A5048339253- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Complement system in diseases
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Systemic Sclerosis and Related Diseases
- Renin-Angiotensin System Studies
- Platelet Disorders and Treatments
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Apelin-related biomedical research
- Renal and related cancers
- Health and Lifestyle Studies
- Electrolyte and hormonal disorders
- Endoplasmic Reticulum Stress and Disease
- Chronic Disease Management Strategies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hormonal Regulation and Hypertension
- Connective Tissue Growth Factor Research
- Bariatric Surgery and Outcomes
- NF-κB Signaling Pathways
Austral University of Chile
2014-2024
Austral University
1992-2024
University of Tarapacá
2024
Sociedad de Biología de Chile
2022
Hospital Base
2008
Millennium Nucleus of Ion Channel Associated Diseases
2001
University of Cambridge
1996
Background. Nuclear factor-κB (NF-κB) regulates genes involved in renal disease progression, such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES. NF-κB is activated experimental models of injury, vitro studies also suggest that proteinuria angiotensin II could be important activators. It has been proposed locally produced MCP-1 may development diabetic nephropathy (DN). We examined hypothesis an indicator damage progression DN. Methods. Biopsy specimens from 11...
Cystic fibrosis (CF), a genetic disorder, is characterized by chronic pulmonary infection/inflammation which leads to respiratory failure. The presence of anti-neutrophil cytoplasmic autoantibodies (ANCA) has previously been observed in the sera patients with CF. In view known relationship ANCA primary vasculitis and their putative pathogenetic role these disorders, we studied presence, specificity isotype clinical associations 66 adult CF patients. None samples had major antigens,...
Recent evidence in vitro and vivo suggests that gremlin, a bone morphogenetic protein antagonist, is participating tubular epithelial mesenchymal transition (EMT) diabetic nephropathy as downstream mediator of TGF-beta. Since EMT also occurs parietal glomerular cells (PECs) leading to crescent formation, we hypothesized gremlin could participate this process. With aim studied its expression 30 renal biopsies patients with pauci-immune crescentic nephritis.Gremlin was detected by situ...
A growing number of patients are recognized worldwide to have chronic kidney disease. Glomerular and interstitial fibrosis hallmarks renal progression. However, the remains an unresolved challenge, its molecular mechanisms still not fully understood. Gremlin is embryogenic gene that has been shown play a key role in nephrogenesis, expression generally low normal adult kidney. gremlin elevated many human diseases, including diabetic nephropathy, pauci-immune glomerulonephritis allograft...
The albumin overload model induces proteinuria and tubulointersitial damage, followed by hypertension when rats are exposed to a hypersodic diet. To understand the effect of kinin system stimulation on salt-sensitive explore its potential renoprotective effects, was induced in Sprague-Dawley that had previously received high-potassium diet enhance activity pathway, with/without administration icatibant block B 2 receptor (B R). A disease control group but not potassium or icatibant, all...
Anticardiolipin (aCL) antibodies have been associated with thrombocytopenia, hemolytic anemia and an increased risk of thrombosis in different vascular locations, even the absence lupus. The classic hemolytic-uremic syndrome is a postinfectious acute renal failure characterized by anemia, thrombocytopenia presence widespread glomerular kidney, pathogenic mechanisms that remain to be identified. In order establish frequency aCL this identify possible role pathogenesis clinical manifestations,...
The existence and type of renal involvement influences the prognosis systemic lupus erythematosus this information may be critical when it comes to taking appropriate therapeutic decisions. To evaluate statistical correlations between clinical histological data in patients with biopsied nephropathy. Review adult kidney biopsy requests reported 2002 2014 a definitive histopathological diagnosis erythematosus. 134 cases (86% women), aged 15–59 years. Indication for biopsy: asymptomatic urinary...
Since platelet factor 4 (PF4), a cationic (pI 7.6) secretory protein, binds avidly to glomerular polyanions both in vitro and vivo, is implicated neutrophil chemotaxis, we studied by indirect immunofluorescence microscopy the presence of PF4 deposits glomeruli patients with poststreptococcal nephritis (APSGN). Goat antihuman serum was used as primary antibody fluorescein-conjugated IgG fraction rabbit antigoat second antibody. Controls consisted nonimmune goat or anti-PF4 preabsorbed human...