Unlike vancomycin trough concentrations, data on the utility of pharmacokinetic (PK) parameters, namely, area under concentration-time curve from 0 to 24 h (AUC0-24), in predicting acute kidney injury (AKI) are limited. Our aim was investigate this relationship patients receiving therapy for methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B). A single-center retrospective observational cohort study involving 127 consecutive MRSA-B conducted examine incidence AKI (defined as...

Broad-range 16S rRNA PCR can be used for the detection and identification of bacteria from clinical specimens in patients whom there is a high suspicion infection cultures are negative. The aims this study were (1) to compare results with microbiological culture results, (2) assess utility regard antimicrobial therapy, (3) yield different types specimen perform cost analysis test.A retrospective was performed on which had over 3 years (2012-2015). Standard appropriate media, as per...

Rapidly growing mycobacterial skin and soft tissue infections are known to complicate cosmetic surgical procedures. Treatment consists of more surgery prolonged antibiotic therapy guided by drug susceptibility testing. Paradoxical reactions occurring during can further treatment non-tuberculous infections. We report a case post liposuction Mycobacterium abscessus site infection in returned medical tourist occurrence paradox treatment.

Nephrotoxicity due to drugs especially beta lactams and cephalosporins has been well recognised. Cefepime is a fourth-generation cephalosporin that widely prescribed with few severe adverse reactions reported. Although cefepime induced neurotoxicity frequently reported, there yet no reported case of acute interstitial nephritis caused by this drug. We report biopsy proven kidney injury associated use for treatment mastoiditis temporal bone osteomyelitis.A 62-year-old Caucasian female...

Antimicrobial stewardship (AMS) interventions largely target inpatient antimicrobial prescribing. Literature on appropriateness of antimicrobials prescribed at the interface between hospital and community is minimal. This study was designed to assess discharge evaluate impact AMS interventions. Patients with medications processed by pharmacy were identified using a computerized medication tracker over four week period. The assessed independently for choice, dose, frequency duration. Data...

Listeria monocytogenes causes gastroenteritis, meningitis and bacteraemia in immunocompromised, pregnant patients, the elderly as well immunocompetent patients. Focal infections with this organism are uncommon, especially sporadic (non-outbreak) setting, require high index of suspicion challenging to diagnose. We present 3 cases presenting focal our hospitals, all which first reported from Australia. Three unrelated unique caused by presented. 1) A 73 year old Caucasian lady on...

Staphylococcus aureus is a common cause of staphylococcal food poisoning in Australia with several outbreaks associated foods prepared by commercial caterers. Laboratory testing on cases gastrointestinal illness caused enterotoxin-producing S. not routinely done as this condition self-limiting. Hence such may go undetected.A retrospective cohort study was conducted among group tourists who were hospitalized Sydney shortly after flying from Queensland. The had consumed restaurant the Gold...

Bacteraemia is associated with high morbidity and mortality, delayed antibiotic treatment poorer outcomes. Early identification challenging, but clinically important. Multiple scoring systems have been developed to identify individuals in the broader categories of sepsis. We designed this study assess performance existing pathways-CEC SEPSIS KILLS pathway (an Australian sepsis care package), quick sequential organ failure score (qSOFA), systemic inflammatory response syndrome (SIRS) Shapiro...

Fungal peritonitis is a serious complication of peritoneal dialysis (PD) therapy with the majority patients ceasing PD permanently. The aims this study were to identify risk factors and clinical associations that may discriminate between fungal from bacterial peritonitis.We retrospectively identified episodes 2001-2010 in at Liverpool Westmead Hospitals (Australia). cases matched 1:2 ratio each institution's registry, occurring closest time episode. Patient demographic, outcome data obtained...

Introduction: Community and healthcare associated infections caused by multi-drug resistant gram negative organisms (MDR GN) represent a worldwide threat. Nucleic Acid Detection tests are becoming more common for their detection; however they can be expensive requiring specialised equipment local expertise. This study was done to evaluate the utility of commercial multiplex tandem (MT) PCR detection MDR GN. Methods: The on stored laboratory GN isolates from sterile non-sterile specimens...

Abstract Differentiating between urinary tract infection and asymptomatic bacteriuria can be a challenge in older adults. It difficult to identify patients who have atypical symptoms make diagnosis of infection. In the absence classic positive urine cultures, there is often unnecessary prescription antibiotic therapy. Asymptomatic persist people evaluation other signs like abdominal pain frequency confused or cognitively impaired patients. This review describes epidemiology risk factors for...

The introduction of an antimicrobial stewardship (AMS) program is associated with a change in prescribing behavior. A proposed mechanism for this by impacting the etiquette described qualitative studies. This study sought to detect attitudes 12 months after AMS and gauge utility various interventions. Surveys were distributed doctors two regional Australian hospitals on convenience basis 6 before, after, AMS. Agreement 20 statements describing (cultural, behavioral knowledge) towards was...

There has been a progressive rise in the incidence of blood stream infections (BSI) caused by multidrug-resistant Gram-negative organisms (MDR GN), which cause increased morbidity and mortality. For this reason, recent studies have focused on risk factors acquisition carbapenemase-producing Enterobacteriaceae extended-spectrum beta-lactamase producers. However, there is limited data for BSI AmpC-producing (AmpC EC), especially low prevalence settings such as Australia. This study was...

Introduction: Extended spectrum beta-lactamases (ESBL) have been increasing worldwide and are associated with increased rates of treatment failure, morbidity, healthcare costs mortality.This study was performed to evaluate the risk factors for mortality in ESBL blood stream infections. Methods:A descriptive retrospective observational case performed.Data collected from patient medical records laboratory information system.Phenotypic resistance testing multiplex PCR assay done.Standard...

Antimicrobial resistance (AMR) remains a major public health threat and the exploration of interventions which may reduce inappropriate antimicrobial use are particular interest. An Antibiotic Hardstop (AH) was included within eMeds system introduced to Central Coast Local Health District (CCLHD) in 2018. The function allows prescribers set predetermined time at antibiotic orders would cease. By default, prescribed length 5 days with view encourage review existing use.Records adult...