A5067412813- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Advanced Fluorescence Microscopy Techniques
- Fungal and yeast genetics research
- Protein Structure and Dynamics
- Cell Image Analysis Techniques
- Photosynthetic Processes and Mechanisms
- Force Microscopy Techniques and Applications
- ATP Synthase and ATPases Research
- History of Science and Medicine
- American Constitutional Law and Politics
- Plant Molecular Biology Research
- Advanced Polymer Synthesis and Characterization
- Diverse Historical and Scientific Studies
- 3D Shape Modeling and Analysis
- Glycosylation and Glycoproteins Research
- Historical Studies and Socio-cultural Analysis
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Material Dynamics and Properties
- Cardiomyopathy and Myosin Studies
- Plant Reproductive Biology
- American History and Culture
- Colonialism, slavery, and trade
- Lipid metabolism and biosynthesis
Lehigh University
2019-2023
The F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces pombe and plays a key role attaching the cytokinetic ring (CR) to plasma membrane (PM). Cdc15's abilities bind oligomerize via its domain are inhibited by phosphorylation of intrinsically disordered region (IDR). Multiple cell polarity kinases regulate IDR phosphostate, these DYRK kinase Pom1 sites on have been shown vivo prevent CR formation at tips. Here, we compared ability control phosphostate cortical...
Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive frequent destabilization near barbed ends. To investigate mechanisms behind remodeling, we created stochastic model with polymerization, depolymerization, branching, capping, uncapping, severing, oligomer diffusion, annealing, and debranching. We find enhanced ends, can explain single lifetime distribution, if fragments...
Actin is an essential element of both innate and adaptive immune systems can aid in motility translocation bacterial pathogens, making it attractive target for toxins. Pathogenic Vibrio Aeromonas genera deliver actin cross-linking domain (ACD) toxin into the cytoplasm host cell to poison regulation promptly induce rounding. At early stages toxicity, ACD covalently cross-links monomers oligomers (AOs) that bind through multivalent interactions potently inhibit several families assembly...
Pattern-forming networks have diverse roles in cell biology. Rod-shaped fission yeast cells use pattern formation to control the localization of mitotic signaling proteins and cytokinetic ring. During interphase, kinase Cdr2 forms membrane-bound multiprotein complexes termed nodes, which are positioned middle due part node inhibitor Pom1 enriched at tips. Node positioning is important for timely cycle progression Here, we combined experimental modeling approaches investigate by Pom1-Cdr2...
Abstract The F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces pombe and it plays a key role attaching the cytokinetic ring (CR) to plasma membrane. Cdc15’s abilities bind membrane oligomerize via its domain are inhibited by phosphorylation of intrinsically disordered region (IDR). Multiple cell polarity kinases regulate IDR phosphostate, these DYRK kinase Pom1 sites on have been shown vivo prevent CR formation at tips. Here, we compared ability control phosphostate...
ABSTRACT Single molecule imaging has shown that part of actin disassembles within a few seconds after incorporation into the dendritic filament network in lamellipodia, suggestive frequent destabilization near barbed ends. To investigate mechanisms behind remodeling, we created stochastic model with polymerization, depolymerization, branching, capping, uncapping, severing, oligomer diffusion, annealing, and debranching. We find enhanced ends, can explain single lifetime distribution, if...
ABSTRACT We studied actin filament polymerization and nucleation with molecular dynamics simulations a previously established coarse-grained model having each residue represented by single interaction site located at the C α atom. approximate protein as fully or partially rigid unit to identify equilibrium structural ensemble of interprotein complexes. Monomers in F-actin configuration bound both barbed pointed ends short anticipated locations for polymerization. Binding occurred similar...
The organization of the cytokinetic ring at cell equator dividing animal and fungi cells depends crucially on anillin scaffold proteins. In fission yeast, related Mid1 binds to plasma membrane helps anchor organize a medial broad band nodes, which are precursors contractile ring. Similar other anillins, contains C terminal globular domain with two potential regions for binding, Pleckstrin Homology (PH) C2 domains, an N intrinsically disordered region that is strongly regulated by...
Pattern forming networks have diverse roles in cell biology. Rod-shaped fission yeast cells use pattern formation to control the localization of mitotic signaling proteins and cytokinetic ring. During interphase, kinase Cdr2 forms membrane-bound multiprotein complexes termed nodes, which are positioned middle due part node inhibitor Pom1 enriched at tips. Node positioning is important for timely cycle progression Here, we combined experimental modeling approaches investigate by Pom1-Cdr2...
Reviewed by: Instruments of Empire: Colonial Elites and U.S. Governance in Early National Louisiana, 1803–1815 by M. K. Beauchamp Aaron R. Hall 1803–1815. By Beauchamp. (Baton Rouge: Louisiana State University Press, 2021. Pp. xiv, 314. $55.00, ISBN 978-0-8071-7428-9.) In 1803 the United States became latest empire striving to govern complex world encompassed territory Orleans. Native nations, enslaved Africans, free people color, Creole slave owners, Anglo-American settlers populated...
Reviewed by: Gray Gold: Lead Mining and Its Impact on the Natural Cultural Environment, 1700–1840 by Mark C. Chambers Aaron R. Hall (bio) Keywords Lead, Mining, Illinois, Missouri, Creoles, Native Americans 1700–1840. By Chambers. ( Knoxville: University of Tennessee Press, 2021. Pp. 258. Cloth, $65.00.) When Father Jacques Gravier traveled south through le pays de Illinois in 1700, Jesuit missionary did not discover, as he claimed, rich lead [End Page 527] deposits that lay near Kaskaskia...