The greening of analytical methods has gained interest in the quantitative analysis field to reduce environmental impact and improve safety health conditions for analysts. Nirmatrelvir plus ritonavir is a new FDA approved co-packaged medication developed treatment COVID-19. aim this research was develop green fitted HPLC method using pre experimental computational testing different stationary phases as well selecting mobile phase regarding chemistry principles. Computational study designed...

Favipiravir and remdesivir have been included in the COVID-19 treatment guidelines panel of several countries. The main objective current work is to develop first validated green spectrophotometric methods for determination favipiravir spiked human plasma. UV absorption spectra shown some overlap, making simultaneous difficult. Due considerable two ratio manipulating methods, namely, difference derivative spectra, enabled their pure forms were derived by dividing each drug suitable spectrum...

Abstract Quantitative analysis of pharmaceutical compounds up to Nano gram levels is highly recommended introduce feasible and sensitive tool for determination the in biological samples. Nirmatrelvir plus ritonavir was recently approved US, UK Europe as a new co-packaged dosage form treatment COVID-19. The objective this work develop more TLC method based on using β-cyclodextrin chiral selector additive mobile phase simultaneous nirmatrelvir pure form, formulation spiked human plasma....

ABSTRACT The proposed study uses a special procedure to verify that an analyte assessment operation is sustainable and environmentally friendly. When the targeted molecule (alogliptin drug, ALT) lacks chromophoric or fluorogenic groups, it cannot be analyzed without marking structural amendment. obeyed phenomenon (marking process) could achieved via fluorescence probing using tagging agents. An innovative reagent pair consisting of trioxosulfate ion o ‐Phthaldialdehyde (OPD) used in...

The environmentally friendly design of analytical methods is gaining interest in pharmaceutical analysis to reduce hazardous environmental impacts and improve safety health conditions for analysts. adaptation integration chemometrics the development strongly recommended hope promising benefits. Favipiravir remdesivir have been included COVID-19 treatment guidelines panel several countries. main objective this work develop green, tuned spectrophotometric based on chemometric models...

Promising inhibitory activities of the parasite multiplication were obtained upon evaluation in vivo antimalarial new pyrazolylpyrazoline derivatives against Plasmodium berghei infected mice. Further 5b and 6a chloroquine-resistant strain (RKL9) P. falciparum showed higher potency than chloroquine. In vitro antileishmanial activity testing Leishmania aethiopica promastigote amastigote forms indicated that 5b, 7b possessed promising compared to miltefosine amphotericin B deoxycholate....

Bacterial resistance is spreading in an alarming manner, outpacing the rate of development new antibacterial agents and surging need for effective alternatives. Prenylated flavonoids are a promising class natural antibiotics with reported activity against wide range resistant pathogens. Here, large library (1718 structures) was virtually screened potential candidates inhibiting B-subunit gyrase (Gyr-B). Twenty-eight candidates, predominated by prenylated flavonoids, appeared as hits. Six...

Nigella sativa oil, commonly known as black seed oil (BSO), is a well-known Mediterranean food, and its consumption associated with beneficial effects on human health. A large number of BSO's therapeutic properties attributed to pharmacologically active compound, thymoquinone (TQ), which inhibits cell proliferation induces apoptosis by targeting several epigenetic players, including the ubiquitin-like, containing plant homeodomain (PHD) an interesting new gene, RING finger domains 1 (UHRF1),...

Abstract A computationally-assisted and green spectrophotometric method has been developed for the determination of fostemsavir, a recently FDA-approved drug used in combination with antiretroviral drugs to treat multidrug-resistant HIV-1 infection. The was using computational studies solvent selection based on chemistry principles. density functional theory employed identify bromophenol blue as preferred acid dye efficient extraction fostemsavir. process involved careful evaluation ranking...

Ritonavir was recently combined with nirmatrelvir in a new approved co-packaged medication form for the treatment of COVID-19. Quantitative analysis based on fluorescence spectroscopy measurement extensively used sensitive determination compounds exhibited unique features.The main objective this work to develop higher cost effective spectrofluorometric method selective ritonavir presence pure form, pharmaceutical tablet as well spiked human plasma.Ritonavir found exhibit native emission at...

Nigella sativa oil [NSO] was enriched with biosynthesized silver nanoparticles [NP] by simple, cost-effective, and less time-consuming "Green Chemistry" protocol. This combination [NSO/NP], on blending PVA, produced transparent foldable hydrogel film. The structure, morphology, hydrophilicity thermal stability of film confirmed the incorporation inorganic NP in organic PVA matrix. FTIR spectrum nanocomposite revealed good interactions between matrix, NSO. SEM NSO exhibited lipidic cloud-like...

Abstract Nanocomposite films have been prepared from chitosan, cinnamaldehyde, Nigella sativa or blackseed oil, and silver nanoparticles (NPs) biosynthesized in Azadirachta indica neem leaves’ extract. The methodology involved simple blending of components through “green chemistry” route. obtained were soft foldable. morphology by scanning electron microscopy confirmed the inclusion NPs films. Microbial penetration study demonstrated that offered good resistance to secondary bacterial...

The mixture of hyoscine N-butyl bromide (HBB) and ketoprofen (KTP) is commonly used for the handling abdominal spasms pain relief. There are two challenges that restrict simultaneous assessment HBB KTP in biological fluids pharmaceuticals. first issue difficulty elution second one presence as a racemic all pharmaceutical formulations, which obscures its appearance single peak. An ultrasensitive highly efficient liquid chromatography-mass/mass spectrometric (LC-MS/MS) method designed...

Zein has been used in several pharmaceutical applications because of its unique composition.It is an amphiphilic molecule that biodegradable, biocompatible, and adhesive, matrix-forming, film-coating properties, making it a promising excipient.Zein-based formulations have investigated tabletcoating, nanoparticulate delivery systems, controlled-release formulations.However, to date, very few studies performed on the inclusion zein solid dispersion enhance drug dissolution.This study aimed...

It has always been crucial to have enough water available for survival and growth; hence it is necessary purify polluted reuse. In this study, contaminated cleansed by the adsorption of three dyes Methylene blue (MB), Congo Red (CR), Bromocersol Green (BCG), as well two heavy metals, chromium (VI) zinc (II) using a low cost adsorbents like activated carbon gotten from treated sheep remnants barely husks. H3PO4 acid modified were used in tests, which involved six different parameters (pH,...

A GC-MS analytical method, for the estimation of a vasoconstrictive drug combination naphazoline nitrate and ephedrine hydrochloride, allergic rhinitis treatment, in presence photo-absorptive anti-bacterial additive (methylparaben) impurity (1-naphthaleneacetic acid), is offered concerning cutting-edge trend analysis. Environment, cost, time factors are considered mainly establishment proposed method. The mixture analyzed on highly polar GC stationary phase (5% Phenyl Methyl) Silox. two ions...