Fredrik Håkonsholm

ORCID: 0000-0002-6248-1810
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About
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Research Areas
  • Antibiotic Resistance in Bacteria
  • Vibrio bacteria research studies
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Microbial infections and disease research
  • Bacteriophages and microbial interactions
  • Antibiotics Pharmacokinetics and Efficacy
  • Parasitic Infections and Diagnostics
  • Genomics and Phylogenetic Studies
  • Bacterial biofilms and quorum sensing
  • Chromium effects and bioremediation
  • Antibiotic Use and Resistance
  • Aquaculture disease management and microbiota
  • Gut microbiota and health

Norwegian Institute of Marine Research
2020-2023

UiT The Arctic University of Norway
2020-2023

Abstract A total of 116 Vibrio isolates comprising V. alginolyticus ( n = 53), metschnikovii 38), anguillarum 21) , antiquarius 2), and fujianensis 2) were obtained from seawater, fish, or bivalve molluscs temperate Oceanic Polar area around Norway. Antibiotic sensitivity testing revealed resistance reduced susceptibility to ampicillin (74%), oxolinic acid (33%), imipenem (21%), aztreonam (19%), tobramycin (17%). Whole‐genome sequence analysis eighteen drug‐resistant the presence genes like...

10.1002/mbo3.1093 article EN cc-by MicrobiologyOpen 2020-06-17

Klebsiella spp. are a major cause of both nosocomial and community acquired infections, with K. pneumoniae being responsible for most human infections. Although present in variety environments, their distribution the sea associated antibiotic resistance is largely unknown. In order to examine prevalence related species marine environment, we sampled 476 batches bivalve molluscs collected along Norwegian coast. From these samples, (n = 78), oxytoca 41), variicola 33), aerogenes 1), Raoultella...

10.3390/microorganisms8121909 article EN cc-by Microorganisms 2020-11-30

Klebsiella pneumoniae (Kp) can cause hospital- and community acquired infections. Although, Kp is widespread in the environment, very little known about genetic diversity pathogenicity of from marine environment. The aim our study was to understand diversity, resistome pathogenic potential 87 isolates Norwegian using whole-genome sequencing. We identified 50 sequence types, including globally disseminated types associated with multidrug resistance or hypervirulence. Ten carried...

10.1016/j.ijheh.2022.113967 article EN cc-by International Journal of Hygiene and Environmental Health 2022-04-07

This work aims to generate the data needed set epidemiological cut-off values for minimum inhibitory concentration (MIC) and disc-diffusion zone measurements of Vibrio anguillarum. A total 261 unique isolates were tested, applying standard methods specifying incubation at 28°C 24-28 h. Aggregated MIC distributions a 247 determined in 9 laboratories 11 agents. Data aggregations disc 10 agents analysed contained between 157 218 observations made by 4 7 laboratories. Acceptable ranges quality...

10.3354/dao03745 article EN cc-by Diseases of Aquatic Organisms 2023-07-06

Klebsiella pneumoniae is an opportunistic pathogen frequently associated with antibiotic resistance and present in a wide range of environments, including marine habitats. However, little known about the development, persistence, spread such environments. This study aimed to obtain complete genome sequences antibiotic-resistant K. isolated from bivalves order determine genetic context antibiotic- heavy metal genes these isolates. Five isolates, which four also carried genes, were selected...

10.1002/mbo3.1368 article EN cc-by MicrobiologyOpen 2023-07-19

We report 579 hybrid genome assemblies (568 complete) of Klebsiella pneumoniae species complex isolates from human, animal and marine sources in Norway collected 2001-2020, belonging to six phylogroups including K. (n=493) variicola (n=69) 364 unique sequence types.

10.1590/scielopreprints.9670 preprint EN SciELO (SciELO Preprints) 2024-09-05

Members of the Klebsiella pneumoniae species complex (KpSC) are opportunistic pathogens that cause severe and difficult-to-treat infections. KpSC common in non-human niches, but clinical relevance these populations is disputed. Utilising 3,255 whole-genome sequenced isolates from human, animal marine sources collected during 2001-2020 Norway, we showed different niches were distinct overlapping. Notably, human infection greatest connectivity with each other, followed by carriage, pigs,...

10.1101/2024.09.11.612360 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2024-09-11
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