A5032175423- Liver Disease Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Radiology practices and education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Photoacoustic and Ultrasonic Imaging
- Medical Imaging Techniques and Applications
- Ultrasound and Cavitation Phenomena
- Peroxisome Proliferator-Activated Receptors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cholesterol and Lipid Metabolism
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Medical Imaging and Analysis
- Venous Thromboembolism Diagnosis and Management
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- MRI in cancer diagnosis
- Microbial Inactivation Methods
- Characterization and Applications of Magnetic Nanoparticles
- Liver physiology and pathology
- Digital Radiography and Breast Imaging
Stanford University
2020-2024
Stanford Medicine
2020-2024
University of California, San Diego
2014-2019
UC San Diego Health System
2018
University of California System
2017
Boston University
2008-2014
Tulane University
2001
Brown University
2001
Hasbro Children's Hospital
2001
The cAMP-elevating A(2b) adenosine receptor (A(2b)AR) controls inflammation via its expression in bone marrow cells.Atherosclerosis induced by a high-fat diet apolipoprotein E-deficient mice was more pronounced the absence of A(2b)AR. Bone transplantation experiments indicated that A(2b)AR cell signals alone were not sufficient to elicit this effect. Intriguingly, liver wild-type vastly augmented diet, raising possibility upregulation is functional significance. genetic ablation led elevated...
In this paper, we describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol–ene cross-linking, core PFC emulsion remains in liquid form even exceeding their boiling points. Critically, formulation permits vaporization rarefactional pressures relevant clinical ultrasound.
We developed a direct method of formulating ultrasound-activatable low boiling point perfluorocarbon nanodroplets with striking characteristics and stability.
Acute deep vein thrombosis (DVT) is the formation of a blood clot in veins body that can lead to fatal pulmonary embolism. DVT difficult distinguish from chronic by ultrasound (US), imaging modality choice, and therefore treated aggressively with anticoagulants, which internal bleeding. Here we demonstrate conjugating perfluorobutane-filled (PFB-filled) microbubbles (MBs) thrombin-sensitive activatable cell-penetrating peptides (ACPPs) could development contrast agents detect acute US...
This case series evaluates changes in numeric pain scores, opioid use, and other measures before, during, 30 days after computed tomography–guided percutaneous cryoneurolysis patients with rib injury.
Background: Osteochondral autologous transplantation surgery (OATS) has been advocated for treatment of osteochondritis dissecans (OCD) the capitellum in adolescents. However, little information is available regarding optimal knee harvest site to match contour and cartilage thickness recipient elbow lesion. Purpose: To characterize capitellar anatomic structure adolescents with without OCD compare these measurements normal adolescent knees identify osteochondral graft harvest. Study Design:...
Background Apolipoprotein E (apoE) is a major protein of the lipoprotein transport system that plays important roles in lipid homeostasis and protection from atherosclerosis. ApoE characterized by structural plasticity thermodynamic instability can undergo significant rearrangements as part its biological function. Mutations 136–150 region N-terminal domain apoE, reduce low density (LDL) receptor binding capacity have been linked with disorders, such type III hyperlipoproteinemia (HLP)...
To determine whether (a) stem cells loaded with DNA-carrying microbubbles (MBs) can be transfected in vivo, (b) the remain alive to express gene, and (c) gene expression is sufficiently robust detected vivo.The study was approved by Institutional Animal Care Use Committee. Cationic MBs were prepared, characterized, pLuciferase green fluorescent protein (GFP) plasmid. Loading confirmed SYBR Gold staining (Life Technologies, Carlsbad, Calif). C17.2 MBs. Two hundred thousand suspended 20 μL...
INTRODUCTION. We have studied the functions of truncated apoE4 forms in vitro and vivo order to identify domains required for biogenesis apoE-containing high-density lipoprotein (HDL). RESULTS. found that apoE4-185, -202, -229, or -259 could promote ATP-binding cassette transporter A1 (ABCA1)-dependent cholesterol efflux vitro, although less efficiently than Full-length apoE4, had diminished capacity activate lecithin acyltransferase (LCAT). Formation HDL was assessed by various methods...
We have used adenovirus-mediated gene transfer in apolipoprotein (apo)E−/− mice to elucidate the molecular etiology of a dominant form type III hyperlipoproteinemia (HLP) caused by R142C substitution apoE4. It was found that low doses adenovirus expressing apoE4 cleared cholesterol, whereas comparable apoE4[R142C] greatly increased plasma triglyceride, and apoE levels, accumulation VLDL/IDL/LDL region, promoted formation discoidal HDL. Co-expression with lecithin cholesterol acyltransferase...
The K146N/R147W substitutions in apoE3 were described patients with a dominant form of type III hyperlipoproteinemia. effects these mutations on the vivo functions apoE studied by adenovirus-mediated gene transfer different mouse models. Expression apoE3[K146N/R147W] mutant apoE-deficient (apoE(-/-)) or apoA-I-deficient (apoA-I(-/-))×apoE(-/-) mice exacerbated hypercholesterolemia and increased plasma triglyceride levels. In apoE(-/-) mice, displaced apoA-I from VLDL/LDL/HDL region caused...
Abscesses, pockets of fluid caused by infections in the human body, are typically treated hospitals draining through a catheter. However, viscous and heterogeneous nature often leads to prolonged treatment duration or even drainage failure. Furthermore, current practice relies only on qualitative observations viscosity for catheter size selection, with little quantitative data guide this parameter. In work, we introduce compact magnetic stress rheometer platform examine rheological response...
Catheter-based embolization has become a widely adopted minimally-invasive treatment for broad range of applications. However, assessment endpoints requires x-ray fluoroscopic monitoring, exposing patients and physicians performing procedures to harmful ionizing radiation. Moreover, fluoroscopy is low sensitivity, subjective, may not reflect the actual physiology blood flow reduction, thus providing little oversight procedure. Inspired by observation that dielectric properties differ from...
Abstract Objective The purpose of this study was to describe the safety and efficacy percutaneous drain placement for postoperative fluid collections in breast. Methods A retrospective review conducted patient characteristics, intervention data, clinical outcomes 43 adult patients who underwent at a tertiary care hospital over 13-year period ending February 28, 2023. Results Most treated with were secondary ipsilateral breast surgery (92%, 44/48), most commonly reduction (23%, 10/44)...