A5035263771- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Plant Stress Responses and Tolerance
- Cardiac electrophysiology and arrhythmias
- Connexins and lens biology
- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Photosynthetic Processes and Mechanisms
The University of Tokyo
2020-2023
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed five LRRC8A-E isoforms, are pore-forming components volume-regulated anion channel (VRAC). LRRC8A and at least one other LRRC8 isoforms assemble into heteromers to generate VRAC transport activities. Despite availability structures, structural basis how than contribute functional diversity has remained elusive. Here, we present structure human LRRC8D isoform, which enables permeation organic substrates through...
Abstract In the light reaction of plant photosynthesis, modulation electron transport chain reactions is important to maintain efficiency photosynthesis under a broad range intensities. VCCN1 was recently identified as voltage-gated chloride channel residing in thylakoid membrane, where it plays key role photoreaction tuning avoid generation reactive oxygen species (ROS). Here, we present cryo-EM structures Malus domestica (MdVCCN1) nanodiscs and detergent at 2.7 Å 3.0 resolutions,...