BACKGROUND/AIMS--The course of primary sclerosing cholangitis (PSC) is highly variable and unpredictable. This study describes the natural history outcome PSC. These data were used to construct a prognostic model for patients with METHODS--A total 305 Swedish PSC studied. The median follow up time was 63 (1-194) months all could be traced up. Some 79 died or had liver transplant. significance clinical, biochemical, histological findings at diagnosis evaluated using multivariate analysis....

Objective: To compare the effect of walking training on a treadmill with body weight support (BWS) and ground at an early stage rehabilitation in patients hemiparesis after stroke. Design: Randomized controlled experimental study. Setting: Multicentre design; three departments medicine. Subjects: Seventy-three consecutive first stroke admitted to clinic were randomized into treatment group control group. Interventions: The received BWS for 30 minutes, 5 days week. according Motor Relearning...

SUMMARY The impact of chronic inflammation on the expression human α-defensins 5 and 6 (HD-5, HD-6), β-defensins 1 2 (hBD-1, hBD-2) lysozyme in epithelial cells small large intestine was investigated. Intestinal specimens from 16 patients with ulcerative colitis (UC), 14 Crohn's disease (CD) 40 controls no history inflammatory bowel were studied. mRNA levels five defence molecules determined freshly isolated by real-time quantitative RT-PCR. Specific copy standards used allowing comparison...

Abstract. Objectives . To describe the evolution of nutritional and neurological complications in a Swedish population patients with familial amyloidotic polyneuropathy, to identify prognostic factors useful tests for monitoring progress disease. Design Prospective retrospective study polyneuropathy. Setting Tertiary referral centre. Subjects Twenty‐seven symptomatic onset before age 50. Main outcome measures Age at onset, duration disease death, serum albumin, body mass index (BMI), grade...

Aliment Pharmacol Ther 2010; 32: 1154–1162 Summary Background Reliable epidemiological data for portal vein thrombosis are lacking. Aims To investigate the incidence, prevalence and survival rates patients with thrombosis. Methods Retrospective multicentre study of all registered diagnosis between 1995 2004. Results A total 173 (median age 57 years, 93 men) were identified followed up a median 2.5 years (range 0–9.7). The mean age‐standardized incidence 0.7 per 100 000 year 3.7 inhabitants,...

Abstract. Objective. To determine the causes and outcome of all patients with acute liver failure (ALF) in Sweden 1994–2003 study diagnostic accuracy King's College Hospital (KCH) criteria model for end‐stage disease (MELD) score transplant‐free deaths as a positive outcome. Research design methods. Adult international normalized ratio (INR) ≥1.5 due to severe injury without encephalopathy at admission between were included. Results. A total 279 identified. The most common cause ALF...

Reduced upper extremity function is one of the most common impairments after stroke and has previously been reported in approximately 70-80% patients acute stage. Acute care for changes over last years, with more people being admitted to a unit as well use thrombolysis. The aim present study was describe baseline characteristics, pathway discharge status an unselected group first occasion who were at within 72 hours also investigate frequency impaired arm hand function. A second explore...

The aims of this study were to describe the prevalence and severity upper-limb spasticity during first year after stroke analyze sensorimotor function, pain, reduced range motion, sensibility in persons with without spasticity.This is a longitudinal design assessments at days 3 10; week 4; mos 3, 6, 12. A total 117 patients first-ever arm paresis on day consecutively included. Sixty-five percent assessed 12 mos. Upper-limb was Modified Ashworth Scale, score 1 or greater considered spastic....

<h3>BACKGROUND</h3> Pulmonary function in patients with adolescent idiopathic scoliosis many years after posterior spinal surgery or brace treatment has not been documented. <h3>METHODS</h3> A consecutive group of treated by fusion a at least 20 previously was investigated. 90% attended clinical follow up. Lung volumes were determined before 251 patients, 1.4 141 and 25 start 110 patients. Vital capacity (VC) calculated as percentage predicted according to height age the results corrected...

SUMMARY Objectives : To see if budesonide, a second generation glucocorticosteroid with high topical effect and first‐pass metabolism of 90% in the healthy liver, can induce biochemical remission autoimmune chronic active hepatitis before being metabolized, further to study on endogenous plasma cortisol levels corticosteroid‐related side effects. Patients design Thirteen patients (11 females) were treated openly for up 9 months by oral budesonide capsules. The initial dose was 6–8 mg (mean...

