A5010645107- Autophagy in Disease and Therapy
- Vascular Malformations Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Mosquito-borne diseases and control
HUN-REN Szegedi Biológiai Kutatóközpont
2023
Hungarian Research Network
2022-2023
Institute of Genetics
2023
Research Network (United States)
2022
University of Lausanne
2022
Glial engulfment of neuron-derived debris after trauma, during development, and in neurodegenerative diseases supports nervous system functions. However, mechanisms governing the efficiency degradation glia have remained largely unexplored. Here we show that LC3-associated phagocytosis (LAP), an pathway assisted by certain autophagy factors, promotes glial phagosome maturation Drosophila wing nerve. A LAP-specific subset autophagy-related genes is required for axon clearance, encoding...
Abstract Glial engulfment of dead neurons and neurites after trauma, during development in neurodegenerative diseases plays a crucial role nervous system maintenance. Axon debris generated traumatic injury is cleared by phagocytic glia via Draper receptor signalling Drosophila. However, mechanisms governing the efficiency axon phagocytosis degradation have remained largely unexplored. Here we show that glial LC3-associated (LAP), an pathway assisted certain components macroautophagy...