Since the 1990s, there has been a significant increase in number of imaging examinations as well related healthcare expenditure and exposure population to X-rays. This study aimed analyze workload trends radiology during last decade, including impact COVID-19 single university hospital Poland identify possible solutions challenges that could face future. We compared annual amount computed tomography (CT), radiography (X-ray), ultrasound (US) performed between years 2010 2020 analyzed changes...

Self-perception of body size seems to be not always in line with clinical definitions normal weight, overweight and obesity according Word Health Organization classification. The effect self-perception disturbances dissatisfaction may the development eating disorders, such as anorexia nervosa or binge disorder-a major risk factor development. Therefore, study aimed assess separately perception weight status well adults obesity. included 744 (452 women; 35.9 ± 12.4 years; 21 underweight, 326...

Abstract Objective The aim of the study was to analyse relationships between plasma apelin‐36 and apelin‐12 levels, nutritional status, insulin resistance hormonal disturbances, as well adiponectin, leptin resistin concentrations in PCOS women. Study design patients measurements A cross‐sectional involving 87 (48 obese) 67 non‐ women (36 obese). Anthropometric parameters body composition were determined. Serum glucose, androgens, FSH , LH SHBG insulin, apelin‐36, apelin‐12, measured fasting...

An important factor influencing the perception of health‑related quality life (HRQoL) is presence chronic diseases, especially polymorbidity. However, little known about how concurrent diseases influence HRQoL hypertensive patients. The primary aim study was to assess relationship between comorbidities and different aspects in a large unselected cohort patients undergoing treatment for hypertension. A questionnaire‑based conducted by 832 care physicians group 12,525 treated hypertension at...

In March 2020 lockdown due to the COVID-19 pandemic forced Polish Medical Universities implement e-learning. The aim of study was evaluate perception e-learning by students in Poland.

The study aimed to assess the relationship between plasma pentraxin 3 (PTX-3) levels and potential diagnosis of fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) older adults. This was assessed using Fibrosis-4 index (FIB-4), NAFLD score (NFS), Hepamet (HFS). subanalysis included 2,397 adults (aged 60 years older) from population-based PolSenior2 study, all whom had risk factors for steatotic liver disease (MASLD) underwent PTX-3 assessment. participants were divided into...

ABSTRACT Objective There is limited data concerning the effect of untreated subclinical thyroid disorders on mortality in older adults. Therefore, this study aimed to analyze 5‐year overall among participants PolSenior with treated and dysfunction. Design Methods The group consisted 407 (305 hypothyroidism 102 hyperthyroidism) 2776 euthyroid individuals aged 65 years older. Overall risk factors were assessed Cox proportional hazard regression. Additionally, survival analyses performed...

Objective. To study the influence of anti-tumor necrosis factor-α (TNF-α) treatment on echocardiographic measures and concentrations endothelin 1 (ET-1), interleukin 6 (IL-6), amino-terminal fragment pro-brain natriuretic peptide (NT-proBNP) in a cohort 23 female patients with rheumatoid arthritis (RA). Methods. We recruited (mean age 51.3 ± 1.55 yrs) RA resistant to disease-modifying antirheumatic drugs average disease duration 7.1 1.0 years who had been selected start anti-TNF-α antagonist...

The brain-derived neurotrophic factor (BDNF) is one of the candidate genes for schizophrenia. There evidence that val66met polymorphism may be involved in pathophysiology authors genotyped (rs6265) BDNF gene 208 inpatients with paranoid schizophrenia and 254 control subjects a Polish population. was no association between development either men or women. However, an found this age at onset psychopathology Men val/met genotype had earlier onset, val/val predisposed to more severe symptoms,...

To elucidate a genetic predisposition to major depressive disorder, we investigated two polymorphisms (−31T/C and −511C/T) in the interleukin-1beta promoter region patients who suffered from recurrent depression. The aim of current work was compare alleles genotype layout between with depression healthy people. We would like indicate such combination genotypes which corresponds Correlations for analyzed number episodes, points Hamilton Depression Rating Scale, age onset were as well. study...

Numerous reports have brought attention to the potential role of cytokines in schizophrenia. The aim study was determine whether polymorphisms IL-2, IL-6, and TNFα genes are risk factors for development paranoid schizophrenia a Polish population. Promoter IL-6 (rs1800795), (rs1800629), IL-2 (rs2069762) patients (N=115) controls (N=135) were genotyped by PCR-RFLP AS-PCR methods, respectively. Genotype TT allele T polymorphism, genotype AA A polymorphism found be significantly associated with...

