A5103219002- Oral microbiology and periodontitis research
- Extracellular vesicles in disease
- S100 Proteins and Annexins
- Apelin-related biomedical research
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Neurobiology and Insect Physiology Research
- Electrospun Nanofibers in Biomedical Applications
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Immune Response and Inflammation
- Wound Healing and Treatments
- Oral health in cancer treatment
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Diabetes and associated disorders
- Infective Endocarditis Diagnosis and Management
- Oral Health Pathology and Treatment
Wuhan University
2023-2025
Zhongnan Hospital of Wuhan University
2025
Abstract Tumor‒host interaction plays a critical role in malignant tumor-induced organ wasting across multiple species. Despite known regulation of regional individual peripheral organs by tumors, whether and how tumors utilize host catabolic hormone(s) to simultaneously induce systemic wasting, is largely unknown. Using the conserved yki 3SA -tumor model Drosophila , we discovered that increase production adipokinetic hormone (Akh), glucagon-like hormone, cause including muscle dysfunction,...
Cementum, a thin layer of mineralized tissue covering tooth root surface, is recognized as the golden standard in periodontal regeneration. However, current efforts mainly focus on alveolar bone regeneration rather than cementum regeneration, and rarely take Porphyromonas gingivalis (Pg), keystone pathogen responsible for destruction, into consideration. Though M2 macrophage-derived exosomes (M2-EXO) show promise exosome-producing macrophages are induced by exogenous cytokines with...
ABSTRACT The keystone pathogen Porphyromonas gingivalis (P.g.) is responsible for cementum resorption in periodontitis; however, the mechanism involved it remains unclear. Sirtuin 3 (Sirt3) a NAD + ‐dependent protein deacetylase contributing to mitochondrial homeostasis and various cell functions. In this study, expression of Sirt3 cementoblasts was found be increased during cementoblast mineralisation development, while decreased gradually under P.g. infection multiplicity...
Abstract Objective Inflammatory stimuli compromise the differentiation potency of human periodontal ligament cells (hPDLCs). Macrophage‐derived exosomes (M‐Exo) play a role in several aspects cellular activity. This study investigated how M‐Exo contributes to osteo‐/cementogenic hPDLCs under inflammation and mechanism involved. Methods was identified by transmission electron microscopy, western blotting (WB), dynamic light scattering. The internalization observed. After treatment, markers...
BACKGROUND: Apoptotic vesicles (ApoVs), which are extracellular released by apoptotic cells, have been reported to exhibit substantial therapeutic potential for inflammatory diseases and tissue regeneration. While extensive research has dedicated mesenchymal stem cells (MSCs), the investigation into immune cell-derived ApoVs remains limited, particularly regarding function fate of macrophage-derived in context periodontitis (PD).
Abstract Tumor-host interaction plays a critical role in malignant tumor-induced organ wasting across multiple species. Despite known regulation of regional individual peripheral organs by tumors, whether and how tumors utilize host catabolic hormone(s) to simultaneously induce systemic wasting, however, is largely unknown. Using the conserved yki 3SA -tumor model Drosophila , we discovered that increase production adipokinetic hormone (Akh), glucagon-like hormone, cause including muscle...