A5073820582- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Microbial Inactivation Methods
- Prostate Cancer Diagnosis and Treatment
- Lymphatic System and Diseases
- Colorectal Cancer Treatments and Studies
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Body Composition Measurement Techniques
- Cancer Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Cardiac tumors and thrombi
- Nutrition and Health in Aging
- Lymphoma Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Melanoma and MAPK Pathways
- Medical Imaging and Pathology Studies
Herlev Hospital
2012-2025
Copenhagen University Hospital
2014-2025
Tel Aviv University
2024
Rabin Medical Center
2024
Gentofte Hospital
2016-2024
University of Copenhagen
1995-2022
Technical University of Denmark
2012
Nordic Lymphoma Group
2007
Rigshospitalet
1995-2003
Hvidovre Hospital
1995-2002
Abstract Background Postoperative organ dysfunction contributes to morbidity, hospital stay and convalescence. Multimodal rehabilitation with epidural analgesia, early oral feeding, mobilization laxative use after colonic resection has reduced ileus stay. Methods Fourteen patients receiving conventional care (group 1) 14 who had multimodal 2) were studied before 8 days resection. Outcome measures included postoperative mobilization, body composition by whole-body dual X-ray absorptiometry,...
Abstract Purpose: Adoptive cell transfer therapy (ACT) based on autologous tumor-infiltrating lymphocytes (TIL) has achieved impressive clinical results in several phase I and II trials performed outside of Europe. Although transient, the toxicities associated with high-dose (HD) bolus IL2 classically administered together TILs are severe. To further scrutinize whether similar can be lower doses IL2, we have carried out a I/II trial TIL after classical lymphodepleting chemotherapy followed...
Abstract Anti-programmed death (PD)-1 (aPD1) therapy is an effective treatment for metastatic melanoma (MM); however, over 50% of patients progress due to resistance. We tested a first-in-class immune-modulatory vaccine (IO102/IO103) against indoleamine 2,3-dioxygenase (IDO) and PD ligand 1 (PD-L1), targeting immunosuppressive cells tumor expressing IDO and/or PD-L1 (IDO/PD-L1), combined with nivolumab. Thirty aPD1 therapy-naive MM were treated in phase 1/2 study (...
Background. Cutaneous recurrences of breast cancer may cause considerable discomfort due to ulceration, oozing, and pain can also be difficult treat. Electrochemotherapy is a localised anticancer treatment using electric pulses make cell membranes permeable, augmenting uptake chemotherapeutic drugs, thus enabling highly efficient tumour kill. This the first systematic investigation electrochemotherapy for larger cutaneous cancer. Patients methods. We conducted phase II trial patients with...
Objective:Ovarian cancer (OC) is often diagnosed at an advanced stage with two thirds of patients experiencing recurrent disease a poor prognosis. Adoptive cell therapy (ACT) tumor-infiltrating lymphocytes (TIL) has shown curative potential in malignant melanoma, but only been investigated scarcely other cancers. In this pilot study, we tested TIL based ACT metastatic OC.Methods:Six progressive platinum-resistant OC were treated infusion preceded by standard lymphodepleting chemotherapy and...
To ensure optimal treatment and surveillance of patients with melanoma, knowledge the clinical stage-specific risk recurrence, mortality, recurrence patterns across American Joint Committee on Cancer Eighth Edition (AJCC8) substages is needed.
Background: Following treatment for breast cancer 12%–60% develop cancer-related lymphedema (BCRL). There are several ways of assessing BCRL. Circumference measurement (CM) and water displacement (WD) volume measurements (VM) frequently used methods in practice research, respectively. The aim this study was to evaluate CM WD VM the BCRL arm contralateral arm, comparing results with regional dual energy X-ray absorptiometry (DXA). Methods Results: Twenty-four women unilateral were included...
The study aim was to compare European Organization for Research and Treatment of Cancer (EORTC) criteria with PET Response Criteria in Solid Tumors (PERCIST) response evaluation patients metastatic colorectal cancer treated a combination the chemotherapeutic drug irinotecan monoclonal antibody cetuximab. <b>Methods:</b> From 2006 2009, were prospectively included phase II trial evaluating cetuximab every second week, as third-line treatment. <sup>18</sup>F-FDG PET/CT performed between 1 14 d...
Almost half of the patients with metastatic melanoma obtain only short-term or no benefit at all from checkpoint inhibitor (CPI) immunotherapy. In this study, we investigated whether immune system progressing following CPI treatment was able to generate functional tumor-specific responses.Tumor-infiltrating lymphocytes (TILs) were isolated and expanded lesions which progressed during after anti-programmed cell death protein 1 (PD)-1 anti-Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) treatment....
Introduction: Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has proved to be an effective treatment for metastatic melanoma, even in patients failing anti-PD-1 blockade. Nevertheless, progression is observed a substantial subgroup of following initial objective response with TILs. These might benefit from additional consolidating before clinical progression, but thus far, it not possible identify this prone progress. In study the predictive value early metabolic after TIL...
We evaluated the predictive value of interim positon emission tomography (I-PET) after one course chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve DLBCL were enrolled. All had PET/computed (CT) scans performed chemotherapy (PET-1). I-PET categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) scores 1–3 considered negative 5PS > 3) D 1–4 = 5). Ratios tumor maximum...
Objective To investigate the skeletal muscle mitochondrial function in HIV-infected patients with lipdystrophy or elevated p-lactate levels. Design Eight HIV treated highly active antiretroviral therapy, lipodystrophy p-lactate, and eight healthy controls were exposed to incremental exercise until exhaustion. Methods Blood samples gas analysis performed at rest, during recovery. Oxygen consumption, workload blood lactate assessed. Before immediately after biopsies obtained, which citrate...
Despite impressive response rates following adoptive transfer of autologous tumor-infiltrating lymphocytes (TILs) in patients with metastatic melanoma, improvement is needed to increase the efficacy and broaden applicability this treatment. We evaluated use vemurafenib, a small-molecule BRAF inhibitor immunomodulatory properties, as priming before TIL harvest T cell therapy phase I/II clinical trial. 12 were treated vemurafenib for 7 days tumor excision during weeks until infusion. TILs...
A total of 16 obese women (body mass index (BMI) 30–43 kg m−2) participated in a weight reduction study. Before and after loss 11.7±7.4 (mean±SD), body composition was assessed by dual energy X-ray absorptiometry (DXA), potassium counting (TBK). These measurements were compared with bioimpedance analysis (BIA) applying 11 predictive BIA equations published the literature. Predictive for present study population developed, use fat-free (FFM) as TBK DXA references multiple regression...
SUMMARY Aim To evaluate the long‐term effect of changes in body composition induced by weight loss on insulin sensitivity (S I ), non‐insulin mediated glucose disposal, effectiveness G ) and β‐cell function. Design Glucose metabolism was evaluated before after participation a two‐year trial Orlistat vs. placebo, combined with an energy fat restricted diet. Subjects Twelve obese patients (11 women, 1 man), age 45.8 ± 10.5 years, (BW) 99.7 13.3 kg, BMI 35.3 2.8 kg/m 2 . Measurements At...