A5081403812- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- SARS-CoV-2 and COVID-19 Research
- Ethics in Clinical Research
- Statistical Methods in Clinical Trials
- Pharmaceutical Economics and Policy
- Birth, Development, and Health
- Gynecological conditions and treatments
- Pharmaceutical studies and practices
- Zoonotic diseases and public health
- Pharmaceutical and Antibiotic Environmental Impacts
- Clinical practice guidelines implementation
- Infant Health and Development
- Thyroid Disorders and Treatments
- Nutritional Studies and Diet
- Vaccine Coverage and Hesitancy
- Animal Vocal Communication and Behavior
- Health and Medical Research Impacts
- Language and cultural evolution
- Health, Environment, Cognitive Aging
- Genetic Associations and Epidemiology
- Hypothalamic control of reproductive hormones
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Breastfeeding Practices and Influences
University of Amsterdam
2020-2025
Amsterdam University Medical Centers
2020-2025
Emma Kinderziekenhuis
2021-2024
Vrije Universiteit Amsterdam
2022-2024
GGD Amsterdam
2024
Durham University
2019-2023
London School of Hygiene & Tropical Medicine
2020-2023
Technion – Israel Institute of Technology
2019-2023
Faculty of Public Health
2023
University College London
2020-2022
Within the first year of distribution vaccines against COVID-19, high-income countries (HICs) have achieved vaccination rates 75-80%, whilst low-income (LICs) vaccinated <10%. This disparity in access has been one greatest failures international cooperation during SARS-CoV-2 pandemic. Global COVID-19 vaccine inequity affects us all, with ongoing risk new variants emerging until global herd immunity is strengthened. The current model based on financial competition for limited supplies,...
The Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19, Vaxzevira or Covishield) builds on two decades of research and development (R&D) into chimpanzee adenovirus-vectored (ChAdOx) technology at the University Oxford. This study aimed to approximate funding for R&D ChAdOx assess transparency reporting mechanisms.
Abstract The forms of many species’ vocal signals are shaped by their functions 1–15 . In humans, a salient context signaling is infant care, as human infants altricial 16, 17 Humans often alter vocalizations to produce “parentese”, speech and song produced for that differ acoustically from ordinary 18–35 in fashions have been proposed support parent-infant communication language learning 36–39 ; modulate affect 33, 40–45 and/or coordinate communicative interactions with 46–48 These theories...
Cultures around the world are converging as populations become more connected. On one hand this increased connectedness can promote recombination of existing cultural practices to generate new ones, but on other it may lead replacement traditional and global WEIRDing. Here we examine process causes changes in traits concerning wild plant knowledge Mbendjele BaYaka hunter-gatherers from Congo. Our results show that who were born town reported knowing using fewer plants than forest camps....
Abstract Objectives The Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19 or Vaxzevira) builds on nearly two decades of research and development (R&D) into Chimpanzee adenovirus-vectored (ChAdOx) technology at the University Oxford. This study aims to approximate funding for R&D ChAdOx vaccine, assess transparency reporting mechanisms. Design We conducted a scoping review publication history analysis principal investigators reconstruct technology. matched award numbers with...
Abstract Background Several drugs are being repurposed for the treatment of coronavirus disease 2019 (COVID-19) pandemic based on in vitro or early clinical findings. As these used varied regimens and dosages, it is important to enable synthesis existing safety data from trials. However, availability information limited by a lack timely reporting overall trial results public registries through academic publication. We aimed analyse evidence gap this conducting rapid review posting...
Coronavirus disease 2019 (COVID-19) mortality and morbidity have been shown to increase with deprivation impact non-White ethnicities more severely. Despite the extra risk Black, Asian Minority Ethnicity (BAME) groups face in pandemic, our current medical research system seems prioritise innovation aimed at people of European descent. We found significant difficulties assessing baseline demographics clinical trials for COVID-19 vaccines, displaying a lack transparency reporting. Further, we...
Research funders can reduce research waste and publication bias by requiring their grantees to register report clinical trials.
Over the past century autoimmune disease incidence has increased rapidly in (post-) industrialised, affluent societies, suggesting that changes ecology and lifestyle are driving this development. Epidemiological studies show (i) 80% of patients female, (ii) diseases co-occur more often women, (iii) some is increasing faster women than men. The female preponderance autoimmunity most pronounced between puberty menopause, diverging sex hormone levels during reproductive years implicated Using...
