A5101569983- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Paraoxonase enzyme and polymorphisms
- Cerebrovascular and Carotid Artery Diseases
- Cynara cardunculus studies
- Biochemical Acid Research Studies
- Lipoproteins and Cardiovascular Health
- Peripheral Artery Disease Management
- Oral microbiology and periodontitis research
- Amino Acid Enzymes and Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hormonal Regulation and Hypertension
- Antioxidant Activity and Oxidative Stress
- Heart Rate Variability and Autonomic Control
- Polyamine Metabolism and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Drug Transport and Resistance Mechanisms
- Hibiscus Plant Research Studies
- Dialysis and Renal Disease Management
- Lipid metabolism and disorders
- Cardiac Imaging and Diagnostics
- Ultrasound and Hyperthermia Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Chemical Synthesis and Analysis
- Coenzyme Q10 studies and effects
Jichi Medical University
2013-2024
Touro University California
2010-2015
Jichi Medical University Hospital
2010-2015
Kyoto Medical Center
2012
Tottori University
2000-2007
Miwa Hospital
1994
Tottori Prefectural Central Hospital
1994
Ehime University
1986-1991
In this review we summarize the findings from literature and our own laboratory on decreased PON1 activity in renal failure, mechanisms proposed effect of interventions. addition to profound alterations lipoproteins, reduced serum has been clearly established past decade could contribute accelerated development atherosclerosis ESRD HD. lactonase is lower patients. Hemodialysis partially restores other activities. recovery after dialysis suggests that uremic toxins may play a mechanistic role...
The mechanism of paraoxonase 1 (PON1) atheroprotective remains elusive. lactonizing/lactonase activity PON1 is gaining favor as the most significant in physiology.We studied 42 end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) and 49 control subjects. We measured lactonase, arylesterase triesterase activities by kinetic methods.Serum lactonase was 11% lower ESRD (p<0.0001) did not correlate with high-density lipoprotein (HDL) cholesterol when controlling for confounders....
Endothelial dysfunction is found in hypertensive patients and may serve as a prognostic marker of future cardiovascular events. function can be assessed noninvasively by flow-mediated vasodilation (FMD). The goal this paper to summarize comprehensively the clinical trials that investigated effects antihypertensive drugs on endothelial FMD patients. A PubMed-based search 38 trial papers published from January 1999 June 2011. Significant improvement after treatment was shown 43 71...
<i>Objective:</i> It was the aim of this study to investigate whether there is any relationship between oxidative stress, as assessed by diacron reactive oxygen metabolite (d-ROM) test, and carotid atherosclerosis among hypercholesterolemic patients. <i>Subjects Methods:</i> A well-defined group patients with type II hypercholesterolemia (n = 81, mean age 59 years) studied observe correlation levels serum d-ROMs artery intima-media thickness (IMT) using B-mode...
Diabetic polyneuropathy (DPN) and endothelial dysfunction are prevalent complications of diabetes mellitus. Currently, there two non-invasive markers for dysfunction: flow-mediated dilation reactive hyperaemia peripheral arterial tonometry (RH-PAT). However, the relationship between diabetic small fibre neuropathy macroangiopathy remains obscure thus far. Corneal confocal microscopy (CCM) has emerged as a new diagnostic modality to assess DPN, especially fibre. To clarify vascular...
The cardio-ankle vascular index (CAVI) is used to test function and an arterial stiffness marker potential predictor of cardiovascular events. This study aimed analyze the relation between objective indices diabetic polyneuropathy (DPN) CAVI. One hundred sixty-six patients with type 2 diabetes mellitus were included in this study. We nerve conduction studies (NCSs) coefficient variation R-R interval evaluate DPN. estimated arteriosclerosis by Simple multiple linear regression analyses...
Abstract Circulating ApolipoproteinL1 (ApoL1) is a component of pre-β-high-density lipoprotein (HDL), however little known about the relationship ApoL1 with cardiometabolic factors. Considering previous studies reporting correlation to triglyceride, we have hypothesized that associates insulin-related metabolism. The current study examined their associations in 126 non-diabetic subjects and 36 patients type 2 diabetes (T2DM). Non-diabetic demonstrated triglyceride (standardized coefficients...
This study was performed to examine the role of endothelial constitutive NO synthase (ecNOS) gene in patients with abdominal aortic aneurysm (AAA).We determined distributions polymorphism intron 4 ecNOS (ecNOS4) gene, amplified by polymerase chain reaction, and compared allele frequencies between subjects aneurysms (AAAs) healthy individuals.Fifty-eight AAAs 410 race-matched controls were studied.Two alleles ecNOS4 containing (a-allele) 5 (b-allele) repeats, identified. We found that...
Aim: Cardiovascular disease is becoming increasingly more problematic in Mongolia. The cardioankle vascular index (CAVI) and circulating C-reactive protein (CRP) are new atherosclerosis-related parameters, but no comparative studies of atherosclerotic parameters including CAVI CRP available between Mongolian Japanese populations, such as populations hypertension (HT) diabetes mellitus (DM). Our study objective was to examine profiles HT DM patients both countries.Methods: From a...
To date, there are very few clinical reports that have compared the effects of ezetimibe on lipid parameters between hypercholesterolemic patients with and without type 2 diabetes mellitus (T2DM). In this study, we recruited for groups T2DM (n = 42; men/women 24/18; HbA1c 6.7 ± 5.4%) 21; 7/14; 5.3 0.4%). Patients were prescribed at a dose 10 mg/daily course 12-week study. At baseline after 12 weeks treatment, several parameters, including serum low-density-lipoprotein cholesterol (LDL-C),...
OBJECTIVE: Paraoxonase-1 (PON1) is a high-density lipoprotein-associated antioxidant enzyme. The Q192R polymorphism of the PON1 gene can protect against oxidative conditions, but relationship between and stress-related markers remains controversial. In this study, diacron reactive oxygen metabolites (d-ROMs) test was used to investigate in Japanese subjects. METHODS: Patients without history overt cardiovascular disease who were not receiving medication enrolled cross-sectional clinic-based...
Increased blood pressure and hypertension are a major atherosclerotic risk factor. Arterial stiffness is recognized to be reflective the states. The pulse wave velocity (PWV) noninvasive, simple, easy reproducible index that can used assess arterial in association with pressure. cardio-ankle vascular (CAVI) has recently been developed evaluate similarly PWV, but theoretically, this less influenced by There have several clinical reports on use of CAVI patients hypertension. levels reported...
Arterial stiffness is a surrogate indicator for the development of cardiovascular disease.The cardio-ankle vascular index (CAVI) recently developed clinical metric evaluating arterial stiffness.Two characteristics CAVI, which makes it amenable widespread use, its simplicity measurement and fact that relatively independent blood pressure.Several recent studies have shown possible utility CAVI identifying patients at high risk disease monitoring treatment effectiveness in lipid clinics.
Aim: The aim of this study was to investigate the relationship between atherosclerotic manifestations and brachial radial arterial wall elasticity (AWE) measured using phased tracking method in patients with type 2 diabetes mellitus (T2DM).Methods: This included T2DM (n= 220, mean age 59 years) without a history stroke or coronary artery disease. AWE, carotid intima-media thickness (IMT), max-IMT flow-mediated vasodilation (FMD) were measured. classified according number risk factors,...