A5063137089- Psychedelics and Drug Studies
- Chemical synthesis and alkaloids
- Memory and Neural Mechanisms
- Anesthesia and Sedative Agents
- Sleep and Wakefulness Research
- Anesthesia and Neurotoxicity Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine regulation and behavior
- Chemical Reactions and Isotopes
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Biochemical Analysis and Sensing Techniques
- Natural Compound Pharmacology Studies
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
University of Michigan
2021-2024
University of Oregon
2024
Multidisciplinary Association for Psychedelic Studies
2023
Laboratoire d’immunologie intégrative du cancer
2022
Interest in and availability of psychedelics for therapeutic purposes has increased recent decades. In a large, anonymous, online survey, we investigated patterns communication with healthcare providers awareness utilization substance testing kits or services among people using naturalistically. The sample population included attendees psychedelic activism event users social media forums. Among 1,435 participants, 72.5% never discussed use their primary care provider (PCP). Only 4.4%...
There is substantial public interest in psychedelics as potential treatments for psychiatric conditions. However, most are criminalized under federal law the USA, so it unclear whether use occurs with clinical support. Our objective was to assess naturalistic psychedelic support, interactions between those using and healthcare providers (psychiatrist, therapist, or primary physicians), characteristics.We conducted an online, anonymous, confidential, cross-sectional survey of adults reporting...
BACKGROUND: Cholinergic stimulation of prefrontal cortex (PFC) can reverse anesthesia. Conversely, inactivation PFC delay emergence from receives cholinergic projections basal forebrain, which contains wake-promoting neurons. However, the role forebrain neurons in arousal anesthetized state requires refinement, and it is currently unknown whether arousal-promoting effect mediated through PFC. To address these gaps knowledge, we implemented a novel approach to use chemogenetic tested...
Serotonergic psychedelics enhance neurophysiological complexity and the repertoire of brain states, whereas general anesthetics produce opposite effects. are also known to increase wakefulness reduce sleep time in rodents. Therefore, we hypothesized that 2,5-dimethoxy-4-iodopamphetamine (DOI), a serotonergic psychedelic, will reverse anesthesia restore conditions associated with normal wakefulness. We demonstrate intravenous administration DOI rats under induced despite ongoing delivery...
Studies aimed at investigating brain regions involved in arousal state control have been traditionally limited to subcortical structures. In the current study, we tested hypothesis that inactivation of prefrontal cortex, but not two subregions within parietal cortex-somatosensory barrel field and medial/lateral association cortex-would suppress arousal, as measured by an increase anesthetic sensitivity. Male female Sprague Dawley rats were surgically prepared for recording...
BackgroundSleep disruption is a common occurrence during medical care and detrimental to patient recovery. Long-term sedation in the critical setting modifiable factor that affects sleep, but impact of different sedative–hypnotics on sleep homeostasis not clear.MethodsWe conducted systematic comparison effects prolonged (8 h) with i.v. inhalational agents homeostasis. Adult Sprague–Dawley rats (n=10) received dexmedetomidine or midazolam separate days. Another group (n=9) propofol...
BACKGROUND: Neurophysiologic complexity has been shown to decrease during states characterized by a depressed level of consciousness, such as sleep or anesthesia. Conversely, neurophysiologic is increased exposure serotonergic psychedelics subanesthetic doses dissociative anesthetics. However, the neurochemical substrates underlying changes in are poorly characterized. Cortical acetylcholine appears relate cortical activation and but relationship between not formally studied. We addressed...
Identifying gaps and strengths in psychedelic-related knowledge is key to developing effective, evidence-based education inform appropriate use of harm reduction practices for psychedelics the naturalistic landscape. The current study piloted an assessment instrument with questions on legal status, therapeutic potential, side effects among people reporting psychedelic use. We recruited participants (
Background We recently showed that cholinergic stimulation of prefrontal cortex (PFC), via local carbachol delivery, increased acetylcholine (ACh) levels and restored wakefulness in sevoflurane-anesthetized rats.[1] PFC receives projections from basal forebrain (BF), activation BF neurons has been shown to promote behavioral arousal.[2] Increase ACh during carbachol-induced wake state reflects activation, but it is not known if acts arousal. The objective the current study test hypothesis...