A5102941002- HIV/AIDS drug development and treatment
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Cholesterol and Lipid Metabolism
- Machine Learning in Bioinformatics
- Natural Antidiabetic Agents Studies
Universidade Federal de Alagoas
2022
Barcelona Biomedical Research Park
2020
Abstract Cardiovascular disease (CVD) is a leading cause of death worldwide. Approximately 60% patients treated with low‐density lipoprotein (LDL)‐lowering drug treatments, on‐target plasma cholesterol levels, are still suffering clinical acute ischemic events. Mechanisms, such as LDL aggregation, underlie extracellular and intracellular accumulation in the vasculature. A peptide sequence (P3) receptor‐related protein 1 (LRP1) efficiently protects from sphingomyelinase (SMase‐) phospholipase...
Interest in antiviral plant species has grown exponentially and some have been reported to anti-HIV properties. This research aims perform the bio-guided phytochemical fractionation by antiretroviral activity of Lafoensia pacari stem barks. vitro experimental study involved preparation material, obtention ethanolic extract, fractionation, purification, identification quantification fractions, acid-base extraction, nuclear magnetic resonance, HIV-1 RT inhibition test molecular docking...