A5001650468- Osteoarthritis Treatment and Mechanisms
- Force Microscopy Techniques and Applications
- Polymer Surface Interaction Studies
- Mechanical and Optical Resonators
- Cellular Mechanics and Interactions
- Lower Extremity Biomechanics and Pathologies
- Advanced Cellulose Research Studies
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
- Molecular Junctions and Nanostructures
- Proteoglycans and glycosaminoglycans research
- Collagen: Extraction and Characterization
- Adhesion, Friction, and Surface Interactions
- Cultural Heritage Materials Analysis
- Lipid Membrane Structure and Behavior
- Bone health and osteoporosis research
- Blood properties and coagulation
- Cell Adhesion Molecules Research
- Hydrogels: synthesis, properties, applications
- Catalysis and Oxidation Reactions
- Aerogels and thermal insulation
- Advanced Polymer Synthesis and Characterization
- Edible Oils Quality and Analysis
- Process Optimization and Integration
- Angiogenesis and VEGF in Cancer
Central South University of Forestry and Technology
2018-2024
Central South University
2018-2024
Southern University of Science and Technology
2016-2024
Cell Technology (China)
2024
Materials Science & Engineering
2019
Southwest Jiaotong University
2012-2016
Wuhan University
2016
Titanium (Ti) is now widely used as implant material due to its excellent mechanical properties and superior biocompatibilities, while inert bioactivities might lead insufficient osseointegration, limit performance in dental applications.We introduced a robust simple approach of modifying titanium surfaces with polysaccharide complexes. samples were subjected hydrothermal treatment create uniform porous structure on the surface, followed by coating bioinspired self-assembly polydopamine...
We study the single-chain elasticities of three kinds neutral polymers with a carbon-carbon (C-C) backbone by atomic force microscopy-based single-molecule spectroscopy in nonpolar solvent (octane), aiming at measuring inherent chain elasticity this very important class polymers. The finding that all octane are virtually identical entire region implies side chains have no detectable effects on elasticity. By utilizing from quantum mechanics calculations, freely rotating model can provide...
Poly(N-isopropyl-acrylamide) (PNIPAM) is a paradigm thermally sensitive polymer, which has lower critical solution temperature (LCST) of ∼32 °C in water. Herein by AFM-based single molecule force spectroscopy (SMFS), we measured the chain elasticity PNIPAM across LCST Below LCST, curves obtained at different temperatures have no remarkable difference; while above an unexpected dependent observed, mainly middle regime. We found that 35 turning point variation: from 31 to °C, parts drop...
A composite hydrogel with tunable mechanical properties has been fabricated and characterized in this study.
The single-chain mechanics of two similar thermosensitive polymers, poly(N,N-diethylacrylamide) (PDEAM) and poly(N-isopropylacrylamide) (PNIPAM), have been studied by atomic force microscopy-based single-molecule spectroscopy (SMFS). In a typical nonpolar organic solvent, octane, both the polymers show same inherent elasticity, although they different substitutional groups. However, presents large differences in water. energies needed for rearrangement bound water during elongation at room...
Abstract Collagen, the dominating material in extracellular matrix, provides strength, elasticity and mechanical stability to organisms. The property of collagen is mainly dominated by its surrounding environments. However, variation origin mechanics fibril under different concentrations calcium ions (χ Ca ) remains unknown. By using atomic force microscopy based nanoindentation, structure individual type II were first investigated χ this study. results demonstrate that both structural...
This study was designed to explore the potential therapeutic effects of Mg-based metal organic frameworks (MOFs) in osteoarthritis (OA) and broaden application field MOFs. Mg/HCOOH-MOF introduced characterized by using SEM, XRD, TGA, FTIR. ICP-MS results proved that is stable various physiological media can maintain release Mg2+ ions for a long time. In vitro experiments were carried out evaluate its attenuating OA. successfully synthesized, MTT assays showed it biocompatible promote cell...
Abstract Diabetes is one of the most prevalent diseases worldwide. The tissue regeneration diabetes patients known to be rather tricky as result vascular dysfunction, and this leads various clinical complications including diabetic foot ulcers. endothelial cells, which compactly line inner surface blood vessels, are responsible for growth maintenance vessels play an essential role in regeneration. Although mechanical properties cells generally regulated by physiological/pathological...
Extracellular calcium ion concentration levels increase in human osteoarthritic (OA) joints and contribute to OA pathogenesis. Given the fact that is a mechanical problem, effect of extracellular level ([Ca2+]) on behavior primary chondrocytes remains be elucidated. Here, we measured elastic modulus cell–ECM adhesion forces with atomic force microscopy (AFM) at different levels. With [Ca2+] increasing from normal baseline level, showed trend an subsequent decrease [Ca2+], reaching 2.75 mM....
Radical polymerization from a single initiator molecule in microenvironment is nearly ideal system which bimolecular termination, solution concentration, and viscosity changes could be neglected. In this study, we provide two facile methods of preparing polymers via atom-transfer radical (ATRP) under single-initiator conditions: tether initiators on planar substrates at superlow density through mixed self-assembled monolayers (SAMs) encapsulated microfluidic droplets. The molecular weight...
Abstract Chondrocytes, the resident cells of articular cartilage, play a vital role in tissue maintenance and regeneration. Recent studies have highlighted chondrocyte senescence as key contributor to cartilage dysfunction. In this study, we investigated influence substrate stiffness on using polydimethylsiloxane (PDMS) substrates with varying ratios (1:5, 1:20, 1:60). After culturing chondrocytes these substrates, found that softer (1:60) significantly reduced senescence, evidenced by...
As a potential anticancer agent, azurin has attracted extensive attraction among chemists, physicists, and material scientists. Its structural unfolding/folding information been partially understood, but some detailed information, such as the difference in unfolding processes between apo-azurin holo-azurin, mechanical stability, role of copper cluster its not addressed adequately, especially at single-molecule level. Here, we employed AFM-based force spectroscopy to investigate process apo...