A5023949362- Cancer Treatment and Pharmacology
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Microtubule and mitosis dynamics
- Chemical synthesis and alkaloids
- Plasma Diagnostics and Applications
- Monoclonal and Polyclonal Antibodies Research
- Microbial Natural Products and Biosynthesis
- Antimicrobial Peptides and Activities
- Magnetic confinement fusion research
- Neuropeptides and Animal Physiology
- Ionosphere and magnetosphere dynamics
- Marine Sponges and Natural Products
- Particle accelerators and beam dynamics
- Carbohydrate Chemistry and Synthesis
- vaccines and immunoinformatics approaches
- Receptor Mechanisms and Signaling
- Phytochemistry and Bioactive Compounds
- Synthesis and Biological Activity
- Traditional and Medicinal Uses of Annonaceae
- Catalytic Processes in Materials Science
- Helicobacter pylori-related gastroenterology studies
- Supramolecular Self-Assembly in Materials
- RNA and protein synthesis mechanisms
- Blood Coagulation and Thrombosis Mechanisms
ETH Zurich
2009-2023
Board of the Swiss Federal Institutes of Technology
2011
The University of Queensland
2005-2010
École Polytechnique Fédérale de Lausanne
1966-2010
Servier (France)
2008
Max Planck Institute for Biophysical Chemistry
2008
Hacettepe University
2007
University of Zurich
1999-2003
Swiss Tropical and Public Health Institute
2001
Université de Lorraine
1998
The paper describes the first three deaths reported in Europe involved isotonitazene consumption, a potent benzimidazole derivate opioid consumed recreational drug scene. Isotonitazene powder and purity determination was performed on sample collected death scene by NMR, HRMS, GC-FTIR, ATR-FTIR GC–MS. determined GC–MS analysis proton defined to be above 95 % 98 %, respectively. Quantification of biological samples using targeted based SPE extraction ultra-high performance liquid...
Analyses of high resolution crystal structures have shown that antibody hypervariable loops L1, L2, and L3 from the light chain, as well H1 H2 heavy can be assigned to only a small family canonical conformations. We describe here attempts generate structural mimetics L3, conformations, which are β-hairpin connecting adjacent antiparallel β-strands. The five studied comprise cyclic peptides, in CDR loop has been transplanted immunoglobulin framework onto d-Pro-l-Pro template. Their preferred...
Abstract Sustained identification of innovative chemical entities is key for the success biology and drug discovery. We report fragment‐based, computer‐assisted de novo design a small molecule inhibiting Helicobacter pylori HtrA protease. Molecular binding designed compound to was confirmed through biophysical methods, supporting its functional activity in vitro. Hit expansion led currently best‐in‐class inhibitor. The results obtained reinforce validity ligand‐based binding‐kinetics‐guided...
Interfering with interferon: A low-molecular-weight inhibitor has been discovered that blocks the interaction between interferon-α (IFN-α) and its receptor (see picture for a model of interfaces). The resulting lead compound significantly reduces IFN-α production in vitro. NMR SPR experiments confirm direct IFN-α.
The conformational properties of the microtubule-stabilizing agent epothilone A (1a) and its 3-deoxy 3-deoxy-2,3-didehydro derivatives 2 3 have been investigated in aqueous solution by a combination NMR spectroscopic methods, Monte Carlo searches, NAMFIS calculations. tubulin-bound conformation (1a), as previously proposed on basis data, was found to represent significant fraction ensemble conformations present for free ligands solution.
Abstract Specific interactions of peptides with lipid membranes are essential for cellular communication and constitute a central aspect the innate host defense against pathogens. A computational method generating innovative membrane‐pore‐forming inspired by natural templates is presented. Peptide representation in terms sequence‐ topology‐dependent hydrophobic moments introduced. This design concept proves to be appropriate de novo generation first‐in‐class membrane‐active anticipated mode...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT3,4-Dihydro-3-amino-2H-1-benzopyran Derivatives as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents. 1. Synthesis Structure-Activity Relationship StudiesTchao Podona, Beatrice Guardiola-Lemaitre, Daniel-Henri Caignard, Gerard Adam, Bruno Pfeiffer, Pierre Renard, Gerald GuillaumetCite this: J. Med. Chem. 1994, 37, 12, 1779–1793Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June...
