A5040430747- IL-33, ST2, and ILC Pathways
- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Whipple's Disease and Interleukins
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- HIV/AIDS oral health manifestations
- Salivary Gland Disorders and Functions
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
Manchester Academic Health Science Centre
2021-2024
University of Manchester
2021-2024
Centre for Inflammation Research
2021-2022
Th17 cell plasticity is crucial for development of autoinflammatory disease pathology. Periodontitis a prevalent inflammatory where cells mediate key pathological roles, yet whether they exhibit any functional remains unexplored. We found that during periodontitis, gingival IL-17 fate-mapped T still predominantly produce IL-17A, with little diversification cytokine production. However, did occur but in the gingiva draining lymph node. Here, some acquired features Tfh cells, was dependent on...
Abstract Psoriasis is a common chronic inflammatory skin disease with no cure. It driven by the IL-23/IL-17A axis and T H 17 cells but, recently group 3 innate lymphoid (ILC3s) have also been implicated. However, development, factors regulating activity of ILC3s remain incompletely understood. Immune regulatory pathways are particularly important at barrier sites such as skin, gut lung, which exposed to environmental substances microbes. CD200R1 an immune cell surface receptor inhibits...