INK4a, mcm7, HPV‐E4, L1, situ hybridization genome performed. detected seven (87.5%) papilloma. Three...
Objectives To investigate patient satisfaction with antimuscarinic treatment of overactive bladder syndrome, and to identify factors having a significant influence on satisfaction. Methods A cross‐sectional questionnaire survey was carried out assess among male female patients (age ≥20 years) in the H okuriku district J apan. The symptom scores, efficacies, adverse events (dry mouth constipation), scores were investigated compared using different therapeutics. Results In total, 977...
We investigated the effects of testosterone replacement therapy (TRT) on nocturia and general health among men with hypogonadism nocturia.From our previous EARTH study population, 64 patients a clinical diagnosis (two or more times per one night) hypogonadism, comprising TRT group (n = 31) controls 33), were included in this analysis. The was administered 250 mg enanthate as an intramuscular injection every 4 weeks for 6 months. All responded to following questionnaires: International...
Three different membrane-type matrix metalloproteinases (MT1, 2, and 3-MMP) that can activate proMMP-2 (progelatinase A) are thought to play an important role in invasion metastasis by various human carcinomas. To further clarify this role, we examined mRNA expression of MT-MMPs renal cell carcinomas.mRNA was extracted from 25 clinical specimens carcinoma 23 normal parenchyma remote the tumor. Reverse transcription polymerase chain reaction (RT-PCR) using specific primers performed, PCR...
It is difficult to determine the cause of high fever in patients with advanced cancer, because they tend have both neoplastic and concomitant bacterial infections elevated white blood cells C-reactive protein levels. Procalcitonin has been reported be a valuable marker for wide range clinical scenarios. However, there no studies regarding usefulness procalcitonin differentiate between febrile episodes caused by urological cancer. In present study, 37 were retrospectively analyzed. Although...
We investigated the correlation between highly sensitive C-reactive protein (hs-CRP) levels and erectile function, assessed clinical role of hs-CRP in men with late-onset hypogonadism (LOH) syndrome. For 77 participants, we Sexual Health Inventory for (SHIM) score, Aging Male Symptoms (AMS) score International Prostate Symptom Score (IPSS). also evaluated free testosterone (FT), hs-CRP, total cholesterol, triglyceride levels, high density lipoprotein hemoglobin A1c, body mass index, waist...
To evaluate the efficacy and safety of imidafenacin (IM), a novel short half-life anticholinergic, as add-on therapy for male LUTS with nocturia nocturnal polyuria.This multicenter, prospective, randomized, open-labelled study was conducted involved men who had frequency, urgency, despite receiving stable dose α1-blocker ≥1 month. Subjects were randomised to control (α1-blocker alone), IM twice/day +0.1 mg twice daily), or nightly plus 0.1 nightly) group; treatment period 8 weeks. Primary...
We performed a retrospective review of clinical T1a renal cell carcinoma patients treated in our institution. The clinicopathological findings and patients' prognoses were analyzed according to tumor size, risk factors for recurrence elucidated.A total 140 cases sporadic with diameter 4 cm or less on computed tomography preoperative evaluation as T1a. Patients underwent radical nephrectomy nephron-sparing surgery, evaluated postoperatively every 3-6 months screen metastatic disease....
Due to the low rate of screening for prostate cancer in Japan, incidence rates are high. We have established a prostate-specific antigen (PSA)-based system our region. analyzed recent trends clinical symptoms and prognosis patients aged 55 69 years old institution.Between 2000 2007, 162 cases were newly diagnosed. The study population was divided into 119 with high PSA without symptoms, 36 urological 7 systemic symptoms. courses each group.The localized disease significantly higher testing...
We investigated the effects of testosterone replacement therapy (TRT) on metabolic factors among hypogonadal men with a syndrome. From study population EARTH study, which was randomised controlled in Japan, 65 patients syndrome, comprising TRT group (n = 32) and controls 33), were included this analysis. The administered 250 mg enanthate as an intramuscular injection every 4 weeks for 12 months. Waist circumference, body mass index, fat volume blood pressure measured all at baseline In...
Most common population screening systems for prostate cancer are administered by municipal governments in Japan. These suffer from difficulties adequate follow up of patients at several urology departments the region. We analyzed clinical characteristics and outcomes detected our prostate-specific antigen (PSA)-based screen, examined efficiency system.Since 2000, we have carried out PSA-based men aged 55-69 years. For present study, primary treatments diagnosed this program were obtained...
As adult urological soft tissue sarcomas (STS) are rare, there have been few recent large-scale studies of these tumors. This report describes a single institutional experience STS over 25 years.The study population consisted patients with histologically diagnosed arising in the urinary tract, male genital system, or retroperitoneum between January 1983 and July 2008. The endpoint was overall survival. crude probability survival estimated using Kaplan-Meier method. Uni- multivariate analysis...