A5067363341- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- Toxic Organic Pollutants Impact
- Computational Drug Discovery Methods
- Carcinogens and Genotoxicity Assessment
- Receptor Mechanisms and Signaling
- Bioactive Compounds and Antitumor Agents
Research Center for Eco-Environmental Sciences
2019-2024
Chinese Academy of Sciences
2019-2024
University of Chinese Academy of Sciences
2019-2021
The extensive applications of parabens in foods, drugs, and cosmetics cause inevitable exposure to humans. Revealing the developmental toxicity is utmost importance regarding their safety evaluation. In this study, effects four commonly used parabens, including methyl paraben (20 ∼ 200 μM), ethyl 100 propyl (5 20 butyl (BuP, 2 10 were investigated on early development zebrafish embryos larvae. underlying mechanisms explored from aspect disturbance thyroid endocrine system using vivo, vitro,...
Numerous chemicals have been reported to exert estrogen-like endocrine disrupting effects via a receptor binding mechanism that directly interacts with the ligand domain of estrogen α (ERα). However, not only their affinities ERα but also interference in specific cell and tissue functions are clearly different. In this regard, significant regulation differences among three representative estrogenic (diethylstilbestrol (DES), bisphenol A (BPA), diarylpropionitrile (DPN)), well-known agonists...
Fluorene-9-bisphenol (BHPF) is an emerging contaminant. Presently, there no report on its interaction with G protein-coupled estrogen receptor 1 (GPER). By using integrated toxicity research scenario that combined theoretical study experimental methods, BHPF was found to inhibit the GPER-mediated effect via direct binding. Molecular dynamics simulations Trp2726.48 and Glu2756.51 be key amino acids of binding GPER. Moreover, calculation indicated a suspected GPER inhibitor, which neither can...