A5043432009- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Protein Degradation and Inhibitors
- Luminescence and Fluorescent Materials
- Peptidase Inhibition and Analysis
- Molecular Sensors and Ion Detection
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ubiquitin and proteasome pathways
- Melanoma and MAPK Pathways
- Chemical synthesis and alkaloids
- Advanced Polymer Synthesis and Characterization
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Drilling and Well Engineering
- Lipid Membrane Structure and Behavior
- Porphyrin and Phthalocyanine Chemistry
- Multiple Myeloma Research and Treatments
- Click Chemistry and Applications
- PI3K/AKT/mTOR signaling in cancer
- NF-κB Signaling Pathways
- Chemical Synthesis and Reactions
Zhejiang University of Technology
2019-2025
Dana-Farber Cancer Institute
2016-2024
Harvard University
2016-2024
Blueprint Medicines (United States)
2024
University Town of Shenzhen
2011-2023
Peking University
2011-2023
Shenzhen University
2011-2023
Southwest Petroleum University
2014-2021
Materials Science & Engineering
2021
Institut Charles Sadron
2012-2019
Pumping iron: Double-threaded rotaxanes can be linked to coordination units and polymerized in the presence of iron or zinc ions. pH modulation triggers cooperative contractions (or extensions) individual rotaxanes, thus resulting an amplified motion muscle-like supramolecular chains with changes their contour lengths several micrometers (see picture).
Abstract Targeted protein degradation is a promising drug development paradigm. Here we leverage this strategy to develop new class of small molecule antivirals that induce proteasomal viral proteins. Telaprevir, reversible-covalent inhibitor binds the hepatitis C virus (HCV) protease active site conjugated ligands recruit CRL4 CRBN ligase complex, yielding compounds can both inhibit and HCV NS3/4A protease. An optimized degrader, DGY-08-097, potently inhibits in cellular infection model,...
Ensuring long-term wellbore integrity is critical for carbon dioxide geological storage. Ordinary Portland cement (PC) usually used primary cementing and plug operation, set easily corroded by acidic fluids, such as dioxide, in underground high-temperature high-pressure (HTHP) environments, resulting a decrease the mechanical properties an increase permeability. In order to achieve CO2-rich environment This study introduces materials thermosetting vinyl ester resin (TSR), filler composite...
Developing conductive underwater glue for fast sealing and in situ monitoring is critical ocean exploration yet remains a challenge. The fluidity of double‐edged sword that favorable molecule spreading formation interlocking bonding network also leads to leakage ions. Herein, polymeric possessing good conductivity exhibiting rapid, strong, long‐lasting adhesion on diverse substrates at various harsh environments extreme temperatures developed. For molecular design, the nitrogen heterocyclic...
Abstract An acid–base switchable [ c 2]daisy chain rotaxane terminated with two 2,6‐diacetylamino pyridine units has been self‐assembled a bis(uracil) linker. The complementary hydrogen‐bond recognition patterns, together lateral van der Waals aggregations, result in the hierarchical formation of unidimensional supramolecular polymers associated bundles muscle‐like fibers. Microscopic and scattering techniques reveal that mesoscopic structure these depends on extended or contracted states...
Cereblon (CRBN) is an E3 ligase adapter protein that can be reprogrammed by imide-class compounds such as thalidomide, lenalidomide, and pomalidomide to induce the degradation of neo-substrate proteins. In order identify additional small molecule CRBN modulators, we implemented a focused combinatorial library approach where fused imide-based CRBN-binding pharmacophore heterocyclic scaffold, which could further elaborated. We screened for CRBN-dependent antiproliferative activity in multiple...
Abstract Aberrant activation of FGFR signaling occurs in many cancers, and ATP‐competitive inhibitors have received regulatory approval. Despite demonstrating clinical efficacy, these exhibit dose‐limiting toxicity, potentially due to a lack selectivity amongst the family are poorly tolerated. Here, we report discovery characterization DGY‐09‐192, bivalent degrader that couples pan‐FGFR inhibitor BGJ398 CRL2 VHL E3 ligase recruiting ligand, which preferentially induces FGFR1&2...
A novel responsive europium-based luminescence “off–on” gate for the<italic>in situ</italic>detection of H<sub>2</sub>S in water was developed.
