A5008998108- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced X-ray Imaging Techniques
- AI in cancer detection
- Diet and metabolism studies
- Prostate Cancer Diagnosis and Treatment
- Digital Holography and Microscopy
- Liver Disease Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Adipose Tissue and Metabolism
- Advanced MRI Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cell Image Analysis Techniques
- Nutritional Studies and Diet
- Growth Hormone and Insulin-like Growth Factors
- Advanced Neuroimaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Ovarian function and disorders
- Glioma Diagnosis and Treatment
- Digital Imaging for Blood Diseases
- Bariatric Surgery and Outcomes
- Celiac Disease Research and Management
- Digital Radiography and Breast Imaging
- Effects and risks of endocrine disrupting chemicals
- Pancreatic and Hepatic Oncology Research
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
SDN Istituto di Ricerca Diagnostica e Nucleare
2019-2023
Synesis
2023
University of Naples Federico II
2011-2013
Ospedale Monaldi
2012
Ospedale San Giovanni Bosco
2012
Federico II University Hospital
2011
Abstract Advancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical from diagnostic domains such as clinical imaging, pathology, next-generation sequencing (NGS), which help characterize individual differences patients. However, this information needs to be available suitable promote support scientific research technological development, supporting the effective adoption precision medicine approach practice. Digital biobanks can...
Bisphenol A, one of the highest-volume chemicals currently available, is known to act as endocrine disruptor and alters several metabolic functions, including inflammatory pathways. Elevated serum levels bisphenol A have been found in women with polycystic ovary syndrome (PCOS) a role low-grade chronic inflammation has recently reported pathogenesis this syndrome. Increased spleen volume, reliable stable index inflammation, was strictly associated severity hepatic steatosis (HS) obese...
Abstract Despite the key-role of Prostate Imaging and Reporting Data System (PI-RADS) in diagnosis characterization prostate cancer (PCa), this system remains to be affected by several limitations, primarily associated with interpretation equivocal PI-RADS 3 lesions debated role Dynamic Contrast Enhanced-Magnetic Resonance (DCE-MRI), which is only used upgrade peripheral category 4 if enhancement focal. We aimed at investigating usefulness radiomics for detection PCa (Gleason Score ≥ 6)...
Background: Non-alcoholic liver steatosis (NAS) results from an imbalance between hepatic lipid storage, disposal, and partitioning. A multifactorial diet high in fiber, monounsaturated fatty acids (MUFAs), n-6 n-3 polyunsaturated (PUFAs), polyphenols, vitamins D, E, C reduces NAS people with type 2 diabetes (T2D) by 40% compared to a MUFA-rich diet. We evaluated whether dietary effects on are mediated changes de novo lipogenesis (DNL), stearoyl-CoA desaturase (SCD1) activity, and/or...
Background and objectivesThe detection of tumor-infiltrating lymphocytes (TILs) could aid in the development objective measures infiltration grade can support decision-making breast cancer (BC). However, manual quantification TILs BC histopathological whole slide images (WSI) is currently based on a visual assessment, thus resulting not standardized, reproducible, time-consuming for pathologists. In this work, novel pathomic approach, aimed to apply high-throughput image feature extraction...
The role of dynamic contrast-enhanced-MRI (DCE-MRI) for Prostate Imaging-Reporting and Data System (PI-RADS) scoring is a controversial topic. In this retrospective study, we aimed to measure the added value DCE-MRI in combination with T2-weighted (T2W) diffusion-weighted imaging (DWI) using PI-RADS v2.1, terms reproducibility diagnostic accuracy, detection prostate cancer (PCa) clinically significant PCa (CS-PCa, Gleason Score ≥ 7). 117 lesions 111 patients were identified as suspicion by...
Kidney microscopy is a mainstay in studying the morphological structure, physiology and pathology of kidney tissues, as histology provides important results for reliable diagnosis. A modality providing at same time high-resolution images wide field view could be very useful analyzing whole architecture functioning renal tissue. Recently, Fourier Ptychography (FP) has been proofed to yield biology samples such tissues vitro cells while high resolution large view, thus making it unique...
Achieving microscopy with large space-bandwidth products plays a key role in diagnostic imaging and is widely significant the overall field of clinical practice. Among quantitative techniques, Fourier Ptychography (FP) provides wide view high-resolution images, suitable to histopathological field, but onerous computational terms. Artificial intelligence can be solution this sense. In particular, research delves into application Generative Adversarial Networks (GAN) for dual-channel complex...
