A5021507019- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Melanoma and MAPK Pathways
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diet, Metabolism, and Disease
- Gallbladder and Bile Duct Disorders
- Cutaneous Melanoma Detection and Management
- Cancer Research and Treatments
- Healthcare professionals’ stress and burnout
- Advanced Breast Cancer Therapies
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Screening and Detection
- PARP inhibition in cancer therapy
- Protein Degradation and Inhibitors
- Medical Education and Admissions
- Kidney Stones and Urolithiasis Treatments
- Economic and Financial Impacts of Cancer
University Hospitals of Cleveland
2021-2025
Cleveland Heights University Heights Public Library
2024
Case Western Reserve University
2024
University School
2024
University Hospitals Cleveland Medical Center
2023-2024
Case Comprehensive Cancer Center
2023
University at Buffalo, State University of New York
2017
North Shore University Hospital
2012
Abstract Objective To determine the frequency of depression or anxiety preceding a diagnosis pancreatic cancer (PC). Further, to examine association PC‐associated with treatment compliance and survival. Methods 856 patients PC from single institution were identified using International Classification Diseases (ICD) codes. For each case, two non‐cancer age‐ sex‐matched controls included. Dates ICD codes compared date diagnosis. The medical record was queried further explore psychiatric...
Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet emerge, as chemotherapy remains the best available systemic treatment. However, discovery of safe and adjuncts enhance chemotherapeutic efficacy can still improve survival outcomes. We show that a hyperglycemic state substantially enhances conventional single- multi-agent regimens against PDAC. Molecular analyses tumors exposed high glucose levels reveal expression GCLC...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with a five-year overall survival rate of just 13%, and development chemotherapy resistance nearly universal. PDAC cells overexpress wild-type IDH1 that can enable them to overcome metabolic stress, suggesting it could represent therapeutic target in PDAC. Here, we found anti-IDH1 therapy enhanced the efficacy conventional chemotherapeutics. Chemotherapy treatment induced ROS increased TCA cycle activity cells, along induction...
Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic dependency cancer. The enzyme protects cancer cells under stress, including nutrient limited conditions the tumor microenvironment. Specifically, IDH1 generates NADPH to maintain redox homeostasis produces α-ketoglutarate support mitochondrial function through anaplerosis. Herein, role of...
Abstract Background The study determined the proportion of patients with pancreatic adenocarcinoma (PDAC) who had margin-positive disease and no other adverse pathologic findings (APF) using institutional administrative datasets. Methods Patients clinical stage I or II PDAC in National Cancer Database (NCDB 2010–2020) those underwent pancreatectomy at authors’ institution (2010–2021) were identified. Isolated margin positivity (IMP) was defined as a positive surgical APF (negative nodes,...
Melanomas < 0.8 mm in Breslow depth have less than a 5% risk for nodal positivity. Nonetheless, positivity is prognostic this group. Early identification of may improve the outcomes these patients.To determine degree to which ulceration and other high-risk features predict sentinel lymph node (SLN) very thin melanomas.The National Cancer Database was reviewed from 2012 2018 patients with melanoma thickness mm. Data were analysed 7 July 2022 through 25 February 2023. Patients excluded if data...
Abstract Abstract: Background: A ketogenic regimen is high in fat (90%kCal) and low carbohydrates (5% kCal), resulting a state of ketosis[2]. Prior studies suggest that diet shifts carbon utilization cancer cells from one predominantly glycolytic, towards the tricarboxylic acid cycle (TCA) mitochondria[3]. The net effect on growth remains uncertain, but majority literature favor an anti-cancer signal. We hypothesize molecular biochemical insights into how pancreatic adapt to will uncover...
BackgroundWe examined differences in receipt of guideline-compliant care patients with early-onset versus average-onset biliary tract cancers (BTC) localized or metastatic settings. Additionally, we associations between guideline compliance and overall survival (OS), stratified by age onset clinical stage.MethodsPatients BTC [intrahepatic cholangiocarcinoma, gallbladder adenocarcinoma, extrahepatic cholangiocarcinoma] were identified within the National Cancer Database (2010-2018). Early was...
Pancreatic cancer is the third leading cause of death in United States, and while conventional chemotherapy remains standard treatment, responses are poor. Safe alternative therapeutic strategies urgently needed
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) is associated with a 5-year overall survival rate of just 13%, and development chemotherapy resistance nearly universal. PDAC cells overexpress wild-type isocitrate dehydrogenase 1 (IDH1) that can enable them to overcome metabolic stress, suggesting it could represent therapeutic target in PDAC. Here, we found anti-IDH1 therapy enhanced the efficacy conventional chemotherapeutics. Chemotherapy treatment induced reactive...
Abstract Metabolites of tryptophan degradation are known to alter mood. Their effects have only been superficially examined in the context pancreatic cancer. Herein, we study role indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme important conversion kynurenine, a murine model cancer–associated depression. Behavioral tests (open field, forced swim, tail suspension, and elevated plus maze) biochemical assays (LC-MS metabolomics) were used characterize depressive-phenotype tumor-bearing mice...
The complement system which is a critical mediator of innate immunity plays diverse roles in the neuropathogenesis HIV-1 infection such as clearing and promoting productive replication. In development associated neurological disorders (HAND), there may be an imbalance between activation regulation, contribute to neuronal damage consequence infection. It well recognized that opiate abuse exacerbates neuropathology, however, little known about role proteins induced neuromodulation,...
Abstract Background and Aims: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms cancer, with a five-year overall survival rate 12% among all-comers. Current systemic therapeutic options are limited to cytotoxic chemotherapies which have clinical efficacy often associated rapid development drug resistance. We examined mechanistic implications combining anti-wild-type IDH1 therapy conventional chemotherapeutics treat PDAC. Methods: Therapeutic responses were tested in...
Abstract INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy due to the lack of early diagnosis and limited response treatments. Austere nutrient-deprived conditions typically present in PDAC tumor microenvironment (TME) induce chemotherapy resistance. Therefore, novel therapeutic strategies are needed. We have previously demonstrated primary expresses IDH1 which supports pro-survival oxidative phosphorylation (OXPHOS) metabolism, has been successfully...
Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related deaths in the United States. While Poly (ADP-ribose) polymerase (PARP) inhibitors hold promise treating PDAC with Homologous Recombination Deficiency (HRD). However, HRD occurs only 10% cases, leaving 90% intact Proficiency (HRP). Our research highlights key role wild-type isocitrate dehydrogenase 1 (IDH1) maintaining cellular function. We found that inhibiting IDH1 increases DNA damage,...
Abstract Background: A ketogenic diet, with high fat (90% kCal) and low carbohydrate (5% intake, induces ketosis [2], altering cancer cell carbon utilization toward the tricarboxylic acid cycle (TCA) [3]. While overall impact on growth is unclear, most literature suggests an anti-cancer effect. Our hypothesis aims to uncover pancreatic adaptations revealing metabolic vulnerabilities for informed therapeutic strategies. Methods: Mice a or normal diet (control) underwent xenograft observation....
Abstract Introduction: Oncogenic BRAF mutations are present in about 50% of melanoma and clinically targetable by inhibitors such as dabrafenib. While show high rates clinical response, that response is transient resistance inevitably develops. Previously we have demonstrated induce a metabolic shift towards the mitochondrial oxidative phosphorylation. We shown inhibition wild type isocitrate dehydrogenase 1 (wtIDH1), vital anaplerotic anti-ROS enzyme, demonstrates synergy with dabrafenib...