Abstract Objective The aim of the study was to analyse relationships between plasma apelin‐36 and apelin‐12 levels, nutritional status, insulin resistance hormonal disturbances, as well adiponectin, leptin resistin concentrations in PCOS women. Study design patients measurements A cross‐sectional involving 87 (48 obese) 67 non‐ women (36 obese). Anthropometric parameters body composition were determined. Serum glucose, androgens, FSH , LH SHBG insulin, apelin‐36, apelin‐12, measured fasting...

Acne vulgaris in women can indicate a systemic disease, such as polycystic ovary syndrome (PCOS), which is associated with hormonal and metabolic disorders. The aim of this study was to investigate the influence disorders on acne PCOS.The included 110 PCOS. Women were divided according their androstenedione concentration: within reference range (n=66) or higher (n=44). All patients between 17-36 years old. graded US FDA scale for five-category global system (acne severity scale). Hirsutism...

Studies show an association between polycystic ovary syndrome (PCOS) and increased incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) in this patient group. Diagnostic tools that can screen relevant groups PCOS' patients for are still being sought. Our study included 242 with PCOS diagnosed on the basis Rotterdam criteria, which we divided according to phenotypes. Using Fibrosis-4 (FIB-4) BAAT (BMI, age, ALT, triglycerides) calculators, conducted screening each...

The study aimed to estimate the cut-off value for homeostatic model assessment insulin resistance (HOMA-IR) discriminating based on sex hormones binding globulin (SHBG) level in women with polycystic ovary syndrome (PCOS).Data from medical records of 854 Caucasian diagnosed PCOS were analyzed. Anthropometric data, fasting plasma glucose, and SHBG levels measured. HOMA-IR was calculated a standard formula. using receiver-operating characteristics.Circulating below normal range (26.1 nmol/L)...

It is suggested that disturbed adipokines release plays a role in PCOS pathogenesis. The aim of this study was to assess plasma levels omentin and adiponectin as well the ratio, markers adipose tissue dysfunction relation hormonal or metabolic changes PCOS.A cross-sectional involved 87 (48 obese) 72 non-PCOS women (41 obese). Anthropometric parameters body composition were determined, serum glucose, hormones, omentin-1 measured.The level similar groups, but, both, significantly lower obese...

Uterine myomas represent one of the most frequently manifested benign tumors in women. They originate from smooth muscle cells myometrium or its blood vessels. Many studies suggest that inflammation and pro-inflammatory factors may play a role carcinogenesis with an involvement transcription factor NF-kappaB which activity can be controlled by various environmental factors, including many cytokines. The aim study was to investigate expression NF-B, interleukin-1β (IL-1β), tumor necrosis...

The aim of the study was to analyse relationship between nutritional status, selected adipokines and plasma anti-Müllerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS).A prospective, cross-sectional study, involving 87 PCOS (48 obese) 67 non-PCOS (36 obese). Anthropometric parameters were measured, body composition determined by bioimpedance method. Fasting serum glucose, androgens, FSH, LH, SHBG, insulin, AMH, apelin-36, adiponectin, leptin omentin-1 measured.Plasma...

Sleep disturbances in women with Polycystic Ovary Syndrome (PCOS) have been reported recent years. The majority of published studies are related to Obstructive Apnea (OSA) while not many researches analyzed any other causes sleep disturbances. A group ninety five were enrolled into the study. assessed using validated questionnaires. On grounds Athens Insomnia Scale (AIS) evaluation a clinically significant insomnia was ascertained 12.6% PCOS, according Severity Index (ISI) 10.5%. Clinically...

Superoxide dismutase (SOD) is a crucial antioxidant enzyme involved in the pathway during both normal cellular metabolism and different pathologic processes. We investigated activity of copper (Cu)-zinc (Zn) SOD1 as well level Cu Zn serum women with polycystic ovary syndrome (PCOS) control group. Moreover, prevalence rs2070424 gene polymorphism course PCOS was evaluated. Significantly lower SOD 1 Cu, concentration found group than without syndrome. Insulin resistance caused further decrease,...

Anovulatory cycles and endometriosis are the main causes of female infertility. The most frequently anovulatory related to polycystic ovary syndrome (PCOS) commonly associated with obesity hormonal disturbances in course obesity. Recently published studies revealed that infertility affects about one six couples during their lifetime is more frequent obese. Obesity also male erectile dysfunction, lower semen quality. Any these above mentioned disorder important risk factor psychological poor...

Objectives: The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status inflammation in PCOS. Material methods: A cross-sectional involving 86 PCOS (47 obese) 72 Non-PCOS women (41 determined anthropometric parameters body composition. Serum glucose, insulin omentin-1, TNF-α, sTNFRs, IL-6 sR-IL6 were measured fasting state. Results: Plasma significantly lower than group both corresponding normal weight obese subgroups. In three analyzed...

We aimed to evaluate the relationship between selected serum sex hormones and lipid profiles in a group of women with polycystic ovary syndrome (PCOS) dividing according four phenotypes, value body mass index (BMI), presence hyperlipidemia. The study included 606 Caucasian women. Lipids were estimated using commercially available procedures during hospitalization 2017. Phenotype PCOS, BMI value, hyperlipidemia significant factors that influenced androgen hormone concentrations, such as total...

Genotoxic assessment of landfill leachate before and after biological treatment was conducted with two human cell lines (Me45 NHDF) Daphnia magna somatic cells. The alkali version comet assay used to examine genotoxicity by DNA strand breaks analysis its repair dynamics. samples were collected from Zabrze landfill, situated in the Upper Silesian Industrial District, Poland. Statistically significant differences (Kruskal-Wallice ANOVA rank model) observed between cells incubated (<mml:math...

In women with chronic kidney disease (CKD) fertility abnormalities occur frequently. Anti-Müllerian hormone (AMH) inhibits excessive recruitment of primordial follicles. The aim the study was to evaluate serum AMH concentration in on hemodialysis and after transplantation (KTx).46 hemodialysed 14 CKD about undergo were enrolled into study. control group consisted 40 healthy women. all subjects determined (in once, KTx immediately before surgery, 3 times transplantation).Serum did not differ...

Decreased synthesis of sex hormone-binding globulin (SHBG) related to hyperinsulinemia is one the disturbances characteristic polycystic ovary syndrome (PCOS). Hyperinsulinemia a compensatory mechanism for liver insulin resistance (IR); thus, SHBG may be considered as surrogate marker IR. Therefore, this study aimed assess prediction IR and impaired fasting glucose (IFG) based on levels in women with PCOS.This analysis included data retrieved from medical records 854 patients PCOS...

Objective The aim of this study was to analyse relationships between plasma fibroblast growth factor 21 (FGF21) levels and nutritional status, metabolic hormonal disturbances in polycystic ovary syndrome (PCOS) women. Design setting A cross-sectional involving 85 PCOS (48 obese) 72 non-PCOS women (41 conducted evaluate the relationship FGF21 PCOS. Methods Anthropometric parameters body composition were determined. In fasting state; serum concentrations glucose, androgens, FSH, LH, SHBG,...