A5058277015- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Cellular transport and secretion
- Signaling Pathways in Disease
- Glycosylation and Glycoproteins Research
- Invertebrate Immune Response Mechanisms
- Studies on Chitinases and Chitosanases
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Electric Power Systems and Control
- Epigenetics and DNA Methylation
- Genetic Neurodegenerative Diseases
- Vascular Malformations Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Advanced Data Processing Techniques
- Vibrio bacteria research studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Lipid metabolism and biosynthesis
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Calcium signaling and nucleotide metabolism
- Retinal Development and Disorders
- Oil Palm Production and Sustainability
- Cybersecurity and Information Systems
Institute of Genetics
2016-2024
HUN-REN Szegedi Biológiai Kutatóközpont
2016-2024
Hungarian Research Network
2022-2023
Research Network (United States)
2022
University of Szeged
2020-2021
Hungarian Academy of Sciences
2016-2019
Eötvös Loránd University
2009-2016
Autophagy is required for the homeostasis of cellular material and proposed to be involved in many aspects health. Defects autophagy pathway have been observed neurodegenerative disorders; however, no genetically-inherited pathogenic mutations any core autophagy-related (ATG) genes reported human patients date. We identified a homozygous missense mutation, changing conserved amino acid, ATG5 two siblings with congenital ataxia, mental retardation, developmental delay. The subjects' cells...
The small GTPase Rab5 promotes recruitment of the Ccz1-Mon1 guanosine exchange complex to endosomes activate Rab7, which facilitates endosome maturation and fusion with lysosomes. How these factors function during autophagy is incompletely understood. Here we show that autophagosomes accumulate due impaired lysosomes upon loss Ccz1-Mon1-Rab7 module in starved Drosophila fat cells. In contrast, generated Rab5-null mutant cells normally fuse starvation response. Consistent that, dispensable...
Glial engulfment of neuron-derived debris after trauma, during development, and in neurodegenerative diseases supports nervous system functions. However, mechanisms governing the efficiency degradation glia have remained largely unexplored. Here we show that LC3-associated phagocytosis (LAP), an pathway assisted by certain autophagy factors, promotes glial phagosome maturation Drosophila wing nerve. A LAP-specific subset autophagy-related genes is required for axon clearance, encoding...
Yeast Atg8 and its homologs are involved in autophagosome biogenesis all eukaryotes. These the most widely used markers for autophagy thanks to association of their lipidated forms with autophagic membranes. The protein family expanded animals plants, Drosophila species having two homologs. In this Brief Report, we use clear-cut genetic analysis melanogaster show that Atg8a is required autophagy, while non-lipidated form essential developmentally programmed larval midgut elimination...
Autophagy is mediated by membrane-bound organelles and it an intrinsic catabolic recycling process of the cell, which very important for health organisms. The biogenesis autophagic membranes still incompletely understood. In vitro studies suggest that Atg2 protein transports lipids presumably from ER to expanding structures. research has focused heavily on proteins little known about lipid composition membranes. Here we describe a method immunopurification structures Drosophila melanogaster...
SQSTM1/p62-type selective macroautophagy/autophagy receptors cross-link poly-ubiquitinated cargo and autophagosomal LC3/Atg8 proteins to deliver them for lysosomal degradation. Consequently, loss of autophagy leads accumulation polyubiquitinated protein aggregates that are also frequently seen in various human diseases, but their physiological relevance is incompletely understood. Here, using a genetically non-redundant Drosophila model, we show specific disruption ubiquitinated concomitant...
Abstract Glial immunity plays a pivotal role in the maintenance of nervous system homeostasis and responses to stress conditions, including neural injuries. In Drosophila melanogaster , transcription factor Stat92E is activated glial cells following central injury, independently canonical JAK/STAT pathway, shape reactivity towards degenerated axons. However, upstream regulatory mechanisms governing activation remain elusive. Here, we reveal selective autophagy-mediated regulation glia by...
Jipa and Juhász preview results from the lab of Tao Wang (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208147) which show a surprising antagonism between two branches unfolded protein response that dictates disease progression in model autosomal dominant retinitis pigmentosa.
Abstract Glial engulfment of dead neurons and neurites after trauma, during development in neurodegenerative diseases plays a crucial role nervous system maintenance. Axon debris generated traumatic injury is cleared by phagocytic glia via Draper receptor signalling Drosophila. However, mechanisms governing the efficiency axon phagocytosis degradation have remained largely unexplored. Here we show that glial LC3-associated (LAP), an pathway assisted certain components macroautophagy...