Ethnographers frequently allude to alcoholism and related harms in Indigenous hunter-gatherer communities, but very few studies have quantified patterns of alcohol consumption or its health social impacts. We present a case study the Mbendjele BaYaka, Congolese population undergoing socioeconomic transition. 83 adults answered questions about their frequency quantity consumption, underwent biometric measurements reported whether they were currently experiencing cough diarrhoea; 56...
Universities' decisions during technology transfer may affect affordability, accessibility, and availability of COVID-19 health technologies downstream. We investigated measures taken by the top 35 publicly funded UK universities to ensure global equitable access between January end October 2020. sent Freedom Of Information (FOI) requests analysed universities' websites, (i) assess institutional strategies on patenting licensing COVID-19-related technologies, (ii) identify all licensed or...
Public investment, through both research grants and university funding, plays a crucial role in the development (R&D) of novel health technologies, including diagnostics, therapies, vaccines, to address coronavirus disease 2019 (COVID-19) pandemic. Using example remdesivir, one most promising COVID-19 treatments, this paper traces back public contributions different stages innovation process. Applying Risk-Reward Nexus framework R&D we analyse risk-taking reward inequities biomedical system....
January 2019, the House of Commons' Science and Technology Committee sent letters to UK universities admonishing them achieve compliance with results reporting requirements for Clinical Trials Investigative Medicinal Products by summer 2019. This study documents changes in clinical trial policies Product performance 20 major following that intervention.
Abstract It has long been suggested that environmental exposures (i.e., the exposome) play a dominant role in shaping trajectories of human aging and premature mortality. Here we aimed to quantify contribution exposome genome We conducted an exposome-wide analysis UK Biobank (n=492,567) systematically identify associated with mortality while accounting for exposure correlation mismeasurement. found is major determinant irrespective genetic disease risk via distinct biological multimorbidity...
Objective To assess to what extent the clinical trial policies of largest public and philanthropic funders research in United States meet WHO best practices registration reporting. Methods Public trials USA with >US$50 million annual spend were selected. The assessed using an 11-item scoring tool based on Joint Statement benchmarks. These 11 items fell into 4 categories, namely: registration, academic publication, monitoring sanctions. An additional item captured whether how referred...
### Summary box #### What is already known? #### are the new findings? #### do findings imply? Universities intend to create knowledge that serves needs of public, yet this does not always happen in practice. By engaging inequitable technology transfer practices, such as exclusive licensing a novel health private company or spin-off, universities enable downstream formation pricing monopolies limit affordable access technologies.1 2 The WHO defines technologies ‘the application organized...
Abstract Background Adrenarche involves maturation of the hypothalamic‐pituitary‐adrenal axis and increased production dehydroepiandrosterone its sulfate ester, dehydroepiandrosterone‐sulfate (DHEA‐S). It occurs at ages 6 to 8 in industrialized populations, marking transition from childhood juvenility cognitive development middle childhood. Studies subsistence level populations indicate a later age (8‐9) for adrenarche, but only two such studies currently exist comparison. Aims To...
Background: Infection prevention and control (IPC) is recognised as essential to addressing the emergence spread of antimicrobial resistance (AMR) in human health, food production environment. How best address this through a One Health perspective remains challenge. This systematic review addresses gap by identifying synthesising evidence from interventions designed improve water, hygiene, sanitation (WASH), biosecurity animal agriculture people that live and/or work with animals. aimed...
Background Early-life exposures during gestation may permanently alter thyroid physiology and health in adulthood. We investigated whether exposure to the Dutch Famine (1944-1945) late, mid, or early influences function (i.e., incidence of disease, autoantibodies, stimulating hormone (TSH), free thyroxine (FT4) levels) specifically assessed potential effects famine differed for men women. Methods This study includes 910 women born as term singletons Wilhelmina Gasthuis Amsterdam,...
Abstract Study question How does conception <6 months after hysterosalpingography (HSG) with iodinated contrast media affect the neurodevelopment of offspring compared to naturally-conceived peers at a school-age? Summary answer Children conceived HSG perform lower on intelligence tests and information processing attention control peers. What is known already Tubal patency in subfertile women commonly assessed using (HSG), but potential risks exposure high iodine content used remains...