A5052609345- Multiple Myeloma Research and Treatments
- 3D Printing in Biomedical Research
- Liver physiology and pathology
- Dendrimers and Hyperbranched Polymers
- Proteoglycans and glycosaminoglycans research
- Cellular Mechanics and Interactions
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Mathematical Biology Tumor Growth
- Advanced biosensing and bioanalysis techniques
- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Protein Degradation and Inhibitors
- Online and Blended Learning
- E-Learning and Knowledge Management
- Immunotherapy and Immune Responses
- Electrospun Nanofibers in Biomedical Applications
- Education and Critical Thinking Development
- Entrepreneurship Studies and Influences
- Phagocytosis and Immune Regulation
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
Universitat Politècnica de València
2019-2025
Universitat de València
2024-2025
Centro de Investigacion Principe Felipe
2024-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2020-2025
Instituto de Salud Carlos III
2025
Senescent cells are involved in age-related disorders different organs and therapeutic targets for fibrotic chronic pathologies. Immune-modulating agents, able to enhance senescent cell detection elimination by endogenous immune cells, have emerged as pharmacological strategies. We report herein a nanoparticle cell-mediated senolytic therapy designed recruit response specific enzymatic matrix metalloproteinase-3 (MMP-3) activity the senescence-associated secretory phenotype. For this,...
Multiple myeloma (MM) is a hematological malignancy in which the patient's drug resistance one of main clinical problems. As 2D cultures do not recapitulate cellular microenvironment, has key role resistance, there an urgent need for better biomimetic models. Here, novel 3D platform used to model MM. The semi-solid culture consists dynamic suspension microspheres and MM cells, termed as microgel. Microspheres are synthesized with acrylic polymers different sizes, compositions,...
Abstract Melanoma is one of the most common types skin cancer with a bad prognosis and limited treatment options in advanced stages. Immunotherapy has changed landscape oncology. Cancer cells can activate various mechanisms to suppress immune responses, such as immunological checkpoint programmed cell death‐1 (PD‐1)/programmed death‐ligand 1 (PD‐L1), whose blockage reactivates killing melanoma cells. Moreover, exposure inhibitory cytokines transforming growth factor‐beta (TGF‐β) induces T...
The development of three-dimensional environments to mimic the in vivo cellular response is a problem building disease models. This study aimed synthesize and validate support for culturing monoclonal plasma cells (mPCs) as model multiple myeloma. environment biomimetic microgel formed by alginate microspheres produced on microfluidic device whose surface has been functionalized layer-by-layer process with components bone marrow's extracellular matrix, which will interact mPC. As proof...
Bone marrow mechanical conditions play a key role in multiple myeloma cancer. The complex and chemical conditions, as well the interactions with other resident cells, hinder development of effective treatments. Agent-based computational models, capable defining specific for every single cell, can be useful tool to identify tumor microenvironment. In this sense, we have developed novel hybrid 3D agent-based model coupled fluid particle dynamics study cells’ growth. model, which considers...
The mechanical signals received from the multiple myeloma microenvironment play a key role in bone marrow cancer development. However, complexity of cues hinders development novel and effective treatment. As such, agent-based computational models that consider coupled fluid dynamics for every single cell may provide distinct perspectives information to adequately identify specific tumor microenvironment. We have developed 3D model considers particle study growth response stimuli Cell...
Esta comunicación resume parte de los resultados del proyecto Erasmus+ “CRİTİCAL THİNKİNG AS A STEP FORWARD İN VET EDUCATİON: students immersed in high technology teams” en el que han participado empresas base tecnológica, centros superiores investigación y formación profesional europeos. Durante dos años se diseñado estrategias para desarrollar la herramientas pensamiento crítico estudiantes durante prácticas realizadas alta tecnología. Se ha elegido un conjunto reducido capacidades...
Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival this disease tightly related to marrow environment. Proliferation viability nPCs depend on their interaction with stromal extracellular matrix components, which also influences appearance drug resistance. Recapitulating these interactions vitro culture requires 3D environments that incorporate biomolecules interest. In...
VET STUDENTS İNTO TECHNOLOGY COMPANİES: A MICROLEARNING DIGITAL COURSE TO TRAIN CRITICAL THINKING SKILLS
L. Gómez-Estrada1, Pietra2, C. Zoli2, A. Soriano Martínez3, P. Karampelas4, A.M. Almeida5, J.S. Nunes6, J.M. Martínez Ardil7, M.T. Guillot-Ferriols8, S. Clara-Trujillo8, Solano Martínez1, J.L. Gómez Ribelles8 1Ikasia Technologies SL (SPAIN) 2Smallcodes SRL (ITALY) 3IES Politécnico, Cartagena 41st Epalgematiko Lykeio Kato Achaia (GREECE) 5Centro de Física das Universidades do Minho e Porto (CF-UM-UP) (PORTUGAL) 6Somatica, Materials & Solutions 7CIPF Hespérides, 8Universitat Politècnica València