A5074009232- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Supercapacitor Materials and Fabrication
- Extraction and Separation Processes
- Advanced Battery Technologies Research
- Electron and X-Ray Spectroscopy Techniques
- Ion channel regulation and function
- Cystic Fibrosis Research Advances
- Inflammasome and immune disorders
- Graphene research and applications
- Drug Transport and Resistance Mechanisms
- Neonatal Respiratory Health Research
- Biochemical Analysis and Sensing Techniques
- Genetic Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- IL-33, ST2, and ILC Pathways
- Probiotics and Fermented Foods
- Semiconductor materials and interfaces
- Advanced biosensing and bioanalysis techniques
- Chemical and Physical Properties in Aqueous Solutions
- Machine Learning in Bioinformatics
- Natural Language Processing Techniques
- NF-κB Signaling Pathways
- Microtubule and mitosis dynamics
- Advancements in Solid Oxide Fuel Cells
University of Campania "Luigi Vanvitelli"
2024
National Research Council
2023
University of Milano-Bicocca
2016-2021
University of Oxford
2020-2021
Instituto di Biofisica
2013-2020
National Interuniversity Consortium of Materials Science and Technology
2019
Mylan (Switzerland)
2019
Istituto Giannina Gaslini
2010-2016
Centre Hospitalier Universitaire de Bordeaux
2016
Ube (Japan)
2016
NLRP12 mutations have been described in patients affected with peculiar autoinflammatory symptoms. This study was undertaken to characterize syndromes, particularly a novel missense mutation, p.D294E, affecting protein sequence crucial for ATP binding, which identified Caucasian family familial cold-induced syndrome some members.Fifty were tested mutations. A the p.D294E mutation of members clinically characterized. In vitro analysis effects on NF-κB activity performed HEK 293 cells after...
Potassium-ion batteries (KIB) are a promising complementary technology to lithium-ion because of the comparative abundance and affordability potassium. Currently, most KIB chemistry consists potassium manganese hexacyanoferrate (KMF) cathode, Prussian blue analog, graphite anode (723 W h l–1 359 kg–1 at 3.6 V). No electrolyte has yet been formulated that is concurrently stable high operating potential KMF (4.02 V vs K+/K) compatible with K+ intercalation into graphite, currently critical...
Background Neuroblastoma (NB) is a severe pediatric tumor originating from neural crest derivatives and accounting for 15% of childhood cancer mortality. The heterogeneous complex genetic etiology has been confirmed with the identification mutations in two genes, encoding receptor tyrosine kinase Anaplastic Lymphoma Kinase (ALK) transcription factor Paired-like Homeobox 2B (PHOX2B), limited proportion NB patients. Interestingly, these genes are overexpressed great majority primary samples...
Abstract Anion selective ionophores, anionophores, are small molecules capable of facilitating the transmembrane transport anions. Inspired in structure natural product prodigiosin, four novel anionophores 1a-d, including a 1,2,3-triazole group, were prepared. These compounds proved highly efficient anion exchangers model phospholipid liposomes. The changes hydrogen bond cleft modified selectivity exhibited by these compared to prodigiosin and suppressed characteristic high toxicity product....
The surface defects of graphite play a key role in its catalytic activity towards the oxygen reduction reaction.
Transition metal oxides on reduced graphene oxide (TMO@rGO) nanocomposites were successfully prepared via a very simple one-step solvothermal process, involving the simultaneous (thermal) reduction of to and deposition TMO nanoparticles over its surface. Texture morphology, microstructure, chemical surface compositions investigated scanning electron microscopy, X-ray diffraction, micro-Raman spectroscopy, photoelectron respectively. The results prove that Fe 2 O 3 @rGO, CoFe 4 CoO@rGO are...
Cystic fibrosis (CF) is a genetic lethal disease, originated from the defective function of CFTR protein, chloride and bicarbonate permeable transmembrane channel. CF mutations affect protein through variety molecular mechanisms which result in different functional defects. Current therapeutic approaches are targeted to specific groups patients that share common defect. We seek develop an innovative approach for treatment using anionophores, small molecules facilitate transport anions. have...
Background and Purpose Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease that originates from the defective function of CF transmembrane conductance regulator (CFTR) protein, cAMP‐dependent anion channel involved in fluid transport across epithelium. Because small synthetic transporters (anionophores) can replace biological mechanisms, independent mutations CFTR, such anionophores are candidates as new potential treatments for CF. Experimental Approach In order to assess...
