A5102950882- Zebrafish Biomedical Research Applications
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Prenatal Substance Exposure Effects
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Neurogenesis and neuroplasticity mechanisms
- Hormonal and reproductive studies
- Folate and B Vitamins Research
- Ion channel regulation and function
- Glycosylation and Glycoproteins Research
- Cardiovascular Effects of Exercise
- Signaling Pathways in Disease
- Cardiac electrophysiology and arrhythmias
- Muscle metabolism and nutrition
- Bone Metabolism and Diseases
- Musculoskeletal pain and rehabilitation
- Bone health and treatments
- Physiological and biochemical adaptations
University of Calcutta
2023-2025
Hospital for Sick Children
2018-2024
University of Toronto
2013-2023
SickKids Foundation
2019-2022
Indian Statistical Institute
2021
Canada Research Chairs
2007-2020
Columbia University
2016
Meharry Medical College
2001-2005
Yale University
1991-1994
Indian Institute of Chemical Biology
1984-1987
Deletion of the c-src gene in transgenic mice by homologous recombination leads to osteopetrosis, a skeletal defect characterized markedly deficient bone resorption (Soriano, P., C. Montgomery, R. Geske, and A. Bradley. 1991. Cell. 64:693-702), demonstrating critical functional role pp60c-src osteoclast activity. Since decreased could result from either within or other cells present its environment, indirectly affecting functions, we determined which cell(s) expressed high levels Measuring...
The zebrafish has been in the forefront of developmental genetics for decades and also gaining attention neurobehavioral genetics. It proposed to model alcohol-induced changes human brain function behavior. Here, adult populations, AB SF (short-fin wild type), were exposed chronic treatment (several days 0.00% or 0.50% alcohol v/v) a subsequent acute (1 h 0.00%, 0.25%, 1.00% alcohol). Behavioral responses computer-animated images, including shoal predator, quantified using videotracking....
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by myocardial replacement and life-threatening arrhythmias. Desmosomal gene mutations are sometimes identified, but clinical genetic diagnosis remains challenging. skin disorders can be caused desmosomal or autoantibodies. We sought to determine if anti-desmosome antibodies present in subjects with ARVC.
Unpredictable chronic mild stress (UCMS) and developmental social isolation are often utilized in laboratory animals to mimic unpredictable life stressors early adversity that may contribute the development of major depressive disorder humans. Zebrafish (Danio rerio) have been used examine effects both UCMS. However, anxiety-like behavioral responses, behavior, neurochemical changes induced by not well characterized. Furthermore, possible interaction between UCMS remains unexplored. In this...
Analysis of proton (H+) transport by inside-out vesicles derived from highly purified chicken osteoclast (OC) membranes has revealed the presence a newly discovered type vacuolar H+ ATPase (V-ATPase). Unlike any other cell or organelle, in OC-derived is sensitive to V-ATPase inhibitors (N-ethylmaleimide and Bafilomycin A1) vanadate (IC50, 100 microM), an inhibitor previously found affect only P-type ATPases. The OC contains several V-like subunits (115, 39, 16 kDa) but A B catalytic domain...
Calcitonin is a calcium regulating peptide hormone with binding sites in kidney and bone as well the central nervous system. The mechanisms of signal transduction by calcitonin receptors were studied pig cell line where was found to regulate sodium pumps. activated cyclic adenosine monophosphate (cAMP) or protein kinase C (PKC) pathways. two pathways required guanosine triphosphate (GTP)-binding proteins (G proteins) (the choleratoxin sensitive Gs pertussis toxin Gi, respectively) led...
The zebrafish is a social vertebrate and an excellent translational model for variety of human disorders. Abnormal behavior hallmark several brain Social behavioral problems can arise as result adverse early environment. Little known about the effects isolation in adult zebrafish. We compared that were isolated either short (7 days) or long duration (180 to socially housed zebrafish, testing their across ontogenesis (ages 10, 30, 60, 90, 120, 180 days), shoal cohesion whole-brain monoamines...
Social isolation can be used to study behavioral, neural, and hormonal mechanisms that regulate interactions in social animals. Although effects have been reported mammals various fish species, systematic studies with isolated zebrafish are rare. Here, the authors examined behavior (social nonsocial), physiological stress (whole-body cortisol levels), neurochemicals (serotonin, dopamine, their metabolites), following acute chronic adult zebrafish. To observe how respond behaviorally stimuli,...
Recent studies have started to examine the neurochemical and hormonal basis of behavior in zebrafish by examining biological correlates postmortem. However, it is unknown whether stress involved with experimental handling prior euthanizing animals will an impact on subsequent measures. In current study, we expose a short net stressor (30 s) levels monoamine neurotransmitters (dopamine, serotonin, their metabolites) whole-body cortisol at different intervals poststressor (0, 1, 5, 10, 15...
Brugada syndrome (BrS) is characterized by a unique electrocardiogram (ECG) pattern and life-threatening arrhythmias. However, the Type 1 ECG often transient, genetic cause only identified in <25% of patients. We sought to identify an additional biomarker for this rare condition. As myocardial inflammation may be present BrS, we evaluated whether autoantibodies can detected these