A5061220131- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Salivary Gland Tumors Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Soft tissue tumor case studies
- Occupational and environmental lung diseases
- Lymphoma Diagnosis and Treatment
- Heterotopic Ossification and Related Conditions
- Salivary Gland Disorders and Functions
- Meningioma and schwannoma management
- Cutaneous Melanoma Detection and Management
- Enzyme function and inhibition
- Breast Lesions and Carcinomas
- Electromagnetic Fields and Biological Effects
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Melanoma and MAPK Pathways
- Urologic and reproductive health conditions
- Chronic Lymphocytic Leukemia Research
- Multiple and Secondary Primary Cancers
- Parathyroid Disorders and Treatments
- Vascular Tumors and Angiosarcomas
- Uterine Myomas and Treatments
Russian Cancer Research Center NN Blokhin
2020-2024
Ministry of Health of the Russian Federation
2022
All-Russian State Scientific Research Institute for Control, Standardization and Certification of Veterinary Preparations
2015
Chemotherapy of soft tissue sarcomas (STS) is restricted by low chemosensitivity and multiple drug resistance (MDR). The purpose our study was the analysis MDR mechanism in different types STS. We assessed expression ABC-transporters, MVP, YB-1, analyzed their correlation with cancer cells. STS specimens were obtained from 70 patients without metastatic disease (2018–2020). Expression level MDR-associated genes estimated qRT-PCR cytofluorimetry. Mutations ABC-transporter captured exome...
Soft tissue sarcomas (STS) are heterogeneous cancers with more than 100 histological subtypes, different in molecular alterations, which make its personalized therapy very complex. Gold standard of chemotherapy for advanced STS includes combinations Doxorubicin and Ifosfamide or Gemcitabine Docetaxel. Chemotherapy is efficient less 50% patients it followed by a fast development drug resistance. Our study was directed to the search genetic alterations cancer cells associated chemoresistance...
Leptomeningeal metastases are lesions of brain and/or spinal cord sheaths by tumor cells. They occur in 5% patients with solid tumors, although autopsies reveal these much more often (10-20% cases). Leptomengeal an unfavorable prognostic factor. Despite the modern NCCN treatment standards, including intrathecal therapy (ITT), such receive only irradiation entire most cases.
The paper provides a detailed description of rare case rheumatoid arthritis concurrent with Sjogren's syndrome, MALT lymphoma the parotid gland, and multiple myeloma. It presents review literature
The article analyzes the molecular genetic features ofperitoneal mesothelioma in order to identify differential diagnostic signs of disease, factors tumor growth, as well identifying ways improve current treatments.
The article analyzes the modern molecular genetic features pseudomyxoma of peritoneum in order to find a possible source and causes disease, identify factors tumor growth, as well identification ways improve current treatments.
The comparative analysis data of immunocytochemistry and mmunohistochemistry studies mediastinal lymph nodes. Immunocytochemical method is not inferior in their capabilities by immunohistochemistry the differential diagnosis metastatic nodes mediastinum.
Меланома имеет самую высокую мутационную нагрузку среди солидных опухолей. Идентифицировано множество связанных с меланомой соматических и герминальных мутаций в генах, ряд из которых так называемых «драйверных генов», вероятнее всего, включаются опухолевую прогрессию являются основными молекулярной классификации меланомы. В этой части обзора приведен анализ изменений генах KIT, NF1 RAC1, зависимости от источника первичной опухоли. Приводятся последние данные о мутациях CDKN2A, BAP1, TERT,...
Сложности цитологической диагностики фиброэпителиальных опухолей: фиброаденома и филлоидная опухоль Л.М. Родионова, Л.В
Myositis ossificans is a rare disorder, characterized by heterotopic bone formation in muscles or soft tissues which often mistaken for neoplasia. The reasons ossification these may be different. In most cases there previous trauma, but etiology inheritable. Heritable myositis also called Fibrodysplasia Ossificans Progressiva (FOP) associated with mutations the ACVR1 gene and congenital abnormalities, of malformations great toes constant as well wide femur neck. We report case FOP 9-year-old...
Introduction. Metastases of breast cancer are detected in 5 to 48% cases, depending on the biological tumor subtype, which is second most common after lung men. Cytological liquor analysis one “gold standards” for metastatic brain lesion identification, and, among other modern approaches, it can increase CNS metastasis detection. Breast cell identification cerebrospinal fluid a poor prognostic factor. A cytological examination has predictive significance these patients: absence cells be...
Introduction. The identification of predictive factors is a cornerstone task modern oncology. development new targeted drugs determines the need for prediction chemosensitivity each patient to prescribed therapy, in this regard, search biomarkers response therapy actively conducted. study objective investigate relationship between tumor cell resistance and expression levels CA IX (carbonic anhydrase IX) VEGF A (vascular endothelial growth factor А) patient-derived cultures soft tissue...
Neurofibromatosis type I (NF1) is the monogenic inherited syndrome with established variability of clinical manifestations and predisposition to development malignant tumors. Studying NF1 association different types cancers in children necessary understand risk their occurrence prognosis disease as well subsequent studies this predisposition.
 Aim. Analysis data patients benign tumors arisen them.
 Methods. A retrospective analysis 19 from 0 18 years old a tumor, carried out N.N....