To study sampling variability of percutaneous liver biopsy in primary sclerosing cholangitis (PSC).One hundred and twelve specimens (that is, 56 pairs) from 44 patients with PSC, confirmed by cholangiography, were evaluated blindly. Six different features, qualitative grading four other features staging according to Ludwig assessed.Quantitative was confined mainly just one grade or stage, although 11% (six 56) the specimen pairs differed more than stage (7% (one 15) > 2 cm length)....

SUMMARY mRNA expression of two recently described human β-defensins (hBD-3 and hBD-4) in epithelial cells normal small large intestine the impact chronic intestinal inflammation on their levels was investigated. Intestinal specimens from patients with ulcerative colitis (UC), Crohn's disease (CD) controls no history inflammatory bowel were studied. hBD-3 hBD-4 mRNAs determined freshly isolated by real-time quantitative reverse transcription–polymerase chain reaction (QRT-PCR) situ...

The aim of this study was to evaluate whether budesonide enema (2 mg/100 ml) had a significantly better effect than placebo in the treatment distal ulcerative colitis or proctitis. trial controlled, randomized, double-blind design and included 41 treated patients. time 4 weeks, with revisits after 2 weeks. If no improvement seen, patient could be switched over open-label therapy enema. Sigmoidoscopy, histology, blood chemistry, diary cards were used for estimating treatment. results showed...

To measure walking speed and energy cost in patients with prior stroke without a carbon composite ankle foot orthosis.Within-group comparisons of 2 conditions.Convenience sample 10 hemiparetic at least 6 months earlier (average age 52 years) habituated to orthosis.Subjects walked on treadmill self-selected both orthosis for 5 minutes each occasion. Energy expenditure was measured by breath-by-breath analysis electrocardiography. Main outcome measures were speed, oxygen consumption, heart...

A frequently used clinical test to assess mobility after stroke is the Timed Up & Go. Knowledge regarding whether or not Go able detect change over time in patients with stroke, improvements exist first three months and longitudinal depend on patients' age, limited unclear. The objectives were investigate distribution-based responsiveness of (TUG) during a event measure TUG year establish recovery differs between different age groups. Ninety-one first-ever assessed using at 1st week 3, 6 12...

The occurrence of chronic diarrhoea was evaluated in 173 consecutive patients previously treated with radiation for gynaecological cancer. A survey gastrointestinal symptoms showed a high frequency diarrhoea; 13% the had 21 or more bowel movements week and 3% 28 more. Significantly who cholecystectomy were group (chi 2 = 6.26; p less than 0.02). Twenty intermittent subject to extended investigation. Bile acid malabsorption by 75Selenahomocholic acid-taurine test (SeHCAT). found 13 (65%) 20...

To identify predictors and the optimal time point for early prediction of presence severity spasticity in upper limb 12 months poststroke.In total, 117 patients Gothenburg area who had experienced a stroke first with documented arm paresis day 3 poststroke were consecutively included. Assessments made at admission 10 days, 4 weeks, poststroke. Upper elbow flexion/extension wrist was assessed modified Ashworth Scale (MAS). Any regarded as MAS ≥1, severe ≥2 any muscles. Sensorimotor function,...

Purpose: To determine the long-term outcome after fusion for adolescent idiopathic scoliosis in terms of degenerative disc findings diagnosed using MR imaging and to elucidate clinical consequences. Material Methods: Thirty-two patients with scoliosis, who had undergone spinal Harrington rods lower lumbar spine one or two unfused discs below fusion, were re-examined 25 years fusion. The re-examinations included validated questionnaires, examination, full standing frontal lateral radiographs...

Background: Gastrointestinal complaints may be the initial symptom in myotonic dystrophy (MD). However, frequency of gastrointestinal symptoms has never been prospectively evaluated. Methods: Forty patients with MD were interviewed regard to their GI a standardized questionnaire. A group healthy subjects matched for age and sex served as controls. Results: The most prevalent abdominal pain (55%), dysphagia (45%), emesis (35%), chronic or episodic diarrhoea (33%), coughing while eating anal...

Background Physical activity has been established as being highly beneficial for health after stroke. There are considerable global efforts to find rehabilitation programs that encourage increased physical persons with However, many stroke or acquired brain injury do not reach recommended levels of and knowledge about why is needed. We aimed explore views experiences walking among injury. Method A qualitative study was conducted, (n = 8) 2) from a unit at Sahlgrenska University Hospital in...

To examine the intra- and inter-rater reliability of Action Research Arm Test (ARAT) at item level after stroke.An intra-rater study.Thirty-five participants (median age 62 years, median time post-stroke 22 months) with impaired upper extremity function stroke were included in study.Two physiotherapists simultaneously, but independently, assessed participants' performance all 19 items ARAT twice 1 day. A rank-based statistical method for paired ordinal data, including calculation percentage...