A5051517748- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Protease and Inhibitor Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Cellular transport and secretion
- Protein Kinase Regulation and GTPase Signaling
- Antioxidant Activity and Oxidative Stress
- Cell Adhesion Molecules Research
- Advanced MRI Techniques and Applications
- Calcium signaling and nucleotide metabolism
- Retinal Development and Disorders
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cardiomyopathy and Myosin Studies
- Nitric Oxide and Endothelin Effects
- Galectins and Cancer Biology
- Growth Hormone and Insulin-like Growth Factors
- Blood properties and coagulation
- Adipose Tissue and Metabolism
- Complement system in diseases
- Proteins in Food Systems
University of California, San Diego
2024-2025
Research Centre in Biological Chemistry of Córdoba
2018-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2023
Universidad Nacional de Córdoba
2016-2023
Macrophages play a pivotal role in the early stages of atherosclerosis development; they excessively accumulate cholesterol cytosol response to modified Low Density Lipoprotein (mLDL). The mLDL are incorporated through scavenger receptors. CD36 is high-affinity cell surface receptor that facilitates binding and uptake long-chain fatty acids into cell. Numerous structurally diverse ligands can initiate signaling responses regulate metabolism, migration, angiogenesis. Nitro-fatty endogenous...
BACKGROUND: Muscle proteins of the obscurin protein family play important roles in sarcomere organization and sarcoplasmic reticulum T-tubule architecture function. However, their precise molecular functions redundancies between members as well involvement cardiac diseases remain to be fully understood. METHODS: To investigate functional Obsc (obscurin) its close homolog Obsl1 (obscurin-like 1) heart, we generated analyzed knockout mice for , Obsc/Obsl1 double knockouts. RESULTS: We show...
Abstract Insulin-like Growth Factor-1 (IGF-1) is involved in the normal development and survival of retinal cells. Low-density lipoprotein Receptor-related Protein-1 (LRP1) plays a key role on regulation several membrane proteins, such as IGF-1 receptor (IGF-1R). In brain astrocytes, LRP1 interact with IGF-1R glucose transporter type 1 (GLUT1), regulating uptake these Although GLUT1 expressed Müller Glial Cells (MGCs), its not clear yet. Here, we investigated whether modulates traffic to...
ABSTRACT Distinct modes of cell migration contribute to diverse types movements. The mesenchymal mode is characterized by a multistep cycle membrane protrusion, the formation focal adhesion, and stabilization at leading edge associated with degradation extracellular matrix (ECM) components regulated proteolysis. Both α 2 ‐Macroglobulin (α M) its receptor, low density lipoprotein receptor‐related protein 1 (LRP1), play important roles in inflammatory processes, controlling activity several...
The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated (aggLDL) internalization mediated by low-density lipoprotein receptor-related protein-1 (LRP1) promoting intracellular cholesteryl ester (CE) accumulation. Additionally, LRP1 plays a key function in the regulation insulin receptor (IR) glucose transporter type 4 (GLUT4) activities. Nevertheless,...
Antibodies against the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) specifically block cholesteryl ester (CE) accumulation in vascular cells. is a key regulator insulin receptor (InsR) trafficking different cell types. The link between CE and response are largely unknown. Here, effects peptide immunization on alterations induced by high-fat diet (HFD) cardiac were evaluated. Irrelevant (IrP)- or peptide-immunized rabbits randomized into groups fed either HFD normal chow. Cardiac lipid...
Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) is expressed in retinal Müller glial cells (MGCs) and regulates intracellular translocation to the plasma membrane (PM) of proteins involved cellular motility activity. Different functions MGCs may be influenced by insulin, including removal extracellular glutamate retina. In present work, we investigated whether insulin promotes LRP1 PM glial-derived cell line MIO-M1 (human cell-derived line). We demonstrated that stored small...
Abstract Activated α 2 -macroglobulin (α M*) and its receptor, low-density lipoprotein receptor-related protein 1 (LRP1), have been linked to proliferative retinal diseases. In Müller glial cells (MGCs), the M*/LRP1 interaction induces cell signaling, migration, extracellular matrix remodeling, processes closely associated with disorders. However, mechanism whereby M* LRP1 participate in aforementioned pathologies remains incompletely elucidated. Here, we investigate whether regulates both...
Cardiovascular disease (CVD) is a multisystemic and multicellular pathology that generally associated with high levels of atherogenic lipoproteins in circulation. These tend to be retained modified, for example, aggregated low-density lipoprotein (aggLDL), the extracellular matrix different tissues, such as vascular wall heart. The uptake aggLDL generates significant increase cholesteryl ester (CE) these tissues. We previously found accumulation CE alterations insulin response Although...
Activated alpha-2 Macroglobulin (α2M*) is specifically recognized by the cluster I/II of LRP1 (Low-density lipoprotein Receptor-related Protein-1). a scaffold protein for insulin receptor involved in insulin-induced glucose transporter type 4 (GLUT4) translocation to plasma membrane and uptake different types cells. Moreover, II plays critical role internalization atherogenic lipoproteins, such as aggregated Low-density Lipoproteins (aggLDL), promoting intracellular cholesteryl ester (CE)...
The accumulation of lipids in cardiomyocytes contributes to cardiac dysfunction. specific blockage cardiomyocyte cholesteryl ester (CE) loading by antibodies (Abs) against the P3 sequence (Gly1127–Cys1140) LRP1 receptor improves insulin sensitivity. impact anti-P3 Abs on high-fat diet (HFD)-induced extracellular matrix (ECM) biophysical alterations was analyzed. Both IrP (without Abs) and P3-immunized rabbits (with were randomized into groups fed either HFD or a standard chow diet. Cardiac...
Subclinical atherosclerosis (SCA) occurs in asymptomatic individuals. Blood peripheral monocytes are involved the development of atherosclerosis. Circulating acquire pro-inflammatory profiles, and they early stages development. Low-density lipoprotein Receptor-related Protein 1 (LRP1) is expressed monocytes, mainly classical intermediate subsets. Although LRP1 highly macrophages vascular smooth muscle cells (VSMCs) atherosclerotic plaque formation, its expression circulating has not been...
Abstract Cardiovascular disease (CVD) is a multisystemic and multicellular pathology that generally associated with high levels of atherogenic lipoproteins in circulation. These tend to be retained modified, for example, aggregated low-density lipoprotein (aggLDL), the extracellular matrix different tissues, such as vascular wall heart. The uptake aggLDL generates significant increase cholesteryl ester (CE) these tissues. We previously found accumulation CE alterations insulin response...