A5009982772- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Poisoning and overdose treatments
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Coffee research and impacts
- Neuroscience of respiration and sleep
- Climate Change, Adaptation, Migration
- Connexins and lens biology
- Epilepsy research and treatment
- Anatomy and Medical Technology
- Adipose Tissue and Metabolism
- Restraint-Related Deaths
- Pain Mechanisms and Treatments
- Radioactive contamination and transfer
- Advanced X-ray and CT Imaging
- Autopsy Techniques and Outcomes
- Injury Epidemiology and Prevention
- Pharmacology and Obesity Treatment
- Plant-based Medicinal Research
- Advanced Glycation End Products research
- Tryptophan and brain disorders
- Ion channel regulation and function
Kagawa University
2022-2025
Okayama University
2022
Abstract Here, we investigate whether ethanol (EtOH) and nicotine (Nic) alone or in co-exposure can restore the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depletion of dopamine (DA), DA metabolites, tyrosine hydroxylase (TH) striatum hippocampus C57BL/6N mice. MPTP-treated mice were treated intraperitoneally with saline (control), EtOH (1.0–3.0 g/kg), Nic (0.5–2.0 mg/kg), a combination Nic. Brain samples collected 1 h after treatment. its metabolites...
We performed a microdialysis study to examine the effects of local perfusion COA‑Cl on extracellular levels dopamine (DA) and its metabolites in dorsal striatum mice vivo. The were perfused with Ringer's solution (control) (0.05, 0.1, or 0.5 mM) into striatum. Dialysate samples collected every 30 min then analyzed using high‑performance liquid chromatography coupled an electrochemical detector. found that (0.1 living produced significant dose‑dependent increase DA, 3‑methoxytyramine (3‑MT),...
We present a fatal case of pilsicainide poisoning. Quantitative toxicological analysis revealed that the concentrations in femoral blood and urine samples were 17.5 μg/mL 136.9 μg/mL, respectively. No morphological changes due to poisoning observed. Based on autopsy findings, results examination, investigation by authorities, we concluded cause death was
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 0.22 μg/ml, respectively. We concluded that the death was due to additive effects two barbiturates. As both pentobarbital phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity suppressed, causing...
A fatal case of drowning under the influence etizolam is presented. Quantitative toxicological analysis revealed concentrations 0.50 µg/mL and 0.068 in femoral venous blood urine, respectively. According to autopsy findings, results examinations, investigation by authorities, it concluded that cause death etizolam.