Summary Background Fibroblast growth factor 23 ( FGF 23) is a hormone involved in calcium–phosphate homoeostasis. The data of recently published studies suggest that ‐23 may also play role some metabolic processes beyond mineral metabolism, such as insulin resistance or energy aim the study was to attempt relationships between plasma cFGF (C‐terminal) and iFGF (intact) concentrations occurrence obesity, inflammation elderly population. Materials methods analysis included 3115 subjects (1485...

Vitamin D (VD) deficiency is considered an independent risk factor for death due to cardiovascular events including ischemic stroke (IS). We assessed the hypothesis that decreased levels of 25-hydroxyvitamin (25-OH-D) are associated with increased mortality in patients IS. Serum 25-OH-D, intact parathyroid hormone (iPTH), and fibroblast growth 23 (iFGF23) were serum 240 consecutive admitted within 24 hours after onset Mortality data was obtained from local registry office. Only three...

The study aimed to estimate the cut-off value for homeostatic model assessment insulin resistance (HOMA-IR) discriminating based on sex hormones binding globulin (SHBG) level in women with polycystic ovary syndrome (PCOS).Data from medical records of 854 Caucasian diagnosed PCOS were analyzed. Anthropometric data, fasting plasma glucose, and SHBG levels measured. HOMA-IR was calculated a standard formula. using receiver-operating characteristics.Circulating below normal range (26.1 nmol/L)...

It is suggested that disturbed adipokines release plays a role in PCOS pathogenesis. The aim of this study was to assess plasma levels omentin and adiponectin as well the ratio, markers adipose tissue dysfunction relation hormonal or metabolic changes PCOS.A cross-sectional involved 87 (48 obese) 72 non-PCOS women (41 obese). Anthropometric parameters body composition were determined, serum glucose, hormones, omentin-1 measured.The level similar groups, but, both, significantly lower obese...

Symptoms of depression are common in patients diagnosed with benign prostatic hyperplasia (BPH) and usually a reaction to deterioration health, severity lower urinary tract symptoms, erectile dysfunction. The aim this observational study was evaluate the prevalence depressive symptoms BPH factors affecting their occurrence large Polish cohort. Four thousand thirty-five men (4,035) participated survey (age 65 ± 8 years). assessed using Beck inventory, (LUTS) on basis international prostate...

The aim of the study was to analyse relationship between nutritional status, selected adipokines and plasma anti-Müllerian hormone (AMH) levels in women with polycystic ovary syndrome (PCOS).A prospective, cross-sectional study, involving 87 PCOS (48 obese) 67 non-PCOS (36 obese). Anthropometric parameters were measured, body composition determined by bioimpedance method. Fasting serum glucose, androgens, FSH, LH, SHBG, insulin, AMH, apelin-36, adiponectin, leptin omentin-1 measured.Plasma...

Context The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation hormonal changes during menstrual cycle young, healthy, normal-weight women. Methods involved 52 Anthropometric parameters, body composition addition serum FSH, LH, estradiol, progesterone, 17-OH androgens, SHBG insulin concentrations were measured a morning fasting state three times: between days 2–4, 12–14 24–26 cycle....

Objective: An assessment of the feasibility fascia iliaca compartment block (FICB) combined with nonopioid analgesics and patient controlled analgesia (PCA), oxycodone, in perioperative anaesthetic management for elective total hip replacement (THR). Design: A randomised, single-center, open-label study. Setting: single hospital. The study was conducted from October 2018 to May 2019. Participants: In total, 109 patients were scheduled replacement. Interventions: Postoperative FICB 0.375%...

Background: Our study analyzes the frequency and risk factors of hyperuricemia use allopurinol in a representative cohort older Polish adult population. Methods: The analysis was part cross-sectional PolSenior on aging Poland. complete medication data were available 4873 out 4979 community dwelling respondents aged 65 over. Serum uric acid concentrations evaluated 4028 participants (80.9% cohort). Results: Hyperuricemia observed 28.2% women 24.7% men. Ten selected based multivariable LASSO...

Cisplatin is still a widely used anticancer drug characterized by significant nephrotoxicity. Acute kidney injury (AKI), diagnosed based on the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, has limitations, including delayed increase in creatinine. We determined usefulness of neutrophil gelatinase-associated lipocalin (NGAL), molecule-1 (KIM-1), and interleukin-18 (IL-18) diagnosing AKI according to KDIGO criteria patients treated with cisplatin. recruited 21 subjects starting...

Aim The aim of the study was to assess influence number hours daily nursing care for NHPPD in medical departments on missed and correlation between in-hospital mortality. Background Patient mortality can be a consequence as it correlates with nurse–patient ratio. One methods measure is Nursing Hours per Day rating. Methods sample included 44,809 patients including 971 deaths 8 wards. hours, education, percentage patients' classification were evaluated backward stepwise linear regression....