A5017605676- Bird parasitology and diseases
- Avian ecology and behavior
- Vector-borne infectious diseases
- Wildlife Ecology and Conservation
- Reproductive tract infections research
- Animal Behavior and Reproduction
- Parasite Biology and Host Interactions
- Species Distribution and Climate Change
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
- Viral Infections and Vectors
- Coccidia and coccidiosis research
- Epigenetics and DNA Methylation
- Plant and animal studies
- T-cell and B-cell Immunology
- Ecology and Vegetation Dynamics Studies
- Genetic diversity and population structure
- Cancer Immunotherapy and Biomarkers
- Crustacean biology and ecology
- Plant and fungal interactions
- Genetic and phenotypic traits in livestock
- Insect symbiosis and bacterial influences
- Hemiptera Insect Studies
- Mosquito-borne diseases and control
- Animal Ecology and Behavior Studies
University of Lincoln
2016-2025
University of Leeds
2010-2025
Keele University
2024-2025
QIMR Berghofer Medical Research Institute
2020-2023
Royal Society for the Protection of Birds
2012-2022
University of Canberra
2016-2022
Cardiff University
2018
University of Sheffield
2018
ACT Government
2016-2017
Wake Forest University
1990
Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic is poorly understood. Lysine-specific demethylase 1 (LSD1) a key histone that alters landscape. Here we explored role of LSD1 in global regulation EMT, cancer stem cells (CSCs), tumour microenvironment, and therapeutic resistance breast cancer. induced pan-genomic gene expression implicated EMT selectively elicits programs CSCs whilst repressing non-CSC programs. phosphorylation at...
DNA metabarcoding is a rapidly growing technique for obtaining detailed dietary information. Current methods herbivory, using single locus, can lack taxonomic resolution some applications. We present novel primers the second internal transcribed spacer of nuclear ribosomal (ITS2) designed studies in Mauritius and UK, which have potential to give unrivalled coverage from short-amplicon barcode. In silico testing used three databases plant ITS2 sequences UK Mauritian floras (native introduced)...
Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in cancer metastases and recurrence. Nuclear LSD1 phosphorylated at serine 111 (nLSD1p) has been shown to be critical for the development of breast stem cells. Here we show that circulating tumor cells isolated from immunotherapy-resistant metastatic melanoma patients express higher levels nLSD1p compared responders, which associated with co-expression stem-like, mesenchymal genes. Targeting selective nLSD1...
SUMMARY Studies incorporating the ecology of clinical and sub-clinical disease in wild populations conservation concern are rare. Here we examine infection by Trichomonas gallinae a declining population free-living European Turtle Doves suggest caseous lesions cause mortality adults nestlings through subsequent starvation and/or suffocation. We found 100% rate T. adult nestling ( n = 25) observed signs three four (28%). Adults with displayed no differences any skeletal measures size but had...
Community science can provide crucial insights into population dynamics and demography. To date, its effectiveness for understanding human-wildlife interactions has not been tested. This is vital designing effective wildlife management plans. We used a case study of an individually marked mute swans Cygnus olor, to test the reliability community scientist data quantifying self-reported interactions. compared 5,251 sightings birds with 317 observations recorded through systematic recording...
Abstract Coinfection of a host by more than 1 parasite is common single infection in wild environments and can have differing impacts, although coinfections relatively rarely been quantified. Host immune responses to coinfection contribute costs but are often harder predict those associated with infection, due the influence within-host parasite–parasite interactions on virulence. To first quantify bird species, then test for immune-related impacts coinfection, we investigated prevalence...
ABSTRACT The grey partridge population has experienced significant declines across Europe, largely due to agricultural intensification and loss of habitat, leading conservation actions such as Red‐listing in the UK hunting bans Greece. genetics Balkan Scottish populations remain unexplored; genetic analyses are essential evaluate impact past introduction efforts on wild populations, breeding between released wild‐living partridges may complicate recovery efforts. In this study, we sample...
An abstract is not available for this content so a preview has been provided. As you have access to content, full PDF via the 'Save PDF' action button.
Capsule Turtle Doves continue to show a strong population decline; territories were more likely be retained in areas with nesting habitat, and suitable foraging habitat. Aim To determine which features of farmland England are important for retaining Dove Methods Fifty-eight grid squares recent records territorial resurveyed, compared those from had been lost. Results detected 48% resurveyed. When correcting the 70% detection rate survey methodology, present 66% surveyed suggesting 34%...
