A5034497571- Pharmaceutical Practices and Patient Outcomes
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Health Systems, Economic Evaluations, Quality of Life
- Stress Responses and Cortisol
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Noise Effects and Management
- Pharmacological Effects and Assays
- Frailty in Older Adults
- Adipose Tissue and Metabolism
- Sleep and related disorders
- Mindfulness and Compassion Interventions
- Genetics and Physical Performance
- Chronic Disease Management Strategies
- Healthcare Systems and Practices
- Health disparities and outcomes
- Acute Ischemic Stroke Management
- Meta-analysis and systematic reviews
- Sleep and Work-Related Fatigue
- Medication Adherence and Compliance
- Lipoproteins and Cardiovascular Health
- Cardiovascular and exercise physiology
- Anesthesia and Sedative Agents
- Dementia and Cognitive Impairment Research
Auckland City Hospital
2025
The University of Sydney
2019-2024
Northern Sydney Local Health District
2024
Royal North Shore Hospital
2019-2022
Keogh Institute for Medical Research
2020-2021
University of Otago
2021
This cross-sectional study of national survey data from US adolescents examines changes in rates reported hearing loss, including associations with sociodemographic characteristics.
Abstract Males and females may respond differently to medications, yet knowledge about sexual dimorphisms in the effects of polypharmacy remains limited, particularly aging. This study aimed assess effect high Drug Burden Index (DBI) treatment compared control on physical function behavior young old, male female mice. We studied whether age sex play a role following they are paralleled by differences serum drug levels. Young (2.5 months) old (21.5 months), C57BL/6 mice were randomized or DBI...
Abstract Functional independence is an important aspect of successful aging and differs with age by sex in humans. Physical performance often declines earlier than other age-associated functional impairments. Rodent models are used to study pharmacological/toxicological effects human therapies. However, physical outcomes mice usually assessed for short periods, limited information on the influence sex. Here, we investigated how affected murine over 23 hours continuous observation. Young (3...
Aging, polypharmacy (concurrent use of ≥ 5 medications), and functional impairment are global healthcare challenges. However, knowledge the age/sex-specific effects is limited, particularly on daily physical activities. Using continuous monitoring, we demonstrated how with high Drug Burden Index (DBI-cumulative anticholinergic/sedative exposure) affected behaviors over 23 h in male/female, young/old mice. For comparison, also evaluated different drug regimens (polypharmacy/monotherapy)...
Abstract Background Ageing, sex and polypharmacy affect physical function. Objectives This mouse study investigates how ageing, interact grip strength, balance beam wire hang, correlating comparing the different test results between within subgroups. Methods Young (2.5 months) old (21.5 C57BL/6 J male female mice ( n = 10–6/group) were assessed for function at baseline on hang with three trials of 60 s (WH60s) one trial 300 (WH300s). Mice randomised to control or diet containing a high Drug...
Abstract Background/Importance Stroke and dementia are important causes of death in the United States may be interrelated as competing risks for mortality. No previous studies have simultaneously compared age‐ sex‐specific mortality trends between stroke subtypes at a population level. Insights gained from this study can help identify high‐risk populations inform healthcare service requirements managing States. Objectives To examine nationwide by age group sex. Design Population‐based...
Abstract Aging and multimorbidity are associated with inflammation. Polypharmacy is common in older people multimorbidity. Given the potential for interactions between polypharmacy inflammation, relationship inflammation were studied adults healthy aging mice. A cross-sectional analysis of data from 5-year wave Concord Health Ageing Men Project, a population-based study community-dwelling men aged ≥70 years. Serum concentrations 27 cytokines measured using multiplex immunoassay. Associations...
To examine nationwide trends in delirium mortality Australia and the United States between 2006 2016.Delirium data for Australian populations were obtained from World Health Organization Mortality Database. assessed using joinpoint regression.Age-adjusted increased by 16.35%/year 4.04%/year States, respectively. Average annual age-adjusted rate (per 1 000 population) was 2.90 Australia, 1.06 States. Death rates with age. consistently higher men than women, but of increase greater women.Our...
Hospital inpatients experience substantial sleep problems that have been linked with worse health outcomes, poor quality of life and the post-hospital syndrome. However, little is known about assessing issues in older hospitalised patients.To conduct an in-depth investigation on adults' challenges methods assessment.Cross-sectional observational study.Public hospital inpatient unit.Long-stay adults.Data were collected using validated questionnaires, actigraphy devices qualitative interviews....