A5059784334- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Meat and Animal Product Quality
- Cardiovascular Disease and Adiposity
- Proteins in Food Systems
- Machine Learning in Bioinformatics
- Endoplasmic Reticulum Stress and Disease
- Protein Kinase Regulation and GTPase Signaling
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Calpain Protease Function and Regulation
- Diabetes Treatment and Management
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Spaceflight effects on biology
- Cerebrovascular and Carotid Artery Diseases
- Food composition and properties
Institut d'Investigacions Biomèdiques de Barcelona
2018-2025
Consejo Superior de Investigaciones Científicas
2018-2024
Hospital de Sant Pau
2017-2023
Universitat Autònoma de Barcelona
2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2020
The HDL (high-density lipoprotein)-mediated stimulation of cellular cholesterol efflux initiates macrophage-specific reverse transport (m-RCT), which ends in the fecal excretion macrophage-derived unesterified (UC). Early studies established that LDL (low-density lipoprotein) particles could act as efficient intermediate acceptors cellular-derived UC, thereby preventing saturation and facilitating their capacity. However, capacity to a plasma reservoir its potential impact supporting m-RCT...
Antibodies targeting the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) inhibit interaction between ApoB100 in cholesteryl ester (CE)-enriched lipoproteins and CR9 domain LRP1, preventing intracellular CE accumulation induced by a high-fat high-cholesterol (HFHC) diet cardiomyocytes. This study examines (i) whether HFHC induces cholesterol mitochondria, impacts cardiac bioenergetics, (ii) effectiveness anti-P3 Abs mitigating HFHC-induced mitochondrial alterations. Cardiac tissue was...
Background:The LRP1 (CR9) domain and, in particular, the sequence Gly 1127 -Cys 1140 (P3) plays a critical role binding and internalization of aggregated LDL (agLDL).We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis.Methods: Female New Zealand White (NZW) rabbits were immunized primary injection four reminder doses (R1-R4) IrP (irrelevant peptide) or conjugated carrier.IrP P3-immunized randomly divided into normal group HFD-fed...
18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence.Our aim was to evaluate the performance of soluble low-density lipoprotein receptor-related protein 1 (sLRP1) as an indicator inflammation.A prospective study conducted among adult patients with recent (< 7 days) anterior circulation ischemic at least one atherosclerotic in ipsilateral internal artery. Patients underwent early 15 days from inclusion) 18F-FDG...
Few studies have analyzed the potential of biophysical parameters as markers cardiac remodeling post-myocardial infarction (MI), particularly in human hearts. Fourier transform infrared spectroscopy (FTIR) illustrates overall changes proteins, nucleic acids and lipids a single signature. The aim this work was to define FTIR lipidomic pattern for left ventricular post-MI. A total nine explanted hearts from ischemic cardiomyopathy patients were collected. Samples right ventricle (RV), (LV)...
The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated (aggLDL) internalization mediated by low-density lipoprotein receptor-related protein-1 (LRP1) promoting intracellular cholesteryl ester (CE) accumulation. Additionally, LRP1 plays a key function in the regulation insulin receptor (IR) glucose transporter type 4 (GLUT4) activities. Nevertheless,...
Antibodies against the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) specifically block cholesteryl ester (CE) accumulation in vascular cells. is a key regulator insulin receptor (InsR) trafficking different cell types. The link between CE and response are largely unknown. Here, effects peptide immunization on alterations induced by high-fat diet (HFD) cardiac were evaluated. Irrelevant (IrP)- or peptide-immunized rabbits randomized into groups fed either HFD normal chow. Cardiac lipid...
Left ventricular (LV) remodelling after myocardial infarction (MI) is a crucial determinant of the clinical course heart failure. Matrix metalloproteinase (MMP) activation strongly associated with LV MI. Elucidation plasma membrane receptors related to specific MMPs fundamental for treating adverse cardiac The aim current investigation was explore potential association between low-density lipoprotein receptor-related protein 1 (LRP1) and MMP-9 MMP-2 spatiotemporal expression Real-time PCR...