Cystic fibrosis (CF) is a genetic disease characterized by the lack of cystic transmembrane conductance regulator (CFTR) protein expressed in epithelial cells. The resulting defective chloride and bicarbonate secretion imbalance transepithelial homeostasis lead to abnormal airway surface liquid (ASL) composition properties. reduced ASL volume impairs ciliary beating with consequent accumulation sticky mucus. This situation prevents normal mucociliary clearance, favouring survival...
Abstract In this work, the production of low cost and environment friendly anodes for sodium ion batteries is investigated. Algae are selected as bio-source non-graphitic Hard Carbon (HC) with open structure acting intercalation active material Na ions storage. Chlorella vulgaris algae were pyrolyzed at temperatures comprised between 800 1100 °C. The decomposition products have been characterized Scanning Electrode Microscope (SEM) X-Ray Diffraction (XRD) analyses their compared to one...
Mutations in the gene coding for skeletal muscle Cl(-) channel (CLCN1) lead to dominant or recessive myotonia. Here, we identified and characterized CLCN1 mutations Costa Rican patients, who had been clinically diagnosed with myotonic dystrophy type 1 but were negative DM1 mutations. c.501C>G, p.F167L c.1235A>C, p.Q412P appeared have inheritance patients atypical clinical phenotypes; c.313C>T, p.R105C was found combination an apparently family c.461A>G, p.Q154R variant associated a less...
Abstract Electrospinning is a powerful and versatile technique to produce efficient, specifically tailored high-added value anodes for lithium ion batteries. Indeed, electrospun carbon nanofibers (CNFs) provide faster intercalation kinetics, shorter diffusion paths ions/electrons transport larger number of insertion sites with respect commonly employed powder materials. With view further enhance battery performances, red phosphorous (RP) considered one the most promising materials that can...
Abstract Sodium-ion batteries (SIBs) potentially represent a more sustainable, less expensive and environmentally friendly alternative to lithium-ion batteries. The development of new low-cost, non-toxic, highly performing electrode materials is the key point for SIB technology advances. This study develops basic life cycle assessment (LCA) model evaluation production by electrospinning iron (III) oxide-based fibers be used as anode in SIBs. Indeed, it has been recently demonstrated that...
Abstract One of the most common mutations in Cystic Fibrosis (CF) patients is deletion amino acid phenylalanine at position 508. This mutation causes both protein trafficking defect and an early degradation. Over time, small molecules, called correctors, capable increasing amount mutated channel plasma membrane causing increase its transport activity have been developed. study shows that incubating vitro cells permanently transfected with correctors VX809, VX661 Corr4a, combination VX809 a...
The effect of the type dopant (titanium and manganese) reduced graphene oxide content (rGO, 30 or 50 wt %) α-Fe2O3@rGO nanocomposites on their microstructural properties electrochemical performance was investigated. Nanostructured composites were synthesized by a simple one-step solvothermal method evaluated as anode materials for sodium ion batteries. doping does not influence crystalline phase morphology iron nanoparticles, but remarkably increases stability Coulombic efficiency with...
Abstract Chronic intestinal pseudo‐obstruction (CIPO) can occur as a consequence of neuropathies including diffuse Intestinal Neuronal Dysplasia (IND), relatively rare enteric nervous system (ENS) abnormality. Although various authors reported IND associated either with malrotation or megacystis, the co‐existence these three entities in same patient has never been described before. The aim this paper is to report for first time literature series such association, focusing on one who carries...
Objective. Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant multisystemic autoinflammatory condition. Patients display different mutations of the TNF receptor superfamily 1A gene ( TNFRSF1A ), coding for a nearly ubiquitous (TNFR1). No mutation has been identified in proportion patients with TRAPS-like phenotype. Methods. We investigated mechanisms downregulating TNF-induced inflammatory response such as (1) shedding, producing secreted form...
Abstract Ilmenite, general formula FeTiO 3 , has been proposed as possible conversion anode material for lithium‐ and sodium‐ion batteries, with theoretical capacity of 530 mAhg −1 . Experimentally, the observed specific pristine ilmenite is far away from value; this reason, control morphology via alkaline hydrothermal treatment strategy to improve electrochemical performance. At same time prone react sodium potassium hydroxide, already demonstrated by studies on degradation extraction TiO 2...