A5035867786- Cannabis and Cannabinoid Research
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Prenatal Substance Exposure Effects
- Functional Brain Connectivity Studies
- Pharmacological Receptor Mechanisms and Effects
- Religion, Spirituality, and Psychology
- Diet, Metabolism, and Disease
- Substance Abuse Treatment and Outcomes
University College London
2019-2022
Mental Health Research UK
2022
King's College London
2020
Abstract Rationale There is growing interest in the therapeutic potential of cannabidiol (CBD) across a range psychiatric disorders. CBD has been found to reduce anxiety during experimentally induced stress anxious individuals and healthy controls. However, mechanisms underlying putative anxiolytic effects are unknown. Objectives We sought investigate behavioural neural single dose vs. placebo on emotion-related measures test cognitive-mechanistic models its anxiety. Methods conducted...
Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the two major constituents of cannabis with contrasting mechanisms action. THC is psychoactive, addiction-promoting, psychotomimetic compound, while CBD may have opposite effects. The brain effects these drugs alone in combination poorly understood. In particular, striatum implicated pathophysiology several psychiatric disorders, but it unclear how influence striato-cortical connectivity.To examine THC, CBD, + on functional connectivity...
Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing evidence that cannabidiol may influence some aspects of processing. However, it unknown whether acutely affects brain underpinning anticipation and feedback. Hypotheses: We predicted would augment activity associated Methods: administered a single 600 mg oral dose matched placebo to 23 healthy participants in double-blind,...
Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are two major constituents of cannabis with contrasting mechanisms action. THC is the psychoactive, addiction-promoting, psychotomimetic compound, while CBD may have somewhat opposite effects. The brain effects these drugs alone in combination poorly understood. In particular striatum implicated pathophysiology several psychiatric disorders, but it unclear how influence striato-cortical connectivity. Across placebo-controlled,...
Background There is growing interest in the therapeutic potential of cannabidiol (CBD) across a range psychiatric disorders. CBD has been found to reduce anxiety during experimentally-induced stress anxious individuals and healthy controls. However, mechanisms underlying putative anxiolytic effects are unknown. We therefore sought investigate behavioural neural single dose vs. placebo on emotion-related measures test cognitive-mechanistic models its anxiety. Methods conducted randomised,...