A5075977655- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Physiological and biochemical adaptations
- Insect and Arachnid Ecology and Behavior
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Plant and animal studies
- Photoreceptor and optogenetics research
- Insect Utilization and Effects
- Animal Behavior and Reproduction
- Diet, Metabolism, and Disease
- Connexins and lens biology
- Plant Molecular Biology Research
- Probiotics and Fermented Foods
- Insect and Pesticide Research
- Marine Invertebrate Physiology and Ecology
- Bacillus and Francisella bacterial research
- Antimicrobial Peptides and Activities
University of British Columbia
2018-2023
Okanagan University College
2023
Centre de Recherches sur la Cognition Animale
2012-2021
Université Toulouse III - Paul Sabatier
2012-2021
ESPCI Paris
2015-2017
Université Paris Sciences et Lettres
2015-2017
Centre National de la Recherche Scientifique
2012-2017
ParisTech
2015
Université de Toulouse
2012
Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple pathways in mammals and insects, suggesting more complex code for taste. Here, we examine coding Drosophila. After creating comprehensive molecular map comprised five discrete neuron classes across the fly labellum, find that four are activated salt: two exhibiting characteristics ‘low salt’ cells, ‘high classes. Behaviorally, low attraction depends...
Sensory cues relevant to a food source, such as odors, can be associated with post-ingestion signals related either energetic value or toxicity. Despite numerous behavioral studies, global understanding of the mechanisms underlying these long delay associations remains out reach. Here, we demonstrate in Drosophila that long-term association between an odor and nutritious sugar depends on delayed signaling energy level. We show at neural circuit level activity two pairs dopaminergic neurons...
Manipulating feeding circuits in freely moving animals is challenging, part because the timing of sensory inputs affected by animal’s behavior. To address this challenge Drosophila, we developed Sip-Triggered Optogenetic Behavior Enclosure (‘STROBE’). The STROBE a closed-looped system for real-time optogenetic activation flies, designed to evoke neural excitation coincident with food contact. We previously demonstrated STROBE’s utility probing valence fly neurons (Jaeger et al., 2018). Here...
ABSTRACT Artificial sweeteners are highly sweet, non-nutritive compounds that have become increasingly popular over recent decades despite research suggesting their consumption has unintended consequences. Specifically, there is evidence some of these chemicals interact with bitter taste receptors, implying likely generate complex chemosensory signals. Here, we report the basic sensory characteristics in Drosophila , a common model system used to study impacts diet, and find all noncaloric...
Satiety-encoding Drosophila neurons detect hemolymph glucose and signal to fructose sensors regulate sugar feeding.
Non-caloric artificial sweeteners (NAS) are widely used in modern human food, raising the question about their health impact. Here we have asked whether NAS consumption is a neutral experience at neural and behavioral level, or if can be interpreted remembered as negative experience. We imaging approaches to demonstrate that Drosophila melanogaster learn non-caloric property of through post-ingestion process. These results show sweet taste predictive an energy value, its absence leads...
Tastes typically evoke innate behavioral responses that can be broadly categorized as acceptance or rejection. However, research in Drosophila melanogaster indicates taste also exhibit plasticity through experience-dependent changes mushroom body circuits. In this study, we develop a novel learning paradigm using closed-loop optogenetics. We find appetitive and aversive memories formed by pairing gustatory stimuli with optogenetic activation of sensory neurons dopaminergic encoding reward...
Abstract We studied the involvement of α8 subunit nicotinic acetylcholine receptors (nAChRs) in olfactory learning and memory Apis mellifera . have previously shown, by injecting different antagonists into bee brain, that pharmacologically subtypes nAChRs are important for honeybee –α‐bungarotoxin‐sensitive necessary consolidation mecamylamine‐sensitive involved retrieval processes. Here, we took advantage genome sequencing development a small interfering RNA (siRNA) tool to focus on role...
Animals use their sensory system to detect cues in external environment, then communicate, process, and integrate these through the nervous order elicit a specific response. Taste is an important cue used by animals explore environment can modulate various aspects of animal behavior physiology. A major ongoing challenge for respond presence variety pathogens environment. However, date, links between response pathogenic threats remain poorly understood. Here we show that Drosophila larvae...
Gametogenesis requires coordinated signaling between germ cells and somatic cells. We previously showed that Gap junction (GJ)-mediated soma-germline communication is essential for fly spermatogenesis. Specifically, the GJ protein Innexin4/Zero population growth (Zpg) necessary germline stem cell maintenance differentiation. It remains unknown how GJ-mediated signals regulate spermatogenesis or whether function of these restricted to earliest stages Here we carried out comprehensive...
Abstract An animal’s sensory percepts are not raw representations of the outside world. Rather, they constructs influenced by many factors including species, past experiences, and internal states. One source perceptual variability that has fascinated researchers for decades is effect losing one modality on performance another 1 . Typically, dysfunction sense been associated with elevated function others, creating a type homeostasis 2 For example, people vision loss have reported to...
ABSTRACT Ingestion of certain sugars leads to activation fructose sensors within the brain flies, which then sustain or terminate feeding behavior depending on internal state. Here, we describe a three-part neural circuit that links satiety with sensing. We show AB-FBl8 neurons Fan-shaped body display oscillatory calcium activity when hemolymph glycemia is high, and these oscillations require synaptic input from SLP-AB projecting protocerebrum asymmetric body. Suppression in this circuit,...
How social interactions influences cognition is a fundamental question, yet rarely addressed at the neurobiological level. It well established that presence of conspecifics affects learning and memory performance, but neural basis for influence context has received little attention. In fruitfly Drosophila melanogaster, improves retrieval long-lasting olfactory memory. Here, we demonstrate this composite involves two independent pathways. One based on expression individual depends α'β' lobes...
Tastes are typically thought to evoke innate appetitive or aversive behaviours, prompting food acceptance rejection. However, research in Drosophila melanogaster indicates that taste responses can be modified through experience-dependent changes mushroom body circuits. In this study, we develop a novel learning paradigm using closed-loop optogenetics. We find and memories formed by pairing gustatory stimuli with optogenetic activation of sensory dopaminergic neurons associated reward...
SUMMARY Tastes are typically thought to evoke innate appetitive or aversive behaviours, prompting food acceptance rejection. However, research in Drosophila melanogaster indicates that taste responses can be modified through experience-dependent changes mushroom body circuits. In this study, we develop a novel learning paradigm using closed-loop optogenetics. We find and memories formed by pairing gustatory stimuli with optogenetic activation of sensory dopaminergic neurons associated reward...
Abstract Manipulating feeding circuits in freely moving animals is challenging, part because the timing of sensory inputs affected by animal’s behavior. To address this challenge Drosophila, we developed Sip-Triggered Optogenetic Behavior Enclosure (“STROBE”). The STROBE a closed-looped system for real-time optogenetic activation flies, designed to evoke neural excitation coincident with food contact. We demonstrate that stimulation sweet neurons drives attraction tasteless food, while...