A5037192173- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Research on Leishmaniasis Studies
- Helminth infection and control
- Trypanosoma species research and implications
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Radiopharmaceutical Chemistry and Applications
- Drug-Induced Hepatotoxicity and Protection
- Bacterial Genetics and Biotechnology
- Methane Hydrates and Related Phenomena
- Alkaline Phosphatase Research Studies
- Pharmacological Effects and Toxicity Studies
- Child Nutrition and Water Access
- Primate Behavior and Ecology
- Livestock and Poultry Management
- Vitamin K Research Studies
- Virology and Viral Diseases
- Bacteriophages and microbial interactions
- T-cell and Retrovirus Studies
- Peptidase Inhibition and Analysis
- Insect Pest Control Strategies
- Zoonotic diseases and public health
- Vector-borne infectious diseases
- Insect Resistance and Genetics
University of California, San Francisco
2019-2022
QB3
2020
Aultman Hospital
2018
Ursinus College
2017
National University of Rosario
2012
Hospital de Clínicas da Unicamp
2009
Franklin & Marshall College
1983
Universidade Federal de Minas Gerais
1968-1980
Fundação Oswaldo Cruz
1977-1978
Instituto de Ciencias Tecnológicas
1972
SummaryIn mice experimentally infected with Schistosoma mansoni, oviposition starts round the 30th day of infection. Eggs are immature when laid and about 6 days necessary for embryo to reach miracidial stage. A few after maturation eggs intestinal lumen eliminated feces. Schistosomal elements (eggs, shell, parasitic nodules) found in intestine untreated S. mansoni were described. When percentage schistosomal (oogram) between 38th 70th infection was investigated, it that almost all viable...
Sense and respond Many signaling pathways start with cellular proteins sensing responding to small molecules. Despite advances in protein design, creating a protein-based sense-and-respond system remains challenging. Glasgow et al. designed binding sites at the interface of heterodimers (see Perspective by Chica). By fusing each monomer one half split reporter, they linked ligand-driven dimerization reporter output. The computational design strategy provides generalizable approach create...
SummaryThe efficiency of the oogram method for primary screening drugs in schistosomiasis has been assessed with known schistosomicides that included 7 antimonials, 8 xanthone derivatives, 2 p-aminophenoxyalkane emetine and 4 other compounds. The were administered, 5 consecutive days, to mice experimentally infected Schistosoma mansoni, daily dose being one-fifth one-fourth LD50's. animals sacrificed 3 days after end treatment. All have found produce changes (i.e., relative proportions eggs...
Background Blood samples from patients with sickle cell disease (SCD) present to transfusion service numerous antibodies, making the searching for compatible red blood cells (RBC) a challenge. To overcome this problem we developed an effective strategy meet needs of supplying RBC‐compatible units SCD using DNA arrays. Methods We selected 144 multiple (receiving > 5 units) transfusions previously phenotyped ABO, Rh(D, C, c, E, e), K1, Fy and Jk . also 948 Brazilian donors whose ABO/RhD...
The occurrence of all- trans (-)-14,15-epoxygeranyl-geraniol in Pterodon pubescens Benth. is established, and its prophylactic activity against infection by Schitsosma mansoni demonstrated. Two other diterpenes present the oil are inactive.
SummaryIntradermal tests conducted in Brazil were made with antigens prepared the United States from schistosome material collected Puerto Rico and obtained Brazil. No significant difference activity was noted when nitrogen content of adjusted to same levels.Tests indicate that skin test is not very sensitive detecting infections children below 5 years age, girls are less reactive than boys, women men. Tests performed on both arm back found be more site for testing. Women tested scapular...
Skin penetration by Schistosoma mansoni cercariae may be blocked 1,4-and 1,2-naphthoquinones applied topically. Of 23 naphthoquinone derivatives synthesized, 15 afforded almost complete protection when in solution to the tails of mice 24 hours before exposure cercariae. On basis present evidence 5-carbon atom side chain naturally occurring lapachol seems important for activity, and this is accord with previous observation that effective protective agents are liposoluble. Topically cercarial...
Abstract The wood oils of the trees Eremanthus elaeagnus Sch.-Bip., Vanillosmopsis erythropappa Sch.-Bip. and Moquinea velutina Bong. inhibit penetration cercariae trematode Schistosoma mansoni. effect is due to presence α,β-unsaturated sesquiterpene lactones which three, eremanthine (I), costunolide (III) α-cyclocostunolide (V), have been characterized. alcohol (-)-bisabolol (II) present in two weakly active while dihydro-β-cyclocostunolide (VI) lacks unsaturated lactone function inactive....
Clinical trials with hycanthone, an active metabolite of lucanthone, were performed in 203 patients schistosomiasis mansoni. The drug was administered the form enterocoated tablets and by intramuscular injection (sulfamate methanesulfonate salts). Anorexia, nausea, vomiting, abdominal pain, headache, muscle loss body weight commonest side-effects. In all but six patients, treatment could be completed. With parenteral formulations no interruption necessary. Alterations plasma-level...