A5010566741- Genetics, Aging, and Longevity in Model Organisms
- Heat shock proteins research
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Spaceflight effects on biology
- ATP Synthase and ATPases Research
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Dietary Effects on Health
- thermodynamics and calorimetric analyses
- Biochemical effects in animals
Semmelweis University
2011-2024
Lysosome-related organelles (LROs) play diverse roles and their dysfunction causes immunodeficiency. However, primordial functions remain unclear. Here, we report that C. elegans LROs (gut granules) promote organismal defenses against various stresses. We find toxic benzaldehyde exposure induces LRO autofluorescence, stimulates the expression of LRO-specific genes enhances transport capacity as well increases tolerance to benzaldehyde, heat oxidative stresses, while these responses are...
The FOXO transcription factor family is a conserved regulator of longevity and the downstream target insulin/insulin-like signaling. In Caenorhabditis elegans, ortholog DAF-16A D/F isoforms extend lifespan in daf-2 insulin-like receptor mutants. Here we identify DAF-21/Hsp90 chaperone as regulator. We find that reducing DAF-21 capacity by daf-21(RNAi) initiated either at beginning or end larval development shortens wild-type lifespan. daf-21 knockdown employed from also decreases mutant...
Increased oxidative stress is associated with various diseases and aging, while adaptation to heat an important determinant of survival contributes longevity. However, the impact on resistance remains largely unclear. Aim: In this study we investigated how impinges responses. Results: We report that hydrogen-peroxide (H2O2) pretreatment inhibits both acquired thermotolerance heat-induced Hsp70 expression in mammalian cells, as well nematode Caenorhabditis elegans, via RNA interference....
Sirtuin 1 (SIRT1) othologs are ubiquitous NAD⁺-dependent deacetylases that act as nutrient sensors and modulate metabolism stress responses in diverse organisms. Both mammalian SIRT1 Caenorhabditis elegans SIR-2.1 have been implicated dietary restriction, longevity, healthspan. Hsp90 is an evolutionarily conserved molecular chaperone stabilizes a plethora of signaling 'client' proteins regulates fundamental biological processes. Here we report required for conformational stabilization...
Abstract Proteostasis maintenance and lipid metabolism are critical for survival promote longevity, however, their coordination is largely unclear. Here we show that the heat shock factor HSF-1 proteostasis state regulates lipolysis in C. elegans . We find response to starvation, sirtuin 1 ortholog SIR-2.1 activates by upregulation of adipose triglyceride lipase ATGL-1. In feeding worms, intestinal represses ATGL-1 expression via microRNA system. starving suspends a miR-53- mediated...