A5082681848- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Iron Metabolism and Disorders
- RNA modifications and cancer
- Psychedelics and Drug Studies
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Anodic Oxide Films and Nanostructures
- Advanced biosensing and bioanalysis techniques
- Hemoglobinopathies and Related Disorders
- Cancer, Hypoxia, and Metabolism
- Molecular Communication and Nanonetworks
- Emergency and Acute Care Studies
- PARP inhibition in cancer therapy
- Pain Management and Placebo Effect
- Mental Health Research Topics
- MicroRNA in disease regulation
- Sports injuries and prevention
- Transcranial Magnetic Stimulation Studies
- Ferroptosis and cancer prognosis
- Muscle activation and electromyography studies
- Perfectionism, Procrastination, Anxiety Studies
- Erythropoietin and Anemia Treatment
- Lung Cancer Treatments and Mutations
- Chemical synthesis and alkaloids
University of Michigan
2023-2025
Michigan Medicine
2023
Johns Hopkins University
2018-2021
Johns Hopkins Medicine
2021
Pennsylvania State University
2014-2017
Penn State Milton S. Hershey Medical Center
2011-2017
Geisinger Medical Center
2015
Michigan State University
2008
The spread of cancer into the central nervous system is a serious problem leading to neurological symptoms and rapid mortality. current tools available for detecting cerebrospinal fluid (CSF) are cytology, neurologic examination, neuroimaging. All three these methods can be applied in concert reach diagnosis, but they all suffer from lack sensitivity, delays treatment many cases. An overview research field CSF detection reveals variety promising technologies that used answer questions about...
There is substantial public interest in psychedelics as potential treatments for psychiatric conditions. However, most are criminalized under federal law the USA, so it unclear whether use occurs with clinical support. Our objective was to assess naturalistic psychedelic support, interactions between those using and healthcare providers (psychiatrist, therapist, or primary physicians), characteristics.We conducted an online, anonymous, confidential, cross-sectional survey of adults reporting...
Fibromyalgia (FM) is the prototypical nociplastic pain condition, characterized by widespread and issues with cognition, mood, sleep. Currently, there are limited treatment options available that effectively treat FM symptoms. Psilocybin-assisted therapy (PAT) an emerging combined drug-therapy intervention, but no studies to-date have investigated PAT for FM. Here, we report findings from open-label, pilot clinical trial of (N = 5). In conjunction psychotherapy (two preparatory, four...
Iron is a tightly regulated micronutrient with no physiologic means of elimination and necessary for cell division in normal tissue. Recent evidence suggests that dysregulation iron regulatory proteins may play role cancer pathophysiology. We use public data from The Cancer Genome Atlas (TCGA) to study the association between survival expression levels 61 genes coding patients World Health Organization Grade II-III gliomas. Using feature selection algorithm we identified novel, optimized...
Abstract Electroconvulsive therapy (ECT) is an effective and rapid treatment for severe depression, however predictors of therapeutic outcomes remain insufficiently understood. Ictal duration postictal suppression are two that may be correlated with patient response, yet variables which influence these have not been thoroughly explored. We collected ECT stimulus metrics, EEG parameters, demographics, primary diagnosis, anesthesia type retrospective ECTs. Univariate multivariate mixed-effects...
Background:We investigated the effects of frequently polymorphic high iron gene (HFE), on tumor growth in a novel mouse model.We hypothesized that host mutations HFE protein modify progression.Methods: C57BL/6 mice possessing either H67D/H67D or WT/WT genotype, aged 18 months, were injected subcutaneously with 4x10 6 cells B16F10 melanoma cell line.After 2 weeks, sacrificed and tumors plasma collected.Animal methods approved by our IACUC, (04-166).Tumors analyzed RT-PCR.In parallel, bone...
Fibromyalgia (FM) is the prototypical nociplastic pain condition, characterized by widespread and issues with cognition, mood, sleep. Currently, there are limited treatment options available that effectively treat FM symptoms. Psilocybin-assisted therapy (PAT) an emerging combined drug-therapy intervention, but no studies to-date have investigated PAT for FM. Here, we report findings from open-label, proof-of-concept trial of (N=5; NCT05128162). In conjunction psychotherapy (two preparatory,...
Abstract We evaluated general patient features related to depression and frequency of Emergency Department (ED) use in a large integrated health care system. Electronic Health Records 287,281 adults from population were studied retrospectively over 10-year period. Patients with history more likely be seen the ED at higher than those without. Frequent users have or psychiatric medication orders infrequent users. visits by patients frequent highly correlated complaints discharge diagnoses...
Abstract Introduction: Studies suggest that iron metabolism is associated with tumor progression, but a mechanism and the relative importance of different handling proteins still remain to be elucidated. We investigated effects frequently polymorphic high gene (HFE), on growth. This study significant because ability HFE mutant protein alter our previous studies have shown presence this mutation altered cancer phenotype in cells. Hypothesis: Mutations modify progression metastatic potential....
TUMOR MICROENVIRONMENT TMIC-01. TARGETED QUANTUM DOTS TO IDENTIFY GLIOMA INITIATING CELLS AND EXOSOMES Achutha Madhankumar, Oliver Mrowczynski, Suhag Patel, Elias Rizk, Cody Weston, Michael Glantz, Lichong Xu, Christopher Siedlecki, and James Connor; Pennsylvania State University College of Medicine, Hershey, PA, USA GBM certain brain metastatic cancers possess invasiveness high infiltrating potential making them harder to detect at the earlier stage disease progression. Identification...
BACKGROUND: Iron is a tightly regulated micronutrient that necessary for cell division in normal tissue. Previous studies have established signature of iron regulatory genes can predict survival breast tumors. Recent evidence suggests dysregulation proteins may play role brain cancer pathophysiology. METHODS: We use public data from The Cancer Genome Atlas (TCGA) to study the association between and expression levels 61 coding patients with low grade gliomas (LGG). Specifically, we utilized...
Abstract Fire service members are a population with high prevalence of post-traumatic stress disorder (PTSD) compared to the general population. Moreover, they underrepresented in literature respect traumatic and corresponding interventions. As such, there is need improve treatment PTSD its resultant symptoms specifically fire members. This pilot study aimed evaluate efficacy multimodal intervention for US PTSD. It (i) assess effect 4-week on self-report physiologic symptoms, (ii) correlate...
Following high-intensity plantar flexion exercise, phosphocreatine (PCr) recovers in a biphasic pattern with brief initial fast phase some subjects (accompanying abstract). A possible explanation for this response is heterogeneity of oxidative capacities among fiber types. It has been well established that the soleus muscle contains higher percentage Type I fibers than gastrocnemius humans. However, whether capacity different between these muscles unclear. PURPOSE: To compare time constant...