A5068092617- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Cancer Genomics and Diagnostics
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Cancer, Hypoxia, and Metabolism
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Thyroid Disorders and Treatments
- 3D Printing in Biomedical Research
- Spinal Fractures and Fixation Techniques
- Head and Neck Surgical Oncology
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Sympathectomy and Hyperhidrosis Treatments
- Cancer Cells and Metastasis
- Hereditary Neurological Disorders
- Amino Acid Enzymes and Metabolism
- Neurofibromatosis and Schwannoma Cases
Institute of Psychiatry and Neurology
2010-2023
University of Siedlce
2020-2023
The Maria Sklodowska-Curie National Research Institute of Oncology
2009-2011
Polish Academy of Sciences
1998-2004
Centralny Szpital Kliniczny
2002-2003
// Jakub Mieczkowski 1, * , Marta Kocyk 2, Pawel Nauman 3 Konrad Gabrusiewicz 1 Małgorzata Sielska Piotr Przanowski Maleszewska Wenson D. Rajan Dominika Pszczolkowska Tomasz Tykocki Wieslawa Grajkowska 4 Katarzyna Kotulska 5 Marcin Roszkowski 6 Boguslaw Kostkiewicz 7 Bozena Kaminska Laboratory of Molecular Neurobiology, Nencki Institute Experimental Biology, Warsaw, Poland 2 Postgraduate School Medicine, Medical University Department Neurosurgery, Psychiatry and Neurology, Departments...
Microlesion effect (MLE) is a commonly observed phenomenon after electrode insertion into the subthalamic nucleus (STN) for deep brain stimulation (DBS).The aim of this study was to determine presence MLE in early postoperative period and relationship between STN DBS.74 patients with Parkinson's disease were included study. Motor symptoms evaluated preoperatively, within 48 h implantation at 6 months United Disease Rating Scale part III (UPDRS-III). According improvement level MLE, all...
Glioblastomas (GBM) are the most common, primary brain tumors in adults. Despite advances neurosurgery and radio- chemotherapy, median survival of GBM patients is 15 months. Recent large-scale genomic, transcriptomic epigenetic analyses have shown cellular molecular heterogeneity GBMs, which hampers outcomes standard therapies. We established 13 GBM-derived cell cultures from fresh tumor specimens characterized them molecularly using RNA-seq, immunoblotting immunocytochemistry. Evaluation...
Postural instability and gait difficulty (PIGD) are commonly observed in advanced Parkinson's disease. The neuronal mechanism of PIGD is not fully understood. Dysfunction the pedunculopontine nucleus (PPN) might be a possible cause these symptoms. autopsy studies subjects with revealed neurodegenerative process involving mainly PPN cholinergic neurons. participates locomotion processes by initiation, modulation execution stereotyped patterns movement. standard neurosurgical treatment PD...
Deep brain stimulation (DBS) is a method of treatment utilized to control medically refractory epilepsy (RE).Patients with who do not achieve satisfactory seizures pharmacological or surgical resection the epileptic focus and those qualify for surgery could benefit from DBS.The most frequently used stereotactic targets DBS are anterior thalamic nucleus, subthalamic central-medial hippocampus, amygdala cerebellum.The believed be an effective various types among adults adolescents.Side effects...
Gliosarcoma is a very rare brain tumor reported to be variant of glioblastoma (GBM), IDH-wildtype. While differences in molecular and histological features between gliosarcoma GBM were reported, detailed information on the genetic background this lacking. We intend fill knowledge gap by complex analysis somatic mutations, indels, copy number variations, translocations gene expression patterns gliosarcomas. Using next generation sequencing, we determined variations (CNVs) 10 Six tumors have...
Rosette‐forming glioneuronal tumor (RGNT) of the fourth ventricle is a recently described novel type primary brain that was included into current WHO classification CNS tumors. It very rare, slowly growing, mixed neoplasm at cerebellar localization with distinctive morphological pattern. We present an unusual case 20‐year‐old patient RNGT advanced microvascular proliferation. MRI revealed solid‐cystic mass largely involving vermis and left hemisphere compression ventricle. Microscopically,...
Rhabdoid meningioma (RM) is a rare, aggressive variant of classified as WHO Grade III malignancy. RM exhibits striking histological resemblance to other rhabdoid tumors and strong tendency towards local recurrences, CSF dissemination, and/or remote metastasis. The majority reported cases are secondary transformation in recurrent meningiomas. We present two unusual meningiomas diagnosed primary intracranial lesion adults that were associated with extensive necrosis an clinical course. On...
Intracranial aneurysms (IAs) of the posterior circulation (PC) rupture more frequently and their morbidity mortality rates are higher compared to anterior circulation. Morphological parameters such as size ratio (SR), inflow angle parent artery geometry believed contribute significantly in determining IA risk rupture. The aim this study is establish angiography-based morphometric predictors PC rupture.A retrospective analysis 58 patients with was incorporated into study. following...
AIm: To assess the correlation between quality of life (QoL), depressive symptoms and motor signs in patients with Parkinson disease after subthalamic deep brain stimulation (DBS STN).mAterIAl methOds: 74 patients, average age 55.6 ± 7 duration 12.3 years± 3.8, treated l STN DBS for PD were included study.All evaluated (UPDRS III), (PDQ-39) (BDI) at baseline 6, 12, 24-month follow up.All also stratified into three groups depending on UPDRS III improvement (<30%, 30-60%, >60%).results: Scores...
Abstract High‐grade gliomas are aggressive, deadly primary brain tumors. Median survival of patients with glioblastoma (GBM, WHO grade 4) is 14 months and <10% survive 2 years. Despite improved surgical strategies forceful radiotherapy chemotherapy, the prognosis GBM poor did not improve over decades. We performed targeted next‐generation sequencing a custom panel 664 cancer‐ epigenetics‐related genes, searched for somatic germline variants in 180 different grades. Herein, we focus on 135...