About
Contact & Profiles
A5039977508
Research Areas
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Redox biology and oxidative stress
- Paraquat toxicity studies and treatments
- Free Radicals and Antioxidants
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Insect and Pesticide Research
- ATP Synthase and ATPases Research
- Electrochemical Analysis and Applications
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
Northwestern University
2015-2020
10.1016/j.molcel.2015.12.002
article
EN
publisher-specific-oa
Molecular Cell
2015-12-24
10.1038/s41586-020-2475-6
article
EN
Nature
2020-07-08
10.1038/nchembio.2499
article
EN
Nature Chemical Biology
2017-10-23
Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels to support cells is not fully understood. To address this, we conducted a metabolism-focused CRISPR-Cas9 genetic screen uncovered that loss genes encoding subunits complex I was deleterious in presence mitochondria-targeted antioxidant mito-vitamin E (MVE). Genetic or pharmacologic inhibition...
10.1126/sciadv.abb7272
article
EN
cc-by-nc
Science Advances
2020-11-05
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