SUMMARY Trichomonas gallinae is an emerging pathogen in wild birds, linked to recent declines finch (Fringillidae) populations across Europe. Globally, the main hosts for this parasite are species of Columbidae (doves and pigeons); here we carry out first investigation into presence incidence four UK, through live sampling wild-caught birds subsequent PCR. We report known UK cases infection 86% European Turtle Doves Streptopelia turtur sampled, along with Eurasian Collared decaocto , 47%...
Abstract Dietary changes linked to the availability of anthropogenic food resources can have complex implications for species and ecosystems, especially when are in decline. Here, we use recently developed primers targeting ITS 2 region plants characterize diet from faecal samples four UK columbids, with particular focus on European turtle dove ( Streptopelia turtur ), a rapidly declining obligate granivore. We examine dietary overlap between (potential competition), associations body...
Neonicotinoids are the largest group of systemic insecticides worldwide and most commonly applied as agricultural seed treatments. However, little is known about extent to which farmland birds exposed these compounds during standard practices. This study uses winter cereal, treated with neonicotinoid clothianidin, a test system examine patterns exposure in typical sowing period. The availability neonicotinoid-treated was recorded post-sowing at 39 fields (25 farms), camera traps were used...
Summary 1. The management of habitat structure can limit access to food and also alter perceived predation risk. Minimising the risk predation, by changing behaviour, may have negative impacts similar itself across a wide range species. Predation influences behaviour adults foraging for altricial young, so that they avoid disclosing location their offspring predators. consequences these behavioural changes are unknown. 2. We investigate whether predator‐induced in provisioning rates upon...
Avian trichomonosis is known as a widespread disease in columbids and passerines, recent findings have highlighted the pathogenic character of some lineages found wild birds. Trichomonosis can affect bird populations including endangered species, has been shown for Mauritian pink pigeons Nesoenas mayeri Mauritius suggested European turtle doves Streptopelia turtur UK. However, caused only by parasite Trichomonas gallinae. Therefore, understanding prevalence distribution both potentially...
Understanding how past climatic oscillations have affected organismic evolution will help predict the impact that current climate change has on living organisms. The European turtle dove, Streptopelia turtur, is a warm-temperature adapted species and long distance migrant uses multiple flyways to move between Europe Africa. Despite being abundant, it categorized as vulnerable because of long-term demographic decline. We studied history population genetic structure dove using genomic data...
Summary Post-fledging survival plays a vital role in the dynamics of bird populations and yet is least-studied avian life-stage. Habitat requirements post-fledging may have important implications for behaviour survival, especially declining landscapes that undergone wide-scale anthropogenic modification, resulting an altered distribution composition habitats. The European Turtle Dove widespread but rapidly species both within UK across Europe. Reduced seed food availability thought to...
Since neonicotinoid insecticides were introduced to the agricultural market, evidence of negative impacts these systemic compounds on non-target species has accumulated. Birds are one largest groups inhabit farmland, but extent exposure in avian communities is poorly understood and very little known about how any may affect wild birds. Here, free-living gamebirds used as a model group measure clothianidin via seed treatment. During typical sowing period winter cereals treated with...
Abstract In vitro, ACE2 translocates to the nucleus induce SARS-CoV-2 replication. Here, using digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters, we show that a specific and selective peptide inhibitor nuclear (NACE2i) inhibits viral replication two days after infection. Moreover, also prevents inflammation macrophage infiltration, increases NK cell infiltration in bronchioles. NACE2i treatment levels active histone mark, H3K27ac, restores host...
Pathogens and parasites can have major impacts on host population dynamics, both through direct mortality via indirect effects. Both types of effect may be stronger in species whose populations are already under pressure. We investigated the potential for blood to impact upon their hosts at immunological, physiological level during non-breeding season using a declining yellowhammers Emberiza citrinella as model. Yellowhammers infected by Haemoproteus spp. showed reduced heterophil lymphocyte...
Interactions between hosts and their resident microbial communities are a fundamental component of fitness for both agents. Though recent research has highlighted the importance interactions animals bacterial communities, comparative evidence fungi is lacking, especially in natural populations. Using data from 49 species, we present novel strong covariation fungal across host phylogeny, indicative recruitment by specific suites microbes. co-occurrence networks, demonstrate marked variation...
SUMMARY Studies of blood parasite infection in nestling birds rarely find a high prevalence infection. This is likely due to combination short periods (limiting the age at which nestlings can be sampled) and long prepatent before gametocytes detected peripheral blood. Here we examine rates from three Columbid species UK. We use this system address two key hypotheses epidemiology avian haemoparasites: first, that open nests have higher infection; second, sampled 14 days old apparent rate than...