Acrylamide copolymers are often used as acidizing diverting and thickening agents for their advantageous thickening, flocculation, adhesion resistance reduction properties. Experimental results indicate that the acid concentration greatly affects properties of acrylamide polymers, which varies from reported by other researchers. Considering theoretical field application value present study, four comparable acrylamide-based polymers were synthesized, macro- micro-changes well related changes...
The paracaspase MALT1 plays an essential role in activated B cell–like diffuse large cell lymphoma (ABC DLBCL) downstream of and TLR pathway genes mutated these tumors. Although is considered a compelling therapeutic target, the development tractable specific protease inhibitors has thus far been elusive. Here, we developed target engagement assay that provides quantitative readout for MALT1-inhibitory effects living cells. This enabled structure-guided medicinal chemistry effort culminating...
Oral defects lead to a series of function disorders, severely threatening the patients' health. Although injectable hydrogels are widely studied in tissue regeneration, their mechanical performance is usually stationary after implant, without further self-adaption toward microenvironment. Herein, an hydrogel with programmed kinetics instant gelation and gradual self-strengthening along outstanding biodegradation ability developed. The fast realized through rapid Schiff base reaction between...
Novel multi-component supramolecular hydrogels with antibacterial and wound-healing-promoting functions were constructed by taking inspiration from the medication practice of Chinese herbs.
This paper describes the first reversible, heat-set organogel based on supramolecular interactions of β-cyclodextrin (β-CD). The gel was prepared by interaction diphenylamine (DPA) with β-CD and lithium chloride in N,N-dimethylformamide (DMF). In this system, DPA could be gelated DMF as temperature increased then dissolved again decreased. microscopic structure gel, β-CDs play a key role formation nanorods microfibers. Some important features were observed. (1) system is multicomponent...
Mini-Muskeln: Doppelt aufgefädelte Rotaxane können in Gegenwart von Zink- oder Eisenionen mit koordinierenden Einheiten verknüpft und polymerisiert werden. pH-Wechsel lösen ein kooperatives Zusammenziehen (oder Dehnen) der einzelnen aus, bei dem sich die Konturlängen muskelähnlichen supramolekularen Ketten um mehrere Mikrometer ändern (siehe Bild). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited...
A family of triarylamine-fullerene conjugates has been synthesized and shown to self-assemble upon light stimulation in chlorinated solvents. This light-induced process primarily involves excitation triarylamine derivatives, which then oxidize stack with their neutral counterparts form charge transfer complexes the p-conducting channels, while fullerenes are consequently enforced coaxial n-conducting columnar arrangements. These supramolecular heterojunctions can be organized over very long...
The σ/π-binding properties of a series Lewis acids was studied using DFT calculations. results led to the identification Zn(II)/In(III) as suitable dual-mode acid for use in promoting cascade cyclization reactions. Based on this finding, we developed three new types induced reactions and have demonstrated utilities each process natural product synthesis. 1 Introduction 2 Dual-Mode Acids 3 Prins/Conia-Ene Cascade Reaction its Applications 4 Diels–Alder/Carbocyclization 4.1 First Generation...
A logic gate based on a bistable [c2] daisy chain rotaxane decorated with lateral triarylamine units is described, giving rise to an INHIBIT function using proton concentration and light as inputs, producing dual color change supramolecular self-assembly outputs.
In this study, a thermo-responsive temporary plugging agent was developed with the property of solution (sol)–gel–sol transition behavior at different temperatures. At low temperature, material is in sol state, while increasing temperature led to stable gel formation, but can transform again upon further heating. This unique characterized by series SEM, FT-IR, XRD, rheology, and viscoelasticity measurements. All scientific results showed noncovalent interactions between components, which...
A substrate-controlled asymmetric Prins/Conia-ene cascade cyclization has been developed with In(OTf)(3) in CH(3)CN from 0 to 70 °C. These conditions afforded very good yields of the 1-oxadecalin product one pot and effectively suppressed racemization almost no enantiomeric excess (ee) loss. This successfully employed for construction highly functionalized unit phomactin an acyclic β-keto ester alkynal as substrates via a one-pot operation (66% yield, single diastereomer). The moiety readily...
The first and protective group-free total synthesis of (±)-yezo'otogirin C has been achieved from 3-methyl-4-prenylcyclohex-2-enone in eight steps with 23% overall yield. tricyclic core was established via a bioinspired oxidative cascade cyclization strategy using Mn(II)/Mn(III) O2, followed by reduction the peroxy-bridged intermediate thiourea refluxing methanol.