Polycystic ovary syndrome (PCOS) is frequently associated with hypovitaminosis D. Vitamin D endowed pleiotropic effects, including insulin resistance (IR) and apoptotic pathway. Disruption of the complex mechanism that regulated ovarian apoptosis has been reported in PCOS. Phosphoprotein enriched diabetes gene product (PED/PEA-15), an anti-apoptotic protein involved type 2 mellitus (T2DM), overexpressed PCOS women, independently obesity. Leptin-to-adiponectin ratio (L/A) a biomarker IR...
The diagnostic imaging field is experiencing considerable growth, followed by increasing production of massive amounts data. lack standardization and privacy concerns are considered the main barriers to big data capitalization. This work aims verify whether advanced features DICOM standard, beyond storage, effectively used in research practice. issue will be analyzed investigating publicly shared medical databases assessing how much most common software tools support all its potential....
Hepatocellular carcinoma (HCC) is the most common form of liver cancer. Radiomics a promising tool that may increase value magnetic resonance imaging (MRI) in management HCC. The purpose our study to develop an MRI-based radiomics approach preoperatively detect HCC and predict its histological grade. Thirty-eight patients at staging who underwent axial T2-weighted dynamic contrast-enhanced MRI (DCE-MRI) were considered. Three-dimensional volumes interest (VOIs) manually placed on lesions...
Glioblastoma multiforme (GBM) typically exhibits substantial intratumoral heterogeneity at both microscopic and radiological resolution scales. Diffusion Weighted Imaging (DWI) dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) are two functional MRI techniques that commonly employed in clinic for the assessment of GBM tumor characteristics. This work presents initial results aiming determining if radiomics features extracted from preoperative ADC maps post-contrast T1 (T1C)...
Prostate cancer (PCa) is a disease affecting an increasing number of men worldwide. Several efforts have been made to identify imaging biomarkers non-invasively detect and characterize PCa, with substantial improvements thanks multiparametric Magnetic Resonance Imaging (mpMRI). In recent years, diffusion kurtosis (DKI) was proposed be directly related tissue physiological pathological characteristic, while the radiomic approach proven key method study phenotypes. Our aim compare standard...
Breast cancer is one of the most spread and monitored pathologies in high-income countries. After breast biopsy, histological tissue stored paraffin, sectioned mounted. Conventional inspection slides under benchtop light microscopes involves paraffin removal staining, typically with H&E. Then, expert pathologists are called to judge stained slides. However, staining operator-dependent, time resources consuming processes that can generate ambiguities due non-uniform staining. Here we propose...
Breast Cancer (BC) is the most common cancer among women worldwide and characterized by intra- inter-tumor heterogeneity that strongly contributes towards its poor prognosis. The Estrogen Receptor (ER), Progesterone (PR), Human Epidermal Growth Factor 2 (HER2), Ki67 antigen are examined markers depicting BC have been shown to a strong impact on Radiomics can noninvasively predict through quantitative evaluation of medical images, such as Magnetic Resonance Imaging (MRI), which has become...
Introduction Treatment options for non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2D) are still a matter of debate. We compared the effects diet including different components versus proven beneficial rich monounsaturated acids (MUFAs) on fat T2D. Research design and methods According to parallel design, 49 individuals T2D, overweight/obese, high waist circumference, 35–75 years-old, satisfactory blood glucose control or drugs not affecting content, were...
Pooling radiomic features coming from different centers in a statistical framework is challenging due to the variability scanner models, acquisition protocols, and reconstruction settings. To remove technical variability, commonly called batch effects, harmonization strategies have been widely used genomics but less considered radiomics. The aim of this work was develop analysis facilitate multicenter extracted prostate T2-weighted magnetic resonance imaging (MRI) improve power radiomics for...
OBJECTIVE To compare the effect of an isocaloric multifactorial diet with a rich in monounsaturated fatty acids (MUFA) and similar macronutrient composition on pancreatic fat (PF) postprandial insulin response type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS According to randomized controlled parallel-group design, 39 individuals T2D, 35–75 years old, satisfactory blood glucose control, were assigned 8 week intervention MUFA, polyunsaturated acids, fiber, polyphenols, vitamins (n = 18) or...