A5004656604- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Nasal Surgery and Airway Studies
- Meningioma and schwannoma management
- Oral and Maxillofacial Pathology
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Cystic Fibrosis Research Advances
- Olfactory and Sensory Function Studies
- Bone Tumor Diagnosis and Treatments
- Pituitary Gland Disorders and Treatments
- Craniofacial Disorders and Treatments
- Ear and Head Tumors
- Obstructive Sleep Apnea Research
- Occupational health in dentistry
- Ear Surgery and Otitis Media
- Pediatric health and respiratory diseases
- Neuroendocrine Tumor Research Advances
- Cerebrospinal fluid and hydrocephalus
- Periodontal Regeneration and Treatments
- Musculoskeletal pain and rehabilitation
- Vascular Anomalies and Treatments
- Ophthalmology and Eye Disorders
Royal Prince Alfred Hospital
2016-2025
UNSW Sydney
2011-2025
Macquarie University
2017-2024
The University of Sydney
2018-2024
King Saud University
2024
Sabin Vaccine Institute
2024
Concord Repatriation General Hospital
2023
St Vincent's Clinic
2020-2022
Sydney Adventist Hospital
2020
Institute of Environmental Science and Research
2020
ABSTRACT Background Type 2 inflammation dominates eosinophilic chronic rhinosinusitis (eCRS) and adult onset asthma. IL‐4, ‐5, ‐13 are prominent disease mediators. Disease control can be achieved with biologic therapies. However, despite some patients entering remission, others experience poor control. Aim We aimed to describe eCRS treated anti‐IL‐5R antibody (benralizumab) assess characteristics between responders those requiring class switching anti‐IL‐4/13R (dupilumab). Method A...
Objectives Due to the complexity and variety of frontal recess sinus anatomy, traditional Draf 2a surgery is challenging. The thickness nasofrontal beak anterior–posterior dimensions contribute this complexity. Carolyn's window technique eliminates limitation depth facilitate a sinusotomy. approach 0° endoscope provides an excellent view recess. We describe perioperative outcomes. Methods Consecutive adult patients in whom was applied for dissection as part endoscopic management both...
Abstract Background Eosinophilic chronic rhinosinusitis is an often treatment‐resistant inflammatory disease mediated by type‐2 cytokines, including interleukin (IL)‐5. Mepolizumab, a monoclonal antibody drug targeting IL‐5, has demonstrated efficacy and safety in airway disease, but there negligible evidence on direct tissue response. The study's aim was to determine the local effect of mepolizumab biomarkers sinonasal eosinophilic patients. Methods Adult patients with received 100mg...
Objectives The purpose of this study is to demonstrate the potential contribution positron emission tomography (PET)/computed (CT) help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC). Methods Following approval by institutional review board at Wexner Medical Center Ohio State University, Columbus, Ohio, a pilot with retrospective patients biopsy‐proven diagnosis ONB s and SNUC was conducted. Staging PET/CT scans were reviewed document maximum...
Objectives The pedicled nasoseptal flap (NSF) has dramatically reduced postoperative cerebrospinal fluid leakage following endoscopic endonasal approach (EEA) surgery. Although rare, its arterial supply may be damaged during harvest or preoperatively for numerous reasons. Early recognition permits harvesting a contralateral before sacrificing pedicle as part of the surgical exposure use an alternative flap. Design Technical feasibility study and case series. Setting Tertiary care...
Central compartment atopic disease (CCAD) and eosinophilic chronic rhinosinusitis (eCRS) are two clinical phenotypes of primary diffuse type 2 (CRS) defined in the European Position Paper on Rhinosinusitis 2020 classification. Currently, distinction between these subtypes relies phenotypic features alone.This study aimed to investigate whether eosinophil activation differed CCAD eCRS.A cross-sectional was conducted adult patients presenting with eCRS who had undergone functional endoscopic...
Middle meatal antrostomy (MMA) is the traditional intervention for chronic maxillary sinusitis but often fails to correct a nonfunctioning sinus that has lost its capability mucociliary clearance. Endoscopic-modified medial maxillectomy (EMMM) can reshape and avoid "sumping" effect, preventing secondary bacterial colonization, encouraging dependent drainage, promoting effective nasal irrigation.We describe modification of EMMM surgical technique in patients with recalcitrant perioperative...
Our objective was to review the imaging features of pseudoaneurysms hand in 25 patients. The patients presented with a mass, peripheral paresthesia, or ischemia. Pseudoaneurysm is rare and often clinically unsuspected diagnosis. Correct diagnosis important because there are risks for distal embolic disease ischemia gangrene fingers, ulnar digital nerve dysfunction, rupture, bone erosion joint destruction. Scant reports appear world literature, this report first review, our knowledge,...
Eosinophilic chronic rhinosinusitis (eCRS), contemporarily classified as diffuse type 2 dominant (CRS), is characterized by eosinophil-dominant mucosal inflammation. Contemporary management of eCRS an inflammatory airway condition multimodal with corticosteroid irrigations after the surgical creation a neosinus cavity.To assess long-term treatment outcomes in patients primary CRS or receiving treatment.A prospective cohort study seen tertiary rhinology practice recruited from May 2010 to...
Abstract Background Biologic therapy targeting type 2 chronic rhinosinusitis with nasal polyps (CRSwNP) has greatly improved disease control but nonresponders exist in a proportion of patients phase 3 trials and clinical practice. This study explores the serum histologic changes biologic treated CRSwNP that predict control. Methods A cross‐sectional was performed on biologics for their asthma, who underwent endoscopic sinus surgery while therapy. At 6‐month postoperative assessment, poorly...
Objective Advancements in endoscopic endonasal approaches have increased the extent and complexity of skull base resections, turn demanding development novel techniques for defect reconstruction. The objective this pilot study was to investigate effect leukocyte-platelet-rich fibrin (L-PRF) on postoperative healing after surgery. Methods Between January May 2015, 47 patients underwent resection sellar, parasellar, suprasellar lesions with application L-PRF membranes during reconstruction at...
<b>Objectives</b> Sinonasal cancers with neuroendocrine features share similar clinical, radiological, and histopathological features; however, these tumors often exhibit varying degrees of aggressive behavior presenting significant treatment challenges. The objective this study was to report our experience rare malignancies present a review current literature. <b>Methods</b> Following institutional board approval, the records all patients biopsy-proven sinonasal over 5-year period were...