Our aim was to identify biophysical biomarkers of ventricular remodelling in tachycardia-induced dilated cardiomyopathy (DCM). study includes healthy controls (N = 7) and DCM pigs 10). Molecular analysis showed global myocardial metabolic abnormalities, some them related hibernation failing hearts, supporting the translationality our model cardiac cardiomyopathy. Histological unorganized agglomerated collagen accumulation ventricles a higher percentage fibrosis right (RV) than left (LV)...
Abstract Cardiovascular disease (CVD) is a leading cause of death worldwide. Approximately 60% patients treated with low‐density lipoprotein (LDL)‐lowering drug treatments, on‐target plasma cholesterol levels, are still suffering clinical acute ischemic events. Mechanisms, such as LDL aggregation, underlie extracellular and intracellular accumulation in the vasculature. A peptide sequence (P3) receptor‐related protein 1 (LRP1) efficiently protects from sphingomyelinase (SMase‐) phospholipase...
The accumulation of lipids in cardiomyocytes contributes to cardiac dysfunction. specific blockage cardiomyocyte cholesteryl ester (CE) loading by antibodies (Abs) against the P3 sequence (Gly1127–Cys1140) LRP1 receptor improves insulin sensitivity. impact anti-P3 Abs on high-fat diet (HFD)-induced extracellular matrix (ECM) biophysical alterations was analyzed. Both IrP (without Abs) and P3-immunized rabbits (with were randomized into groups fed either HFD or a standard chow diet. Cardiac...
Low-density lipoprotein receptor-related protein 1 (LRP1) negatively modulates circulating atrial natriuretic peptide (ANP) levels. Both molecules are involved in the regulation of cardiometabolism. To evaluate soluble LRP1 (sLRP1) and ANP levels people with newly diagnosed type 2 diabetes mellitus (T2DM) determine effects metabolic optimization. This single-center longitudinal observational study recruited patients T2DM (n = 29, HbA1c > 8.5%), 12 healthy control, age- sex-matched...
Dyslipidemia, metabolic disorders and/or obesity are postulated as risk factors for pancreatic ductal adenocarcinoma (PDAC). The majority of patients with these alterations have low density lipoproteins (LDLs) increased susceptibility to become aggregated in the extracellular matrix (ECM). LDL aggregation can be efficiently inhibited by low-density lipoprotein receptor-related protein 1 (LRP1)-based peptides. objectives this work were: (i) determine if LDLs affect intracellular cholesteryl...
Patients with familial hypercholesterolemia (FH) exhibit a significant residual cardiovascular risk. A new risk factor is the susceptibility of individual LDL particles to aggregation. This study examined aggregation and its relationship lipid composition biophysical properties in patients FH compared controls. was measured as change particle size, assessed by dynamic light scattering, after exposure sphingomyelinase, which breaks down sphingomyelin phospholipid layer. Dynamic scattering...
Los estudios ultraestructurales en Synechocystis se centran principalmente el ficobilisoma (PBS); sin embargo existen pocos informes sobre efecto del campo magnético a este nivel. El objetivo de la investigación fue examinar los principales efectos fisiológicos, cambios bioquímicos y inducidos por estático (SMF) un rango moderado inducción (β: 35-45 mT), con fin obtener evidencias para explicar estrategia respuesta nivel celular molecular S. aquatilis (cepa local), explorando potencial SMF...
The main constitutive macromolecules of cardio-vascular tissues, essential to the cohesion and resiliency, are also active components which evolve with physiology pathology.Their functionality is connected their internal dynamics over various scales time length, in close correlation water.Vibrational, thermal dielectric techniques, have showed ability characterize synthetic polymers, deserve be adapted study proteins biological tissues.Through some examples, we will show how these techniques...