The complete electromagnetic field has been calculated within a homogeneous infinite two-dimensional plasma sheath with perpendicularly applied static magnetic field. is produced by high-frequency at the surface. When electron-cyclotron frequency greater than of surface, refractive index medium becomes real for right-hand polarized wave and one an increased penetration energy into interior plasma. It also possible to reach value such that thickness half wavelength. In this case, resonance...
An optimized cyclic peptidomimetic (see picture) of the NPNA-repeat region in circumsporozoite (CS) protein P. falciparum was designed. When delivered to immune system on human-compatible viruslike particles (virosomes), mimetic effectively elicits sporozoite-binding antibodies. This virosome-mimotope (virotope) approach may be general value for design and testing new synthetic-vaccine candidates. Supporting information this article is available WWW under...
Together with ten well known compounds, the quinic acid derivative chlorogenic acid, nucleoside adenosine, two amino acids, tryptophan and phenylalanine, anthraquinone derivatives, aloemodin, aloemodin acetate chyrosphanol 1-O-gentiobioside, flavon C-glycosides, isovitexin, isoorientin 4’-O-β -glucopyranoside, as new acylated 6”-O-(malonyl)-isoorientin 6”-O-[(S)-3-hydroxy-3-methylglutaroyl]-isoorientin, were isolated from water soluble part of methanolic extract fresh leaves Asphodelus...
Certain cationic peptides interact with biological membranes. These often-complex interactions can result in peptide targeting to the membrane, or membrane permeation, rupture, and cell lysis. We investigated relationship between structural features of membrane-active these effects, better understand processes. To this end, we employed a computational method for morphing membranolytic antimicrobial into nonmembranolytic mitochondrial by "directed simulated evolution." The results obtained...
The high-frequency magnetic fields within a homogeneous plasma sheath were measured as function of the parameters and perpendicularly superimposed static field. These are compared with those calculated taking collision into account. A theoretically predicted resonance electron cyclotron wave is observed. Investigations on an electrodeless ring discharge field perpendicular to axis also exhibit similar behavior which in literature was first reported 1948. However valid physical explanation...
Mycolactones A/B (1a/b) are exotoxins of Mycobacterium ulcerans that the molecular cause Buruli ulcer. 1a/b represent a rapidly equilibrating mixture Z/E isomers about C4′═C5′ double bond C5-side chain. Here, we describe syntheses mycolactone analogs with configurationally stable chains (2a, E mimetic; 2b/c, Z mimetics). Based on cytotoxicity 2a–c, Δ4′,5′-trans isomer mycolactones (1b) appears to be major virulence factor.
Abstract The tubulin‐binding mode of C3‐ and C15‐modified analogues epothilone A (Epo A) was determined by NMR spectroscopy computational methods compared with the existing structural models tubulin‐bound natural Epo A. Only minor differences were observed in conformation macrocycle between C3‐modified investigated. In particular, 3‐deoxy‐ (compound 2 ) 3‐deoxy‐2,3‐didehydro‐Epo ( 3 found to adopt similar conformations cleft as A, thus indicating that 3‐OH group is not essential for...
Abstract Es wird über die im System Pr 2 O 3 –Tb in Abhängigkeit von der Temperature auftretenden Mischphasen berichtet. Bei 550°C erhält man eine lückenlose Mischkristallreihe vom C‐Typ. Temperaturen zwischen 900 und 1600°C treten drei bekannten Strukturtypen A, B C sowie Zweiphasengebiete auf. Die B‐Form des Terbiumsesquioxids konnte unter Wasserstoffatmosphäre schon bei relativ niedrigen Temperatur beobachtet werden.