About
Contact & Profiles
A5101658583
Research Areas
- Redox biology and oxidative stress
- Connexins and lens biology
- Mitochondrial Function and Pathology
Wayne State University
2019
Thioredoxin-interacting protein (TXNIP) plays a critical role in oxidative stress, inflammation, apoptosis and the pathogenesis of diabetic retinopathy (DR). However, TXNIP high glucose-induced retinal pigment epithelium (RPE) dysfunction is still unknown. Here, we show that glucose (HG; 25 mM,) significantly increases expression at both mRNA levels when compared to low (LG; 5.5 mM) human RPE cell line (ARPE-19) primary (HRPE) cells. upregulation associated with mitochondrial membrane...
10.1242/bio.038521
article
EN
cc-by
Biology Open
2019-01-01
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