A5045356731- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Gut microbiota and health
- Thermal Regulation in Medicine
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Muscle and Compartmental Disorders
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Infectious Diseases and Tuberculosis
- COVID-19 and healthcare impacts
- Tracheal and airway disorders
Instituto Nacional de Enfermedades Respiratorias
2010-2025
Mexican Social Security Institute
2022
Departamento de Epidemiología
2020
Introduction Some patients with COVID-19 pneumonia present systemic disease involving multiple systems. There is limited information about the clinical characteristics and events leading to acute kidney injury (AKI). We described factors associated development of AKI explored relation mortality in Mexican population severe COVID-19. Methods retrospectively reviewed medical records individuals caused by SARS-CoV-2 hospitalized at largest third-level reference institution for care Mexico...
A high proportion of critically ill patients with COVID-19 develop acute kidney injury (AKI) and die. The early recognition subclinical AKI could contribute to prevention. Therefore, this study was aimed at exploring the role urinary biomarkers NGAL [TIMP-2] × [IGFBP7] for detection in population. This prospective, longitudinal cohort included without entry. Urine samples were collected on admission critical care areas determination concentrations. demographic information, comorbidities,...
Abstract Background Hemophagocytic lymphohistiocytosis (HLH) or commonly known as hemophagocytic syndrome, is a rare and serious disease triggered by myriad of stimuli. HLH characterized an uncontrolled cytokine production, persistent lymphocyte macrophage activation which results in hemophagocytosis. Since people living with human immunodeficiency virus (PLHIV) have increased risk coinfections, gaining great relevance the clinical field it worsens patient's prognosis.Figure 1.Epstein-Barr...
Abstract Background Damage due to respiratory viruses increases the risk of bacterial and fungal coinfections superinfections. High rates invasive aspergillosis are seen in severe influenza COVID‐19. This report describes CAPA cases diagnosed during first wave biggest reference centre for COVID‐19 Mexico. Objectives To describe clinical, microbiological radiological characteristics patients with pulmonary associated critical COVID‐19, as well variables mortality. Methods retrospective study...
In order to discriminate general from aetiology-specific risk factors for immune reconstitution inflammatory syndrome (IRIS), we followed up, during six months, 99 patients with advanced HIV infection commencing antiretroviral therapy (ART) without active opportunistic infections or evident inflammation. IRIS predictors were determined by univariate analysis using clinical data 76 ART-responding either completing follow-up developing IRIS, and multivariate of inflammation, disease...
Around 20-30% of HIV-infected individuals (HIV+) on successful antiretroviral therapy (ART) fail to normalize their CD4 T-cell counts. Various factors could contribute the lack immune reconstitution, one them being thymic insufficiency. We aimed explore associations between recent emigrants (RTEs) and recovery.ART-naive HIV+ who started ART with advanced AIDS were selected. Good versus poor reconstitution was defined by gains above or below 100 T cells/μl. The follow-up period 6...
HIV-1 infection is characterized by a massive depletion of mucosal CD4 T cells that triggers cascade events ultimately linking gut microbial dysbiosis to disease progression and pathogenesis. The association between HIV the enteric virome composition less characterized, although viruses are an essential component ecosystem. Here, we performed cross-sectional analysis fecal viral (eukaryotic bacteriophages) bacterial microbiome in people with (PWH) HIV-negative individuals. To gain further...
In hospitalized COVID-19 patients, disease progression leading to acute kidney injury (AKI) may be driven by immune dysregulation. We explored the role of urinary cytokines and their relationship with stress biomarkers in patients before after development AKI. Of 51 54.9% developed The principal component analysis indicated that subclinical AKI, epidermal growth factor (EGF) interferon (IFN)-α were associated a lower risk while interleukin-12 (IL-12) macrophage inflammatory protein (MIP)-1β...
Double-negative (DN) T cells represent a small and phenotypically heterogeneous population that display regulatory functions. In HIV infection, DN are decreased in peripheral blood have been negatively associated with cell activation. This study was aimed at describing the dynamics phenotypic characteristics of people living (PLHIV) before after antiretroviral therapy (ART) initiation. We included 41 newly diagnosed, ART-naive individuals advanced who were followed up for 6 months ART The...
Abstract Background A considerable portion of the HIV pandemic is composed people under antiretroviral therapy, many whom get a late diagnosis. Patients starting therapy (ART) at very advanced stage disease attain low recovery CD4 T cells. Factors associated with poor are incompletely described. This study aimed finding variables cell in late-presenting patients. Methods We studied cohort + patients initiating ART basal counts. defined immune as net increase circulating counts after one year...
ABSTRACT Introduction Some patients with COVID-19 pneumonia present systemic disease involving multiple systems. There is limited information about the clinical characteristics and events leading to acute kidney injury (AKI). We described factors associated development of AKI explored relation mortality in Mexican population severe COVID-19. Methods retrospectively reviewed medical records individuals caused by SARS-CoV-2 hospitalized at largest third-level reference institution for care...
Background and aim: Small intestine study is a challenge in the field of clinical research. However, capsule endoscopy safe minimally invasive alternative. During COVID-19 pandemic, this endoscopic procedure acquires added value. Although SARS-CoV-2 has mainly respiratory manifestations, gastrointestinal symptoms are observed 30% cases. ACE-2 used by to infect cells highly expressed brush border enterocytes. This enzyme transports essential amino acids small regulates intestinal inflammation...
Abstract Background: A high proportion of critically ill patients with COVID-19 develop acute kidney injury (AKI) and die. Early recognition subclinical AKI could contribute to prevention. Therefore, this study was aimed at exploring the role urinary biomarkers NGAL [TIMP-2]•[IGFBP7] for early detection in population. Methods: This prospective, longitudinal cohort included without entry. Urine samples were collected on admission critical care areas determination concentrations. Demographic...