A5018196996- Cannabis and Cannabinoid Research
- COVID-19 and healthcare impacts
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Trauma and Emergency Care Studies
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- Hip and Femur Fractures
- Sleep and related disorders
- Attention Deficit Hyperactivity Disorder
- Obstructive Sleep Apnea Research
- Neurotransmitter Receptor Influence on Behavior
- Cardiovascular Health and Disease Prevention
- Neuroscience of respiration and sleep
- Neurological and metabolic disorders
- Diagnosis and treatment of tuberculosis
- Diverticular Disease and Complications
- Amoebic Infections and Treatments
- Sleep and Wakefulness Research
- Musculoskeletal Disorders and Rehabilitation
- Forensic Toxicology and Drug Analysis
- Prenatal Substance Exposure Effects
- Psychedelics and Drug Studies
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
National Hospital for Neurology and Neurosurgery
2020-2022
University College London
2018-2022
North Bristol NHS Trust
2021-2022
University of Bristol
2022
Southmead Hospital
2022
University of California, Los Angeles
2022
Stoke Mandeville Hospital
2021
Warneford Hospital
2021
University of Oxford
2021
Lincoln College
2021
What you need to know• Cannabis based products for medicinal use contain cannabinoids derived from the cannabis plant, including ∆ 9 -tetrahydrocannabinol (THC), cannabidiol (CBD), or a combination of THC and CBD.Synthetic typically mimic effects specific such as THC• is constituent that causes "high," whereas CBD not intoxicating at typical doses.THC have contrasting mechanisms action therapeutic indications; carries higher risk adverse events compared with CBD• Rescheduling on 1 November...
Abstract With the rising demand for ketogenic diet therapy in adult epilepsy, there is a need research describing real-life effectiveness, retention, and safety of relevant services. In this 1-year prospective cohort study we present outcomes first 100 referrals modified (MKD) at UK’s largest tertiary-care epilepsy centre, where patients received dietetic review up to twice per week. Of referrals, 42 (31 females, 11 males; mean age 36.8 [SD ± 11.4 years]) commenced MKD, having used 4 (SD 3)...
Background: Cannabidiol (CBD) is being investigated as a potential treatment for several medical indications, many of which are characterised by altered memory processing. However, the mechanisms underlying these effects unclear. Aims: Our primary aim was to investigate how CBD influences cerebral blood flow (CBF) in regions involved secondary determine if on CBF were associated with differences working and episodic task performance. Methods: We used randomised, crossover, double-blind...
Background: Cannabidiol has potential therapeutic benefits for people with psychiatric disorders characterised by reward function impairment. There is existing evidence that cannabidiol may influence some aspects of processing. However, it unknown whether acutely affects brain underpinning anticipation and feedback. Hypotheses: We predicted would augment activity associated Methods: administered a single 600 mg oral dose matched placebo to 23 healthy participants in double-blind,...
Brivaracetam (BRV) is licensed as an adjunctive treatment for focal epilepsy. We describe our clinical experience with BRV at a large UK tertiary center.Adults initiated on between July 2015 and 2020 were followed up until they discontinued or September 2021. Data epilepsy syndrome, duration, seizure types, concomitant previous antiseizure medication (ASM) use, dosing, efficacy, side effects recorded. Efficacy was categorized temporary (minimum three months) ongoing (at last follow-up)...
Background It is well-established that what good for the heart brain. Vascular factors such as hypertension, diabetes, and high cholesterol, genetic apolipoprotein E4 allele increase risk of developing both cardiovascular disease dementia. However, mechanisms underlying heart–brain association remain unclear. Recent evidence suggests impairments in vascular phenotypes cerebrovascular reactivity (CVR) may play an important role cognitive decline. The Heart Brain Study combines...
Abstract Background The Coronavirus disease (COVID-19) pandemic has contributed to over 900,000 deaths worldwide. Hospitals responded by expanding services accommodate the forecasted rise in COVID-19-related admissions. We describe effects these changes had on management of orthopaedic trauma and patient outcomes at a district general hospital Southern England. Method Data were extrapolated retrospectively from two separate six-week periods 2019 2020 (1st April - 13th May) using electronic...
Abstract Background : The Coronavirus disease (COVID-19) pandemic has contributed to over 1,000,000 deaths worldwide. Hospitals responded by expanding services accommodate the forecasted rise in COVID-19-related admissions. We describe effects these changes had on management of orthopaedic trauma and patient outcomes at a district general hospital Southern England. Methods Data were extrapolated retrospectively from two separate six-week periods 2019 2020 (1st April - 13th May) using...